Summary
Three meningotheliomatous meningiomas showed prominent formation of hyaline inclusions (pseudopsammoma bodies). Immunocytochemical examination by means of indirect immunofluorescence and PAP techniques demonstrated strong labeling of these inclusions by antisera to human secretory component (SC), immunoglobulin (Ig) A and IgM. A similar staining pattern was found in intracytoplasmic globules of a metastatic carcinoma. Hyaline structures of various types in atypical, psammomatous, and hemangiopericytic meningiomas were not stained with the antisera employed.
By histochemical, immunocytochemical, and ultrastructural criteria, pseudopsammoma bodies in meningiomas are identical with intracytoplasmic inclusions of some epithelial neoplasms, especially of mammary and gastric carcinomas. Our study strongly corroborates Kepes' (1961, 1975) concept of secretory differentiation in meningiomas, and demonstrates an epithelial character at least of some meningiomas.
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References
Berard M, Tripier M-F, Choux R, Chrestian M-A, Hassoun J, Toga M (1978) Étude ultrastructurale des corps hyalins d'un méningiome pseudo-épithélial. Acta Neuropathol (Berl) 42:59–62
Brandtzaeg P (1981) Transport models for secretory IgA and secretory IgM. Clin Exp Immunol 44:221–232
Budka II, Popow-Kraupp Th (1981) Rabies and herpes simplex virus encephalitis. An immunohistological study on site and distribution of viral antigens. Virchows Arch A [Pathol Anat] 390:353–364
Cushing H, Eisenhardt L (1938) The meningiomas. Thomas, Springfield, IL
Font RL, Croxatto JO (1980) Intracellular inclusions in meningothelial meningioma. A histochemical and ultrastructural study. J Neuropathol Exp Neurol 39:575–583
Kepes J (1961) Observations on the formation of psammoma bodies and pseudopsammoma bodies in meningiomas. J Neuropathol Exp Neurol 20:255–262
Kepes J (1975) The fine structure of hyaline inclusions (pseudopsammoma bodies) in meningiomas. J Neuropathol Exp Neurol 34:282–289
Kock KF, Teglbjaerg PS (1981) Meningiomas with a nonmeningotheliomatous component. A new type of tumor? Acta Neuropathol (Berl) 55:199–203
Rascol MM, Izard JY (1978) Arachnoidea and subarachnoid spaces of the vault of the skull in man. Acta Neuropathol (Berl) 41:41–44
Stam FC, van Alphe HAM, Boorsma DM (1980) Meningioma with conspicuous plasma cell components. A histopathological and immunohistochemical study. Acta Neuropathol (Berl) 49:241–243
Syré G, Sehn M (1981) Intracellular storage of IgA and secretory component in carcinomas of the female breast. Virchows Arch A [Pathol Anat] 393:315–320
Syré G, Fellinger E, Krisch K (1981) Demonstration of secretory component and immunoglobulins within intracytoplasmic vacuoles in gastric cancer cells. Proc VIIIth Eur Congr Pathol, Helsinki, p 61
References
Harris JP, South MA (1981) Secretory component. A glandular epithelial cell marker. Am J Pathol 105:47–53
Wang N-S (1973) Electron microscopy in the diagnosis of pleural mesotheliomas. Cancer 31:1046–1054
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Dedicated to Professor Franz Seitelberger on the occasion of his 65th birthday
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Budka, H. Hyaline inclusions (pseudopsammoma bodies) in meningiomas: Immunocytochemical demonstration of epithel-like secretion of secretory component and immunoglobulins A and M. Acta Neuropathol 56, 294–298 (1982). https://doi.org/10.1007/BF00691261
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DOI: https://doi.org/10.1007/BF00691261