Abstract
The mechanisms of the elevation of serum IgA levels in anaphylactoid purpura were investigated. Serum IgA levels were significantly elevated within 2 weeks (5 to 14 days for all 12 patients) after onset in patients with anaphylactoid purpura. Serum IgM and IgG were not elevated. Although the percentages of surface IgA-bearing cells were not increased in the patients, the numbers of IgA-secreting cells within 2 weeks after onset in the patients with anaphylactoid purpura were significantly higher than those of controls. In northern blot analysis on lymphocytes, the secreted α (αs)-chain gene was well expressed compared with the membrane-bound α (αm)-chain gene, within 2 weeks after the onset of anaphylactoid purpura. Therefore, stimulation by a certain agent or a certain immune response may accelerate expression of the αs-chain gene in anaphylactoid purpura.
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Kondo, N., Kasahara, K., Shinoda, S. et al. Accelerated expression of secreted α-chain gene in anaphylactoid purpura. J Clin Immunol 12, 193–196 (1992). https://doi.org/10.1007/BF00918088
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DOI: https://doi.org/10.1007/BF00918088