Respiratory frequency and the oxygen cost of exercise

Summary

Although many studies indicate that the spontaneous breathing frequency minimizes breathing work, the consequences of this for exercise energetics have never been investigated. To see if the spontaneous exercise breathing frequency minimizes oxygen uptake, we compared$\dot V_{{\text{O}}_{\text{2}} }$ during treadmill walking (2/3$\dot V_{{\text{O}}_{\text{2}} }$ max) at several alternative frequencies. The alternative frequencies ranged from the lowest sustainable to a frequency twice the spontaneous value. All eight subjects adjusted tidal volume to comfort. Exercise oxygen uptake was constant, independent of breathing frequency. At the same time, minute ventilation rose to be 65% greater at the highest frequency than at the lowest (P<0.01). We then reproduced the various exercise frequencies, tidal volumes, and ventilations during seated isocapnic hyperpnea to measure$\dot V_{{\text{O}}_{\text{2}} }$ with locomotory muscles at rest. Once again, oxygen uptake was constant, independent of breathing frequency. We conclude that the spontaneous exercise breathing frequency fails to minimize$\dot V_{{\text{O}}_{\text{2}} }$ during either exercise or resting reproduction of exercise ventilation.