Summary
In newborn infants of various ages, the influence of repeated administration of water and electrolytes on renal excretion of urine, sodium, potassium, free and bound hydrogen ions and on urine osmolarity was studied. In 14- and 21-day-old infants the repeated administration of water and electrolytes was followed by diminution of renal excretion of hydrogen ions and potassium, possibly caused by stimulation of hormonal regulation of ion exchange in the kidney. In animal studies performed with a larger water and electrolyte load, stimulation of renal excretion of sodium was caused by the pretreatment.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Aperia, A., O. Broberger, K. Thodenius, R. Zetterström: Renal response to an oral sodium load in newborn full term infants. Acta paediat. scand.61, 670–676 (1972)
Aperia, A., O. Broberger, K. Thodenius, R. Zetterström: Developmental study of renal response to an oral salt load in preterm infants. Acta paediat. scand.63, 517–524 (1974)
Aperia, A., O. Broberger, K. Thodenius, R. Zetterström: Developmental of renal control of salt and fluid homeostasis during the first year of life. Acta paediat. scand.64, 393–402 (1975)
Bernhardt, G., H. Bräunlich, C. Dietze, W. Lungershausen, R. Schade: Beschleunigung der renalen Ausscheidung von p-Aminohippursäure bei Ratten verschiedenen Alters durch wiederholte Zufuhr von Fremdstoffen. Acta biol. med. germ.31, 423–434 (1973)
Bräunlich, H. In: Entwicklungspharmakologie (ed. H. Ankermann), pp. 127–154. Berlin: Volk und Gesundheit 1973
Bräunlich, H., R. Puschmann: Die Entwicklung der renalen Ausscheidung von Natrium und Kalium in der postnatalen Periode bei der Ratte. Acta biol. med. germ.29, 877–887 (1972)
Hirsch, G.H., J.B. Hook: Maturation of renal organic acid transport: substrate stimulation by penicillin and p-aminohippurate (PAH). J. Pharmacol. exp. Ther.171, 103–108 (1970)
Kersten, L., H. Bräunlich: Biologische Normalwerte bei Wistarratten (Jena) verschiedenen Alters. V. Die renale Wasser- und Elektrolytausscheidung. Z. Versuchstierk.10, 195–204 (1968)
Puschmann, R., H. Bräunlich: Die Aktivierung der renalen Kaliumausscheidung und die Verminderung der Kaliumtoxizität durch wiederholte Belastung mit KCl-Lösung bei Ratten verschiedenen Alters. Acta biol. med. germ.28, 89–98 (1972)
Steichen, J.J., J.J. Kleinman: Influence of dietary sodium intake on renal maturation in unanesthetized canine puppies. Proc. Soc. exp. Biol. Med.148, 748 (1975)
Traeger, A., G. Stein, Ch. Fritze, I. Bräunlich, H. Bräunlich: Untersuchungen zur Beschleunigung der renalen Ausscheidung von p-Aminohippursäure nach wiederholter Zufuhr bei verschieden alten Menschen. Dtsch. Gesundh.-Wes.29, 1129–1132 (1974)
Wrigth, F., N. Strieder, N. B. Fowler, G. Giebisch: Potassium secretion by distal tubule after potassium adaptation. Amer. J. Physiol.221, 437–448 (1971)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Frenzel, J., Bräunlich, H., Schramm, D. et al. Effect on maturation of kidney function in newborn infants of repeated administration of water and electrolytes. Eur J Clin Pharmacol 11, 317–320 (1977). https://doi.org/10.1007/BF00607683
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00607683