Summary
An electron-microscopic study of the glomeruli was made on 154 children with IgA nephropathy and no evidence of systemic disease, in whom immunofluorescence microscopy had shown diffuse mesangial deposition of IgA. Mesangial deposits were observed in all but eight children. Subepithelial deposits were observed in 40 children and were almost always accompanied by both mesangial and subendothelial deposits. Subepithelial deposits were significantly associated with more severe clinical presentations, a worse outcome and more severe light microscopic glomerular changes. These observations support the concept that IgA nephropathy is an immune complex disease.
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References
Berger J (1969) IgA glomerular deposits in renal disease. Transplant Proc 1:939–944
Clarkson AR, Seymour AE, Thompson AJ, Haynes WDG, Chan Y-L, Jackson B (1977) IgA nephropathy: a syndrome of uniform morphology, diverse clinical features and uncertain prognosis. Clin Nephrol 8:459–472
Davies DR, Tighe JR, Jones NF, Brown GW (1973) Recurrent haematuria and mesangial IgA deposition. J Clin Pathol 26:672–677
Finlayson G, Alexander R, Juncos L, Schlein E, Teague P, Waldmann R, Cade R (1975) Immunoglobulin A glomerulonephritis: a clinicopathologic study. Lab Invest 32:140–148
Germuth FG, Rodriguez E (1975) Focal mesangiopathic glomerulonephritis: prevalence and pathogenesis. Kidney Int 7:216–223
Hara M, Endo Y, Nihei H, Hara S, Fukushima O, Mimura N (1980) IgA nephropathy with subendothelial deposits. Virchows Arch [Pathol Anat] 386:249–263
Joshua H, Sharon Z, Gutglas E, Rosenfeld J, Ben-Bassat M (1977) IgA-IgG nephropathy: a clinicopathologic entity with slow evolution and favourable prognosis. Am J Clin Pathol 67:289–295
Levy M, Beufils H, Gubler MC, Habib R (1973) Idiopathic recurrent macroscopic hematuria and mesangial IgA-IgG deposits in children (Berger's disease). Clin Nephrol 1:63–69
Lowance DC, Mullins JD, McPahul JJ (1973) Immunoglobulin A (IgA) associated glomerulonephritis. Kidney Int 3:167–176
McCoy RC, Abramowsky CR, Tisher CC (1974) IgA nephropathy. Am J Pathol 76:123–144
Michalk D, Waldherr R, Seelig HP, Weber HP, Schärer K (1980) Idiopathic mesangial IgA-glomerulonephritis in childhood: description of 19 pediatric cases and review of the literature. Eur J Pediatr 134:13–22
Van de Putte LBA, De la Riviere GP, Van Breda-Vriesman JC (1974) Recurrent or persistent hematuria: sign of mesangial immune-complex deposition. New Eng J Med 290:1165–1170
Yoshikawa N, Uehara S, Yamana K, Ikeuchi H, Hiraumi M, Matsuo T, Odaka S (1980) Clinicopathological study of persistent asymptomatic proteinuria in children. Nephron 25:127–133
Yoshikawa N, White RHR, Cameron AH (1981) Prognostic significance of the glomerular changes in Henoch-Schoenlein nephritis. Clin Nephrol 16:223–229
Yoshikawa N, Matsuo T (1984) IgA nephropathy in children. Compre Therapy 10:35–41
Yoshikawa N, Hashimoto H, Katayama Y, Yamada Y, Matsuo T, Okada S (1984) The thin glomerular basement membrane in children with haematuria. J Pathol 142:253–257
Zimmerman StW, Burkholder PM (1975) Immunoglobulin A nephropathy. Arch Intern Med 135:1217–1223
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Yoshikawa, N., Ito, H., Nakahara, C. et al. Glomerular electron-dense deposits in childhood IgA nephropathy. Vichows Archiv A Pathol Anat 406, 33–43 (1985). https://doi.org/10.1007/BF00710555
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DOI: https://doi.org/10.1007/BF00710555