Skip to main content
SpringerLink
Log in

Response to measles-mumps-rubella vaccine in children on dialysis

  • Original Article
  • Published:
Pediatric Nephrology Aims and scope Submit manuscript

Abstract

Ten children receiving maintenance dialysis were immunized with the standard dose of measles-mumps-rubella vacine between 15 and 33 months of age. Immune responses to vaccination were determined using commercially available enzyme-linked immunosorbent assays for measles, mumps, and rubella viruses. Eight children responded to measles vaccine, 5 to mumps vaccine, 8 to rubella vaccine, and only 3 children to all three vaccines, compared with a seroconversion rate of over 90% to all three vaccines in healthy children (P<0.0001). We contend that the relatively poor immunocompetence of our dialysis patients explains their less than optimal vaccine response and suggest that children vaccinated while undergoing dialysis be tested to confirm serological evidence of immunity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Foreman JW, Chan JCM (1988) Chronic renal failure in infants and children. J Pediatr 113:793–800

    Google Scholar 

  2. Committee on Infectious Diseases (1991) Report of the Committee on Infectious Diseases, 22nd edn. American Academy of Pediatrics, Elk Grove Village, pp 319–320

    Google Scholar 

  3. Committee on Infectious Diseases, American Academy of Pediatrics (1989) Measles: reassessment of the current immunization policy. Pediatrics 84:1110–1113

    Google Scholar 

  4. Anagnostou A, Kurtzman NA (1986) Hematological consequences of renal failure. In: Brenner BM, Rector FC (eds) The kidney. Saunders, Philadelphia, pp 1631–1656

    Google Scholar 

  5. Grob P (1983) Hepatitis B vaccination of renal transplant and hemodialysis patients. Scand J Infect Dis [Suppl] 38:28–32

    Google Scholar 

  6. Stevens CE, Szmuness W, Goodman AI, Weseley SA, Fontino M (1980) Hepatitis B vaccine: immune response in haemodialysis patients. Lancet II:1211–1213

    Google Scholar 

  7. Dumann H, Meuer S, Meyer zum Buschenfelde KH, Köhler H (1990) Hepatitis B vaccination and interleukin 2 receptor expression in chronic renal failure. Kidney Int 38:1164–1168

    Google Scholar 

  8. Cosio FG, Giebink GS, Le CT, Schiffman G (1981) Pneumococcal vaccination in patients with chronic renal disease and renal allograft recipients. Kidney Int 20:254–258

    Google Scholar 

  9. Linnemann CC, First MR, Schiffman G (1986) Revaccination of renal transplant and hemodialysis recipients with pneumococcal vaccine. Arch Intern Med 146:1554–1556

    Google Scholar 

  10. Broyer M, Boudailliez B (1985) Varicella vaccine in children with chronic renal insufficiency. Postgrad Med J 61 [Suppl] 4:103–106

    Google Scholar 

  11. Arbeter AM, Starr SE, Plotkin SA (1986) Varicella vaccine studies in healthy children and adults. Pediatrics [Suppl] 78:748–756

    Google Scholar 

  12. Verslius DJ, Beyer WEP, Masurel N, Weimar W (1985) Influenza vaccination in dialysis and transplant patients. Antiviral Res [Suppl] 1:289–292

    Google Scholar 

  13. Brunell PA, Weigle K, Murphy MD, Shehab Z, Cobb E (1983) Antibody response following measles-mumps-rubella vaccine under conditions of customary use. JAMA 250:1409–1412

    Google Scholar 

  14. Deforest A, Gessner AR, Clark JL, Zahradnik JM (1989) Usefulness of enzyme-linked immunoassays (ELISA) in detecting seroconversion following measles-mumps-rubella (MMR) vaccines (abstract). Abstracts of the 89th Annual meeting of the American Society for Microbiology, 14–18 May 1989, American Society of Microbiology, New Orleans, p 136

  15. Kleiman MB, Blackburn CK, Zimmermean SE, French MLV (1981) Comparison of enzyme-linked immunosorbent assay for acute measles with hemagglutination inhibition, complement fixation, and fluorescent-antibody methods. J Clin Microbiol 14:147–152

    Google Scholar 

  16. Boteler WL, Luipersbeck PM, Buccillo DA, O'Beirne AJ (1983) Enzyme-linked immunosorbent assay for detection of measles antibody. J Clin Microbiol 17:814–818

    Google Scholar 

  17. Voller A, Bidwell DE (1976) Enzyme-immunoassays for antibodies in measles, cytomegalovirus infections, and after rubella vaccination. Br J Exp Pathol 57:243–247

    Google Scholar 

  18. Weigle KA, Murphy DM, Brunell PA (1983) Enzyme-linked immunosorbent assay for evaluation of immunity to measles virus. J Clin Microbiol 19:376–379

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, St. Christopher's Hospital for Children, Temple University School of Medicine, Philadelphia, Pennsylvania, USA

    Seth L. Schulman, Adamadia Deforest, Bruce A. Kaiser, Martin S. Polinsky & H. Jorge Baluarte

Authors
  1. Seth L. Schulman
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Adamadia Deforest
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Bruce A. Kaiser
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Martin S. Polinsky
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. H. Jorge Baluarte
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schulman, S.L., Deforest, A., Kaiser, B.A. et al. Response to measles-mumps-rubella vaccine in children on dialysis. Pediatr Nephrol 6, 187–189 (1992). https://doi.org/10.1007/BF00866312

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00866312

Key words

Search

Navigation