Summary
Rat submandibular glands were exposed to fractionated irradiation of 50 Gy, as given comparably in clinical practice. The induced changes were compared by giving only irradiation or radiation in conjunction with stimulating the salivary glands with cyclocytidine prior to treatment. Cyclocytidine is an α-adrenergic agonist that effectively depletes the serous cells of their granules and their heavy metal content. Findings in the present study show that the administration of the drug prior to each irradiation reduces the radiation-induced destruction in the epithelial cells in the submandibular gland.
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References
Abok K, Brunk U, Jung B, Ericsson J (1984) Morphologic and histochemical studies on the differing radiosensitivity of ductular and acinar cells of the rat submandibular gland. Virchows Arch [B] 45:443–460
Cutler LS, Chaudry AP (1973) Release and restoration of the secretory granules in the convoluted tubules of the rat submandibular gland. Anat Rec 176:405–420
Dreizen S, Brown LR, Handler S, Levy BM (1976) Radiation-induced xerostomia in cancer patients. Cancer 38:273–278
Espinal EG, Rey BM de, Cabrini RL (1983) Radiation effects on submandibular gland of the rat. Stereological and ultrastructural study. Strahlentherapie 159:290–295
Greenspan D, Daniels TE (1987) Effectiveness of pilocarpine in postradiation xerostomia. Cancer 59:1123–1125
Messelt EB, Dahl E (1983) Influence of X-ray irradiation on the ultrastructure of rat submandibular gland striatedduct cells. Acta Odontol Scand 41:277–282
Norberg L, Abok K (1987) Effects of different alphaadrenergic and cholinergic agonists on the rat submaxillary gland. A light microscopical study. Arch Otorhinolaryngol 244:209–214
Norberg L, Forsberg B (1987) Alpha-adrenergic stimulation and radiosensitivity on the rat submaxillary gland. ORL 49:302–313
Norberg L, Lundquist PG (1988) An ultrastructural study of salivary gland radiosensitivity after alpha-adrenergic stimulation. Auris Nasus Larynx 15:1–17
Pratt NE, Sodicoff M (1972) Ultrastructural injury following x-irradiation of rat parotid gland acinar cells. Arch Oral Biol 17:1177–1186
Savage NW, Kruger BJ, Adkins KF (1985) The effects of fractionated megavoltage X-irradiation on rat submandibular gland. An assessment by electron microscopy. Aust Dent J 30:188–193
Savage NW, Kruger BJ, Adkins KF (1985) Rat submandibular gland microvasculature following fractionated megavoltage irradiation, Aust Dent J 30:99–103
Savage NW, Adkins KF, Kruger BJ (1985) The effects of fractionated megavoltage x-irradiation on rat submandibular gland: an assessment by light microscopy and autoradiography. Aust Dent J 30:1–7
Sodicoff M, Pratt NE, Sholley MM (1974) Ultrastructural radiation injury of rat parotid gland: a histopathologic dose-response study. Radiat Res 58:196–208
Wills ED (1970) Effects of irradiation on subcellular components. I. Lipid peroxide formation in the endoplasmic reticulum. Int J Radiat Biol 17:217–228
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Norberg, L.E., Lundquist, P.G. Aspects of salivary gland radiosensitivity: effects of sialagogues and irradiation. Arch Otorhinolaryngol 246, 200–204 (1989). https://doi.org/10.1007/BF00453662
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DOI: https://doi.org/10.1007/BF00453662