Summary
Temporally-limited internal irradiation after incorporation of short-lived bone-seeking radionuclides is a useful experimental tool for the investigation of extrinsic and intrinsic factors which modify the dose dependence of bone tumor risk. Here we describe some of the results obtained in experiments with female mice (mainly NMRI). The future aim of such experiments should be the prediction of risk of late effects using early molecular-biological changes. Molecular-biological descriptions in our model are at present very limited.
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Supported by the Commission of the European Communitis contracts no. BI-6-0080-D(B), BI-7-0002-C(MB)
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Luz, A., Muller, W.A., Linzner, U. et al. Bone tumor induction after incorporation of short-lived radionuclides. Radiat Environ Biophys 30, 225–227 (1991). https://doi.org/10.1007/BF01226625
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DOI: https://doi.org/10.1007/BF01226625