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Clozapine in tardive dyskinesia

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Abstract

Clozapine, which has had limited clinical testing in the U.S.A., was evaluated in 12 chronic schizophrenic patients with tardive dyskinesia. Its antipsychotic activity was again demonstrated and it suppressed the symptoms of tardive dyskinesia with a marked rebound occurring in these symptoms when it was withdrawn; there was no rigidity or other Parkinsonian symptoms. However, out of a total of 12 patients, neutropenia (800 and 1120) occurred in two patients, convulsions in one patient, marked withdrawal effects in three patients, and a hypotensive collapse with atrial fibrillation in one patient. If these adverse effects are confirmed in a larger sample size, then despite the novel desirable effects of clozapine it would seem unlikely that it will gain widespread or routine use1.

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References

  • Gershon, S.: Report of initial clinical trials of clozapine in acute schizophrenia. Presented at the International Symposium on Clozapine. New York (1974)

  • Gross, H., Langer, E.: Das Wirkungsprofil eines chemisch-neuartigen Breitband-Neuroleptikums der Dibenzodiazepingruppe. Wien. Med. Wochenschr.116, 814–816 (1966)

    Google Scholar 

  • Hippius, H., Stille, G.: Zur künftigen Entwicklung der Neuroleptika. In: Proceedings of the V world congress of psychiatry, Mexico, D. F. [November 25–December 4, 1971], part I [International Congress Series No. 274] R. de la Feunta and M. N. Weisman, eds., pp. 571–575. Amsterdam: Excerpta Medica 1973

    Google Scholar 

  • Overall, J. E., Gorham, D. R.: The brief psychiatric rating scale (BPRS). Psychol. Rep.10, 799–802 (1962)

    Google Scholar 

  • Rüther, E.: Leponex-Rundtischgespräch, Psychiatrische Klinik der FU Berlin (Berlin)14, 12 (1974)

    Google Scholar 

  • Simpson, G. M., Angus, J. W. D.: A rating scale for extrapyramidal side effects. Acta Psychiatr. Scand. [Suppl.]212, 11–19 (1970)

    Google Scholar 

  • Simpson, G. M., Varga, E.: Clozapine — a new antipsychotic agent. Curr. Ther. Res.16, 679–686 (1974)

    Google Scholar 

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Author notes

  1. George M. Simpson

    Present address: USC Metro Unit, Metropolitan State Hospital, 11400 So. Norwalk Blvd., 90650, Norwalk, CA, USA

Authors and Affiliations

  1. Rockland Research Institute, 10962, Orangeburg, New York, USA

    George M. Simpson, J. Hillary Lee & Ram K. Shrivastava

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  1. George M. Simpson
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  2. J. Hillary Lee
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  3. Ram K. Shrivastava
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Simpson, G.M., Lee, J.H. & Shrivastava, R.K. Clozapine in tardive dyskinesia. Psychopharmacology 56, 75–80 (1978). https://doi.org/10.1007/BF00571412

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  • DOI: https://doi.org/10.1007/BF00571412

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