Abstract
From April 1990 to December 1993, 140 patients were recruited to a randomized study to evaluate transcatheter hepatic arterial chemoembolization (TACE) as an adjuvant therapy for primary liver carcinoma after hepatectomy. This study investigated the principle, techniques and results of TACE. The results showed that the intrahepatic recurrence rate was 48.9% in the patients who underwent radical resection only, but only 21.3% in the patients who also underwent TACE 3–4 weeks after hepatectomy (P<0.01). The 1-, 2-, 3-, and 4-year survival rates were 72.3%, 52.7%, 35.1%, and 35.1% respectively for the patients who underwent radical resection only, and were 97.9%, 85.5%, 69.5%, and 56.9% for the patients who also underwent TACE 3–4 weeks after radical resectionP<0.001). The 1-, 2-, 3-, and 4-year survival rates were 38.9%, 0%, 0%, and 0% for the patients who underwent palliative resection only, and were 68.3%, 32.3%, 21.5%, and 21.5% respectively for the patients undergoing TACE 3–4 weeks after palliative hepatectomyP<0.001).
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Abbreviations
- TACE :
-
transcatheter hepatic arterial chemoembolization
- PLC :
-
primary liver carcinoma
References
Kojiro M, Nakashima T (1987) Pathology of hepatocellular carcinoma. In: Okuda K (ed) Neoplasms of the liver. Springer, Tokyo Berlin Heidelberg New York, pp 353–104
Li GH, Li JQ (1989) Subclinical primary liver carcinoma. J Surg Oncol 42: 181–183
Nagasue N, Galizia G, Kohno H, et al (1989) Adverse effects of preoperative hepatic artery chemoembolization for resectable hepatocellular carcinoma: a restrospective comparison of 138 liver resections. Surgery 106: 81–86
Tang ZY (1985) Subclinical hepatocellular carcinoma historical aspects and general consideration. In: Tang ZY (ed) Subclinical hepatocellular carcinoma. Springer, Berlin Heidelberg New York Tokyo, pp 1–11
Wu MC, Chen H, Zhang XH (1984) Hepatic resection: a 24-year experience (in Chinese). Acta Acad Med Wuhan 6: 379–383
Yamanaka N, Okmoto, Toyosaka A, et al (1990) Prognostic factors after hepatectomy for hepatocellular carcinomas. A univariate and multivariate analysis. Cancer 65: 1104–1110
Yuki K, Hirohashi S, Sakamoto M, et al (1990) Growth and spread of hepatocellular carcinoma. Cancer 66:2174–2179
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Li, Jq., Zhang, Yq., Zhang, Wz. et al. Randomized study of chemoembolization as an adjuvant therapy for primary liver carcinoma after hepatectomy. J Cancer Res Clin Oncol 121, 364–366 (1995). https://doi.org/10.1007/BF01225689
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DOI: https://doi.org/10.1007/BF01225689