Skip to main content
Log in

The effect of hydroxyethylrutosides on capillary filtration rate in the lower limb of man

  • Originals
  • Published:
European Journal of Clinical Pharmacology Aims and scope Submit manuscript

Summary

The rate of capillary filtration in the lower limbs after hydroxyethylrutosides administered in various doses and by different routes was studied in patients with chronic venous insufficiency. Capillary filtration rate decreased immediately after intravenous and from 55 to 85 minutes after oral administration, depending on the dose. The slow-release tablets produced a definite falt in capillary filtration 240 minutes after administration.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Altura, B.M.: Do precapillary sphincters respond to vasoactive substances in an all-or-none manner? Proc. Soc. exp. Biol. Med.138, 273–276 (1971)

    Google Scholar 

  2. Fisher, R.A.: Statistical methods for research workers. 10th edn. New York: Stechert 1946

    Google Scholar 

  3. Hackett, A.M., Griffiths, L.A., Luyckx, A.S., van Cauwenberge, H.: Metabolism of hydroxyethylrutosides (HR). Arzneim. Forsch.26, 925–928 (1976)

    Google Scholar 

  4. Kappert, A.: Chronic venous insufficiency. In: Venous Diseases, Medical and Surgical Management, pp. 272–274, Montreux: Foundation International Cooperation in the Medical Sciences 1974

    Google Scholar 

  5. Kitchin, A.H.: Peripheral blood flow and capillary filtration rates. Brit. med. Bull.19, 155–160 (1963)

    Google Scholar 

  6. Krogh, A., Landis, E.M., Turner, A.H.: The movement of fluid through the human capillary wall in relation to venous pressure and to the colloid osmotic pressure of the blood. J. clin. Invest.11, 63–95 (1932)

    Google Scholar 

  7. Landis, E.M., Gibbon, J.H.: The effects of temperature and of tissue pressure on the movement of fluid through the human capillary wall. J. clin. Invest.12, 105–138 (1933)

    Google Scholar 

  8. Mellander, S., Öberg, B.: Transcapillary fluid absorption and other vascular reactions in the human forearm during reduction of the circulating blood volume. Acta physiol. scand.71, 37–46 (1967)

    Google Scholar 

  9. Mirkowitch, V., Robinson, J.W.L., Bel, F., Gumma, A.: Vergleichende Untersuchung am Hund zur Pharmakokinetik zweier Darreichungsformen mit der Wirksubstanz O-β-hydroxyethylrutosidea. Arzneim. Forsch.23, 3–8 (1973)

    Google Scholar 

  10. Přerovský, I., Roztočil, K., Hlavová, A., Koleilat, Z., Rázgová, L., Oliva, I.: The effect of hydroxyethylrutosides after acute and chronic oral administration in patients with venous diseases. Angiologia 9, 408–414 (1972)

    Google Scholar 

  11. Rázgová, L., Roztočil, K., Hálová, J., Fischer, A.: The effect of O-β-hydroxyethylrutosides (HR) on peripheral circulation of the lower extremities in idiopathic oedema. Europ. J. clin. Pharmacol.3, 247–251 (1971)

    Google Scholar 

  12. Roztočil, K., Fischer, A., Novák, P., Rázgová, L.: The effect of O-β-hydroxyethylrutosides (HR) on the peripheral circulation in patients with chronic venous insufficiency. Europ. J. clin. Pharmacol.3, 243–246 (1971)

    Google Scholar 

  13. Thulesius, O.: Capillary filtration under normal and pathological conditions. Angiologia10, 198–213 (1973)

    Google Scholar 

  14. Trap-Jensen, J., Clausen, J.P., Larsen, O.A.: Study on the acute effects of O-β-hydroxyethylrutosides (HR) on the increased muscle capillary permeability in long-term diabetics. Bibl. Anat.12, 398–403 (1973)

    Google Scholar 

  15. Whitney, R.J.: Measurement of volume changes in human limbs. J. Physiol. (London)121, 1–27 (1953)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Roztočil, K., Přerovský, I. & Oliva, I. The effect of hydroxyethylrutosides on capillary filtration rate in the lower limb of man. Eur J Clin Pharmacol 11, 435–438 (1977). https://doi.org/10.1007/BF00562934

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00562934

Key words

Navigation