Summary
A retrospective analysis of our patients with ankylosing spondylitis revealed a 17.8% incidence of recurrent hematuria. Two of the five patients with recurrent hematuria had previously undergone renal biopsies showing a focal proliferative glomerulonephritis. The only specimen examined by immunofluorescent staining showed the typical changes of IgA nephropathy. A control group of patients with rheumatoid arthritis did not show recurrent hematuria. Recurrent hematuria may be a frequent occurrence in ankylosing spondylitis and may signify the presence of one of the glomerulonephritides such as IgA nephropathy.
Similar content being viewed by others
References
Jennette J, Ferguson A, Moore M, Freeman D (1982) IgA nephropathy associated with seronegative spondyloarthropathies. Arthritis Rheum 25:144–149
Bailey R, Burry A, McGiven A, Kirk J, Laing J, Moller P (1980) A renal lesion in ankylosing spondylitis. Nephron 26:171–173
Malaviya A, Raina V, Mittal V (1981) Glomerulonephritis in seronegative spondyloarthritis syndrome. Arthritis Rheum 24:751–752
Isselbacher K, Adams R, Braunwald E, Petersdorf R, Wilson J (1980) Harrison's principles of internal medicine. McGraw Hill, New York
Bennett P, Burch T (1968) Population studies of the rheumatic diseases. Excerpta Medica, Amsterdam
Larcom R Jr, Carter G (1948) Erythrocytes in urinary sediment: Identification and normal limits. J Lab Clin Med 33:875–880
Ropes N, Bennett E, Cobb S, Jacox R, Jessar R (1958) Revision of diagnostic criteria for rheumatoid arthritis. Bull Rheum Dis 9:175–176
Pasternack A, Tallqrist G, Martio J (1970) Renal vascular changes in ankylosing spondylitis. Acta Med Scand 187: 519–523
Calin A (1975) Renal glomerular function in ankylosing spondylitis. Scand J Rheumatol 4:241–242
Lourie S, Deman S, Schroeder E (1977) association of renal papillary necrosis and ankylosing spondylitis. Arthritis Rheum 20:917–921
Smith P, Doll R (1982) Mortality among patients with ankylosing spondylitis after a single treatment course with x-rays. Br Med J 284:449–460
Sissons J, Woodrow D, Curtis J, Evans D, Gower P, Sloper J, Peters D (1975) Isolated glomerulonephritis with mesangial IgA deposits. Br Med J 3:611–614
Nyulassy S, Buc M, Sasinka M, Pavlovic M, Slugen I, Hirschova V, Kaiserova M, Menkyna R, Stefanovic J (1977) The HLA system in glomerulonephritis. Clin Immunol Immunopathol 7:319–23
Noel LH, Descamps B, Jungers P, Bach JF, Busson M, Suet C, Hors J, Dausset J (1978) HLA antigen in three types of glomerulonephritis. Clin Immunol Immunopathol 10:19–23
Brettle R, Peters DK, Batchelor JR (1978) Mesangial IgA glomerulonephritis and HLA antigens. N Engl J Med 299:200 (Letter)
Nahy J, Hamori A, Ambrus M, Hernadi E (1979) More on IgA glomerulonephritis and HLA antigens. N Engl J Med 300:92 (Letter)
Panayi G, Slaney J, Williams B (1980) Circulating immune complexes in patients with ankylosing spondylitis. Ann Rheum Dis 39:445–448
Rosenbaum J, Theofilopoulos A, McDevitt H, Pereira A, Carson D, Calin A, (1981) Presence of circulating immune complexes in Reiter's syndrome and ankylosing spondylitis. Clin Immunol Immunopathol 18:291–297
Cowling P, Ebringer R, Ebringer A (1980) Association of inflammation with raised serum IgA in ankylosing spondylitis. Ann Rheum Dis 39:545–549
Rifai A, Small P Jr, Teague P, Ayoub E (1979) Experimental IgA nephropathy. J Exp Med 150:1161–1173
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Wall, B.A., Agudelo, C.A. & Pisko, E.J. Increased incidence of recurrent hematuria in ankylosing spondylitis: a possible association with IgA nephropathy. Rheumatol Int 4, 27–29 (1984). https://doi.org/10.1007/BF00683881
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00683881