Summary
Human plasma was incubated with cisplatin over 24h. Ultrafilterable platinum and platinum reactive with DDTC were determined at regular time intervals during incubation. At each time point more platinum reacted with sodiumN,N 1-diethyldithiocarbamate (DDTC) than was available as ultrafilterable platinum. At 24 h 70% of total platinum (10% ultrafiltrable platinum and 60% protein-bound platinum) reacted with DDTC. This means that cisplatin bound to plasma proteins can — at least in part — still react with strong nucleophiles.
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Hegedüs, L., van der Vijgh, W.J.F., Klein, I. et al. Chemical reactivity of cisplatin bound to human plasma proteins. Cancer Chemother. Pharmacol. 20, 211–212 (1987). https://doi.org/10.1007/BF00570487
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DOI: https://doi.org/10.1007/BF00570487