Abstract
A case of effective chemotherapy in postirradiation sarcoma is reported. A 30-year-old woman underwent a subtotal resection of a benign mixed meningioma followed by a course of radiotherapy. Five years later she developed a skull tumor which was resected. Histological study showed sarcomatous change corresponding most likely to a postirradiation osteosarcoma. Adjuvant chemotherapy (methotrexate, carboplatin, and VP16) was given. A progression occurred 8 months later and the patient was treated unsuccessfully with tamoxifen, LHRH, and later with high dose methotrexate and carboplatin. Six months later a lung metastasis was discovered and she received four cycles of IVP (ifosfamide, vepeside, cisplatin) alternating with IVA (ifosfamide, vepeside, adriamycin). Within 4 months the primary and lung tumours had decreased substantially without evidence of progression at follow-up 5 months later. We conclude that IVP/IVA regimen is a potentially useful therapy when an osteosarcoma of the skull is in progression.
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Barbaro NM, Gutin PH, Wilson CBet al.: Radiation therapy in the treatment of partially resected meningiomas. Neurosurgery 20: 525–528, 1987
Russel DS, Rubinstein LJ: Pathology of tumours of the nervous system, ed. 4. Baltimore: Williams & Wilkins. pp 471 and pp 507–508, 1989
Robinson E, Neugut AI, Wylie P: Clinical aspects of postirradiation sarcomas. J Natl Cancer Inst 80: 233–240, 1988
Wiklund TA, Blomqvist CP, RÄty Jet al.: Postirradiation sarcoma. Cancer 68: 524–531, 1990
Shinoda J, Kimura T, Funakoshi H, Iwata K, Tange C, Kasai C, Miyata Y: Primary osteosarcoma of the skull. A case report and review of the literature. J Neuro-Oncol 17: 81–88, 1993
Henson RA, Urich H: Cancer and the Nervous System (eds), Blackwell Scientific Publications, Oxford, 1982
Soloway HB: Radiation-induced neoplasms following curative therapy for retinoblastoma. Cancer 19: 1984–1988, 1966
Waltz TA, Brownell B: Sarcomas: a possible late result of effective radiation therapy for pituitary adenoma. Report of two cases. J Neurosurg 24: 901–907, 1966
Sparagana M, Eells RW, Stefani S: Osteogenic sarcoma of the skull: a rare sequela of pituitary irradiation. Cancer 29: 1376–1379, 1972
Zülch KJ: Histological typing of tumours of the central nervous system, p. 21. World health organisation, Geneva, 1979
Sundaresan N, Huvos AG, Rosen G, Galicich JH: Combined-modality treatment of osteogenic sarcoma of the skull. J Neurosurg 63: 562–567, 1985
Brade WP, Nagel GA, Seeber S: Ifosfamide in Tumour Therapy (eds). S. Karger, New York, 1987
Budd GT, Metch B, Weiss SAWet al.: Phase II trial of ifosfamide and cisplatin in the treatement of metastatic sarcomas: a Southwest Oncology Group study. Cancer Chemother Pharmacol 31 (Suppl 2): S 213-S216, 1993
Issels RD, Bosse D, Abdel-Rahman Set al.: Preoperative systemic etoposide/ifosfamide/doxorubicin chemotherapy combined with regional hyperthermia in high-risk sarcoma: a pilot study. Cancer Chemother Pharmacol 31 (Suppl 2): S233-S237, 1993
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Carpentier, A.F., Chantelard, JV., Henin, D. et al. Osteosarcoma following radiation treatment for meningioma: Report of a case and effective treatment with chemotherapy. J Neuro-Oncol 21, 249–253 (1994). https://doi.org/10.1007/BF01063774
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DOI: https://doi.org/10.1007/BF01063774