Abstract
Retinoids, including all-trans-retinoic acid, its isomers, and fifty synthetic retinoids (retinobenzoic acids), were tested for differentiation-inducing activity on human leukemia cell lines HL-60 and NB4. A good linear correlation, with anr value of 0.91, between the ED50 values for the differentiation-inducing activity towards HL-60 cells and that towards NB4 cells was found.
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Abbreviations
- APL :
-
acute promelocytic leukemia
- all-trans-RA :
-
all-trans-retinoic acid
References
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Hashimoto, Y., Kagechika, H., Kawachi, E. et al. Correlation of differentiation-inducing activity of retinoids on human leukemia cell lines HL-60 and NB4. J Cancer Res Clin Oncol 121, 696–698 (1995). https://doi.org/10.1007/BF01218530
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DOI: https://doi.org/10.1007/BF01218530