Abstract
Two healthy volunteers were treated with hypoxanthine 3×1 g and allopurinol 3×100 mg daily for 1 week. During this treatment serum oxypurine concentration and urinary oxypurine excretion increased as expected. No side effects were observed except for some mild daytime drowsiness and lethargy. Measurements of urinary serotonin (5-HT) excretion showed decreases to as much as 60% below initial values. Decreased urinary 5-HT excretion was also found in a patient with incomplete Lesch-Nyhan syndrome during treatment with high doses of hypoxanthine. His neurological symptoms improved slightly. The results suggest that high doses of hypoxanthine exert a nonspecific sedative effect on both patients with Lesch-Nyhan syndrome and healthy controls. The cause is probably a reduced synthesis or release of 5-HT.
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Abbreviations
- HGPRT:
-
hypoxanthine-guanine-phosphoribosyltransferase
- 5-HT:
-
5-hydroxytryptamine (serotonin)
References
Anders TF, Cann HM, Ciaranello RD, Barchas JD, Berger TA (1978) Further observations on the use of 5-hydroxytryptophan in a child with Lesch-Nyhan syndrome. Neuropädiatrie 9:157–166
Bakay B, Nissinen E, Sweetman L, Francke U, Nyhan WL (1979) Utilization of purines by an HPRT variant in an intelligent, nonmutilative patient with features of the Lesch-Nyhan syndrome. Pediatr Res 13:1365–1379
Beck O, Wiesel FA, Sedvall G (1977) Mass fragmentographic determination of 5-hydroxy-tryptamine and 5-hydroxyindole-3-acetic acid in brain tissue using deuterated internal standards. J Chromatogr 134:407–414
Brooks SC, Linn JJ, Disney N (1978) Serotonin, folic acid, and uric acid metabolism in the diagnosis of neuropsychiatric disorders. Biol Psychiatry 13:671–683
Evron S, Sadovsky E, Pfeifer Y, Sulman FG (1982) Plasma levels of serotonin compared with cortisol as indicators in gynecological operations. Isr J Med Sci 18:806–808
Ho HH, Lockitch G, Eaves L (1986) Blood serotonin concentrations and fenfluramine therapy in autistic children. J Pediatr 108: 465–469
Kuhn DM, Wolf WA, Lovenberg W (1980) Review of the role of the central serotonergic neuronal system in blood pressure regulation. Hypertension 2:243–255
Lloyd KG, Hornykiewicz O, Davidson L, Shannak K, Farley I, Goldstein M, Shibuya M, Kelley WN, Fox IH (1981) Biochemical evidence of brain neurotransmitters in the Lesch-Nyhan syndrome. N Engl J Med 305:1106–1111
Lou HC, Güttler F, Lykkelund C, Bruhn P, Niederwieser A (1985) Decreased vigilance and neurotransmitter synthesis after discontinuation of dietary treatment for phenylketonuria in adolescents. Eur J Pediatr 144:17–20
Manzke H, Gustmann H, Koke HG, Nyhan WL (1986) Hypoxanthine and tetrahydrobiopterin treatment of a patient with features of the Lesch-Nyhan syndrome. Adv Exp Med Biol 195A:p 197–203
Niklasson F, Agren H, Hällgren R (1983) Purine and monoamine metabolites in cerebrospinalfluid: parallel purinergic and mono-aminergic activation in depressive illness? J Neurol Neurosurg Psychiatry 46:255–260
Page T, Bakay B, Nissinen E, Nyhan WL (1981) Hypoxanthine-Guanine phosphoribosyltransferase variants: correlation of clinical phenotype with enzyme activity. J Inherited Metab Dis 4:203–206
Silverstein F, Johnston MV (1984) Cerebrospinal fluid mono-amine metabolites in patients with infantile spasms. Neurology 34:102–105
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Manzke, H., Gustmann, H. Reduced urinary serotonin excretion after intake of high doses of hypoxanthine. Eur J Pediatr 148, 337–340 (1989). https://doi.org/10.1007/BF00444129
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DOI: https://doi.org/10.1007/BF00444129