Summary
Using NPase as a specific and differential marker of endothelial cells and some blood-borne cells, we attempted to provide information on the origin of cells contributing to the formation of the intimal thickening occuring during coronary collateral growth in the dog. NPase reactive endothelial cells, polymorphonuclear and mononuclear blood cells and NPase unreactive smooth muscle cells and modified smooth muscle cells were seen in variable proportions in the subendothelial space during the early period of vascular growth and in the intimal thickening, formed a few weeks later. The medial smooth muscle cell appeared to be the main progenitor of cells present in this zone.
The possible transformation of endothelial and blood-formed cells into myointimal cells is discussed. The functional significance of NPase activity in these cells and the further outlook of NPase application as a marker enzyme in the process of atherosclerosis, in experimental hypertension and in various vascular injury processes has been outlined.
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Supported by Grant 2034 of I.W.O.N.L.
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Borgers, M., Schaper, J. & Schaper, W. The origin of subendothelial cells in developing coronary collaterals. Virchows Arch. Abt. A Path. Anat. 358, 281–294 (1973). https://doi.org/10.1007/BF00543269
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DOI: https://doi.org/10.1007/BF00543269