Abstract
Ketamine is used extensively in the developing world (DW) because of its effectiveness, availability, relatively low cost, and presumed safety. This report is a prospective, objective assessment of the efficacy and safety of ketamine when used as the sole anesthetic agent in a general medical practice hospital in the DW in children less than 16 years of age undergoing nonemergent operative procedures. Children undergoing laparotomy, thoracotomy, or craniotomy were excluded. Data analysis included serial arterial hemoglobin saturation (SpO2) and pulse rate, amount of ketamine utilized, adequacy of anesthesia, and perioperative complications. One hundred thirty-one children undergoing a total of 210 anesthetics were studied. The level of anesthesia was adequate in all cases. The SpO2 dropped below 90% in 40 (19%) children, below 85% in 25 (12%), and below 80% in 13 (6%). SpO2 drops occurred significantly (P = 0.004) more often after IM than after IV injection. All drops in SpO2 were abrupt without premonitory signs. Thirty-three (82.5%) of these 40 children responded readily to airway manipulation with a jaw thrust, and only 7 (3.3% of the total series) required face-mask O2. None required intubation or positive-pressure ventilation. Transient laryngospasm occurred in 1 child, but there were no other complications. In particular, there was no mortality, apnea, emesis, excessive salivation, or significant early or delayed emergence phenomena. Ketamine is quite effective when used as the sole anesthetic agent in DW children. It is relatively safe, but hypoxemia may go undetected unless technologically sophisticated monitoring equipment is available. Proper suction and ventilatory support equipment should be readily available prior to ketamine injection. The first step when hypoxemia is detected is simple airway manipulation, followed by oxygen administration by face mask if needed. Rarely will intubation be indicated. Ketamine is also a good drug for the management of pediatric emergency department procedures in the United States, but all children in these more developed centers should be monitored with a pulse oximeter, since a significant number of children have a precipitous drop in SpO2.
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References
Dundee J (1990) Twenty-five years of ketamine. Anaesthesia 45: 159–160
Epstein F (1993) Ketamine dissociative sedation in pediatric emergency medical practice. Am J Emerg Med 11: 180–182
Green S, Johnson N (1990) Ketamine sedation for pediatric procedures: part 2, review and implications. Ann Emerg Med 19: 131–144
Green S, Nakamura R, Johnson N (1990) Ketamine sedation for pediatric procedures: part 1, a prospective series. Ann Emerg Med 19: 119–127
Green S, Rothrock S (1994) Intramuscular ketamine and apnea. Letter to the editor. Ann Emerg Med 23: 139–140
Kelly J, Brown R, Baumann R (1991) Sedation for pediatric laceration repair. Letter to the editor. Ann Emerg Med 20: 714–715
King M (1986) Dissociative anaesthesia. In: King M (ed) Primary anaesthesia. Oxford University Press, Oxford, pp 60–66
Leppaniemi A (1991) Where there is no anaesthetist. Br J Surg 78: 245–246
MacGowan W (1987) Surgical manpower worldwide. Bull Am Coll Surg 72: 5–7
Pederson L, Benumof J (1993) Incidence and magnitude of hypoxaemia with ketamine in a rural African hospital. Anaesthesia 48: 6749
Pender E, Pollack C, Fallis J (1991) Sedation for pediatric laceration repair. Letter to the editor. Ann Emerg Med 20: 713–714
Phillips L, Seruvatu S, Rika P, Tirikula V (1970) Anaesthesia for the surgeon anaesthetist in difficult situations. Anaesthesia 25: 3645
Reich D, Silvay G (1989) Ketamine: An update on the first twenty-five years of clinical experience. Can J Anaesth 36: 186–197
Schultz C, Green S, Rothrock S (1994) Intramuscular ketamine and apnea. Letter to the editor. Ann Emerg Med 23: 139
Smith J, Santer L (1993) Respiratory arrest following intramuscular ketamine injection in a 4-year-old child. Ann Emerg Med 22: 613–615
Walker A (1972) Intramuscular ketamine in a developing country. Anaesthesia 27: 408–414
White P, Way W, Trevor A (1982) Ketamine — its pharmacology and therapeutic uses. Anesthesiology 56: 119–136
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Meier, D.E., OlaOlorun, D.A., Nkor, S.K. et al. Ketamine. Pediatr Surg Int 11, 370–373 (1996). https://doi.org/10.1007/BF00497815
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DOI: https://doi.org/10.1007/BF00497815