Summary
The rate of capillary filtration in the lower limbs after hydroxyethylrutosides administered in various doses and by different routes was studied in patients with chronic venous insufficiency. Capillary filtration rate decreased immediately after intravenous and from 55 to 85 minutes after oral administration, depending on the dose. The slow-release tablets produced a definite falt in capillary filtration 240 minutes after administration.
Similar content being viewed by others
References
Altura, B.M.: Do precapillary sphincters respond to vasoactive substances in an all-or-none manner? Proc. Soc. exp. Biol. Med.138, 273–276 (1971)
Fisher, R.A.: Statistical methods for research workers. 10th edn. New York: Stechert 1946
Hackett, A.M., Griffiths, L.A., Luyckx, A.S., van Cauwenberge, H.: Metabolism of hydroxyethylrutosides (HR). Arzneim. Forsch.26, 925–928 (1976)
Kappert, A.: Chronic venous insufficiency. In: Venous Diseases, Medical and Surgical Management, pp. 272–274, Montreux: Foundation International Cooperation in the Medical Sciences 1974
Kitchin, A.H.: Peripheral blood flow and capillary filtration rates. Brit. med. Bull.19, 155–160 (1963)
Krogh, A., Landis, E.M., Turner, A.H.: The movement of fluid through the human capillary wall in relation to venous pressure and to the colloid osmotic pressure of the blood. J. clin. Invest.11, 63–95 (1932)
Landis, E.M., Gibbon, J.H.: The effects of temperature and of tissue pressure on the movement of fluid through the human capillary wall. J. clin. Invest.12, 105–138 (1933)
Mellander, S., Öberg, B.: Transcapillary fluid absorption and other vascular reactions in the human forearm during reduction of the circulating blood volume. Acta physiol. scand.71, 37–46 (1967)
Mirkowitch, V., Robinson, J.W.L., Bel, F., Gumma, A.: Vergleichende Untersuchung am Hund zur Pharmakokinetik zweier Darreichungsformen mit der Wirksubstanz O-β-hydroxyethylrutosidea. Arzneim. Forsch.23, 3–8 (1973)
Přerovský, I., Roztočil, K., Hlavová, A., Koleilat, Z., Rázgová, L., Oliva, I.: The effect of hydroxyethylrutosides after acute and chronic oral administration in patients with venous diseases. Angiologia 9, 408–414 (1972)
Rázgová, L., Roztočil, K., Hálová, J., Fischer, A.: The effect of O-β-hydroxyethylrutosides (HR) on peripheral circulation of the lower extremities in idiopathic oedema. Europ. J. clin. Pharmacol.3, 247–251 (1971)
Roztočil, K., Fischer, A., Novák, P., Rázgová, L.: The effect of O-β-hydroxyethylrutosides (HR) on the peripheral circulation in patients with chronic venous insufficiency. Europ. J. clin. Pharmacol.3, 243–246 (1971)
Thulesius, O.: Capillary filtration under normal and pathological conditions. Angiologia10, 198–213 (1973)
Trap-Jensen, J., Clausen, J.P., Larsen, O.A.: Study on the acute effects of O-β-hydroxyethylrutosides (HR) on the increased muscle capillary permeability in long-term diabetics. Bibl. Anat.12, 398–403 (1973)
Whitney, R.J.: Measurement of volume changes in human limbs. J. Physiol. (London)121, 1–27 (1953)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Roztočil, K., Přerovský, I. & Oliva, I. The effect of hydroxyethylrutosides on capillary filtration rate in the lower limb of man. Eur J Clin Pharmacol 11, 435–438 (1977). https://doi.org/10.1007/BF00562934
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00562934