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Prospective and randomized clinical trial for the treatment of hepatocellular carcinoma — a comparison of lipiodol-transcatheter arterial embolization with and without Adriamycin (first cooperative study)

  • Session I: Treatment for Operable Patients Surgery and Combined Modalities
  • Hepatocellular Carcinoma Lipiodol-Transcatheterarteria Embolization, Adriamycir
  • Published:
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Summary

A randomized, controlled clinical trial comparing the use of lipiodol-transcatheter arterial embolization (L-TAE) in the presence versus the absence of Adriamycin (ADR) for the treatment of hepatocellular carcinoma was conducted from August 1988 through September 1989. In all, 125 Japanese hospitals participated in this study and 289 patients were entered in the trial. The patients were randomly allocated into group A (L-TAE) or group B (L-TAE+ADR) by telephone registration. There was no significant difference in background factors between group A and group B. Additional treatment, including repeated TAE or hepatic resection, was given to 189 patients. Among the four endpoints analyzed, the rate of tumor reduction and lipiodol accumulation in the tumor did not significantly differ between the two groups. The 3-year survival values for groups A and B were 33.6% and 34.9%, respectively; the difference was not significant. The serum alpha-fetoprotein level, however, decreased to a significantly greater extent in the group that received ADR than in the group that did not (P<0.05). This result suggests that ADR has some favorable additional effect in L-TAE for the treatment of hepatocellular carcinoma.

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References

  1. Hirai K, Kawazoe Y, Yamashita K, Aoki Y, Fujimoto T, Sakai T, Majima Y, Abe M, Tanikawa K (1989) Arterial chemotherapy and transcatheter arterial embolization therapy for non-resectable hepatocellular carcinoma. Cancer Chemother Pharmacol 23 (Suppl):S37

    Google Scholar 

  2. Kanematsu T, Furuta T, Takenaka K, Matsumata T, Yoshida Y, Nishizaki T, Hasuo K, Sugimachi K (1989) A 5-year experience of lipiodolization: selective regional chemotherapy for 200 patients with hepatocellular carcinoma. Hepatology 10:98

    Google Scholar 

  3. Kawai S, Okamura J, Ogawa M, Inoue, J, Ohashi Y, Kawarada Y, Kusano M, Kubo Y, Kuroda C, Sakata Y, Shimamura Y, Jinno K, Takahashi A, Takayasu K, Tamura K, Tani M, Nagasue N, Nakanishi Y, Makino M, Masuzawa M, Mikuriya S, Monden M, Yumoto Y, Mori T, Oda T (1992) An assessment of criteria for evaluating efficacy of L-TAE for the treatment of HCC (in Japanese). Acta Hepatol Jpn 33:86

    Google Scholar 

  4. Konno T, Maeda H, Iwai K, Tashiro S, Maki S, Morinaga T, Mochinaga M, Hiraoka T, Yokoyama I (1983) Effect of arterial administration of high-molecular-weight anticancer agent SMANCS with lipid lymphographic agent on hepatoma: a preliminary report. Eur J Cancer Clin Oncol. 19:1053

    Google Scholar 

  5. Lai CL, Wu PC, Chan GCB, Lok ASF, Lin HJ (1988) Doxorubicin versus no antitumor therapy in inoperable hepatocellular carcinoma. A prospective randomized trial. Cancer 62:479

    Google Scholar 

  6. Liver Cancer Study Group of Japan (1989) The general rules for the clinical and pathological study of primary liver cancer. Jpn J Surg 19:98

    Google Scholar 

  7. Nakamura H, Hashimoto T, Oi H, Sawada S (1989) Transcatheter oily chemoembolization of hepatocellular carcinoma. Radiology 170:783

    Google Scholar 

  8. Nomura F, Ohnishi K, Tanabe Y (1989) Clinical features and prognosis of hepatocellular carcinoma with reference to serum alphafetoprotein levels. Analysis of 606 patients. Cancer 64:1700

    Google Scholar 

  9. Ohishi H, Yoshimura H, Uchida, H, Sakaguchi H, Yoshioka T, Ohue S, Matsui T, Takaya A, Tsujii T (1989) Transcatheter arterial embolization using iodized oil (lipiodol) mixed with an anticancer drug for the treatment of hepatocellular carcinoma. Cancer Chemother Pharmacol 23 (Suppl):S33

    Google Scholar 

  10. Shimamura Y, Gunvén P, Takenaka, Y, Shimizu H, Shima Y, Akimoto H, Arima K, Takahashi A, Kitaya T, Matsuyama T, Hasegawa H (1988) Combined peripheral and central chemoembolization of liver tumors. Experience with lipiodol-doxorubicin and gelatin sponge (L-TAE). Cancer 61:238

    Google Scholar 

  11. Takayasu K, Shima Y, Muramatsu Y, Morivama N, Yamada T, Makuuchi M, Hasegawa H, Hirohashi S (1987) Hepatocellular carcinoma: treatment with intraarterial iodized oil with and without chemotherapeutic agents. Radiology 162:345

    Google Scholar 

  12. Takayasu K, Suzuki M, Uesaka K, Muramatsu Y, Moriyama N, Yoshida T, Yoshino M, Okazaki N, Hasegawa H (1989) Hepatic artery embolization for inoperable hepatocellular carcinoma; prognosis and risk factors. Cancer Chemother Pharmacol 23 (Suppl):S123

    Google Scholar 

  13. Tani M, Kawai S, Oda T (1990) Experience of transcatheter arterial chemoembolization with oral chemotherapy on HCC. (Excerpta Medica series on viral hepatitis and hepatocellular carcinoma, vol 57). Excerpta Medica, Hong Kong, p 623

    Google Scholar 

  14. Vetter D, Wenger JJ, Bergier JM, Doffoel M, Bockel R (1991) Transcatheter oily chemoembolization in the management of advanced hepatocellular carcinoma in cirrhosis: results of a Western comparative study in 60 patients. Hepatology 13:427

    Google Scholar 

  15. Yamashita Y, Takahashi M, Koga Y, Saito R, Nanakawa S, Hatanaka Y, Sato N, Nakashima K., Urata J, Yoshizumi K, Ito K, Sumi S, Kan M (1991) Prognostic factors in the treatment of hepatocellular carcinoma with transcatheter arterial embolization and arterial infusion. Cancer 67:385

    Google Scholar 

  16. Yang CF, Ho YZ, Chang JM, Chiang RH, Lai KH, Lee SD, Tsai YT, Lui WY, Liu TJ, Chen GH (1989) Transcatheter arterial chemoembolization for hepatocellular carcinoma. Cancer Chemother Pharmacol 23 (Suppl):S26

    Google Scholar 

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Authors and Affiliations

  1. Department of Surgery, National Medical Center Hospital, 1-21-1 Toyama, Shinjuku-ku, 162, Tokyo, Japan

    Saburo Kawai & Masayoshi Tani

  2. Osaka Teishin Hospital, Osaka, Japan

    Jun Okamura (Director)

  3. Aichi Cancer Center, Aichi, Japan

    Makoto Ogawa (Director)

  4. Dept. of Epidemiology and Biostatistics, School of Health Sciences, University of Tokyo, Tokyo, Japan

    Yasuo Ohashi

  5. National Oji Hospital, Oji, Japan

    Jushiro Inoue (Director Emeritus)

  6. The 1st Dept. of Surgery, Mie University, Mie, Japan

    Yoshifumi Kawarada

  7. The 2nd Dept. of Surgery, Asahikawa Medical College, Asahikawa, Japan

    Mitsuo Kusano

  8. Dept. of Internal Medicine, Omuta City Hospital, Omuta, Japan

    Yasuhiko Kubo

  9. Dept. of Radiology, The Center for Adult Diseases, Osaka, Japan

    Chikazumi Kuroda

  10. Dept. of Adult Diseases, Aomori Prefectural Central Hospital, Aomori, Japan

    Yu Sakata

  11. Dept. of Surgery, National Cancer Center Higashi Hospital, Tokyo, Japan

    Yoshiyuki Shimamura

  12. Dept. of Internal Medicine, National Shikoku Cancer Center, Shikoku, Japan

    Kenji Jinno

  13. Dept. of Internal Medicine, National Konodai Hospital, Konodai, Japan

    Akira Takahashi

  14. Dept. of Radiology, National Cancer Center Hospital, Tokyo, Japan

    Kenichi Takayasu

  15. Dept. of Internal Medicine, Miyazaki Prefectural Hospital, Miyazaki, Japan

    Kazuo Tamura

  16. The 2nd Dept. of Surgery, Shimane Medical School, Shimane, Japan

    Naofumi Nagasue

  17. Dept. of Surgery, Sapporo City Hospital, Sapporo, Japan

    Yoshimi Nakanishi

  18. Dept. of Radiology, National Minami-Kyushu Chuo Hospital, Minami-Kyushu, Japan

    Masaoki Makino

  19. Dept. of Gastroenterology, Osaka National Hospital, Osaka, Japan

    Manabu Masuzawa

  20. Dept. of Radiotherapy, National Medical Center Hospital, Tokyo, Japan

    Shuichi Mikuriya

  21. Dept. of Surgery II, Osaka University, Osaka, Japan

    Morito Monden & Takesada Mori

  22. Radioisotope Center, Okayama University, Okayama, Japan

    Yasuhiro Yumoto

  23. Japanese Red Cross Medical Center, Japan

    Toshitsugu Oda (Director)

Authors
  1. Saburo Kawai
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  2. Jun Okamura
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  3. Makoto Ogawa
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  4. Yasuo Ohashi
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  5. Masayoshi Tani
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  6. Jushiro Inoue
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  7. Yoshifumi Kawarada
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  8. Mitsuo Kusano
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  9. Yasuhiko Kubo
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  10. Chikazumi Kuroda
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  11. Yu Sakata
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  12. Yoshiyuki Shimamura
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  13. Kenji Jinno
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  14. Akira Takahashi
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  15. Kenichi Takayasu
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  16. Kazuo Tamura
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  17. Naofumi Nagasue
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  18. Yoshimi Nakanishi
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  19. Masaoki Makino
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  20. Manabu Masuzawa
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  21. Shuichi Mikuriya
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  22. Morito Monden
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  23. Yasuhiro Yumoto
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  24. Takesada Mori
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  25. Toshitsugu Oda
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Consortia

The Cooperative Study Group for Liver Cancer Treatment of Japan

Additional information

The Cooperative Study Group for Liver Cancer Treatment of Japan

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Kawai, S., Okamura, J., Ogawa, M. et al. Prospective and randomized clinical trial for the treatment of hepatocellular carcinoma — a comparison of lipiodol-transcatheter arterial embolization with and without Adriamycin (first cooperative study). Cancer Chemother. Pharmacol. 31 (Suppl 1), S1–S6 (1992). https://doi.org/10.1007/BF00687096

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  • DOI: https://doi.org/10.1007/BF00687096

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