Abstract
Fifteen children with haematological diseases received an average of 10 granulocyte transfusions each, with 4.7×1010 granulocytes per m2 body surface area (BSA) per transfusion. All patients except one had less than 100 granulocytes per μl blood combined with aplasia or hypoplasia of granulopoiesis. Thirteen patients were transfused therapeutically because of fever and/or severe local lesions unresponsive to antibiotic therapy. Two patients, who were transfused prophylactically after bone-marrow transplantation (BMT), were in excellent clinical condition during the entire period of granulocyte transfusions in spite of severe granulocytopenia. All patients except one showed definite clinical benefit from granulocyte transfusions. The non-responding patient had leukocyte antibodies.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Alavi JB, Root RK, Djerassi I, Evans AE, Gluckman SJ, MacGregor RR, Guerry D, Schreiber AD, Shaw JM, Koch P, Cooper RA (1977) A randomized clinical trial of granulocyte transfusions for infection in acute leukemia. New Engl J Med 296:706–711
Arnold R, Pflieger H, Dietrich M, Heimpel H (1977) The clinical efficacy of granulocyte transfusions: studies on the oral cavity. Blut 35:405–415
Arnold R, Goldmann SF, Pflieger H (1980) Lymphocytotoxic antibodies in patients receiving granulocyte transfusions. Vox Sang 38:250–258
Athens JW (1970) Neutrophilic granulocyte kinetics and granulocytopoiesis. In: Gordon AS (ed), Regulation of hematopoiesis. Appleton-Century-Crofts, New York, pp 1143–1166
Berkman EM, Eisenstaedt RS, Caplan SN (1978) Supportive granulocyte transfusion in the infected severely neutropenic patient. Transfusion 18:693–700
Bhaduri S, Arnold R, Pflieger H, Krieger D (1979) The effect of granulocyte transfusions on the bacterial flora of haematological patients under gnotobiotic care. In: Fliedner TM, Heit H, Niethammer D, Pflieger H (eds) Clinical and experimental gnotobiotics. Zentralbl Bakteriol, Suppl 7: 389–393
Bodey GP, Buckley M, Sathe YS, Freireich EJ (1966) Quantitative relationships between circulating leukocytes and infections in patients with acute leukemia. Ann Int Med 64:328–340
Boggs DR (1977) Neutrophils in the blood bank. New Engl J Med 296:748–750
Curtis JE, Hasselback R, Bergsagel DE (1977) Leukocyte transfusions for the prophylaxis and treatment of infections associated with granulocytopenia. Can Med Ass J 117:341–345
Fortuny IE, Bloomfield CD, Hadlock DC, Goldman A, Kennedy BJ, McCullough JJ (1975) Granulocyte transfusion: a controlled study in patients with acute nonlymphocytic leukemia. Transfusion 15:548–558
Graw RG Jr, Herzig G, Perry S, Henderson ES (1972) Normal granulocyte transfusion therapy. New Engl J Med 287:367–371
Hershko C, Naparstek E, Eldor A, Izak G (1978) Granulocyte transfusion therapy. A clinical trial in patients with acute leukemia and sepsis. Vox Sang 34:129–135
Herzig RH, Herzig GP, Graw RG, Bull MI, Ray KK (1977) Successful granulocyte transfusion therapy for gram-negative septicemia. New Engl J Med 296:701–705
Higby DJ, Yates JW, Henderson ES, Holland JF (1975) Filtration leukapheresis for granulocyte transfusion therapy. New Engl J Med 292:761–766
Higby DJ, Freeman A, Henderson ES, Sinks L, Cohen E (1976) Granulocyte transfusions in children using filter-collected cells. Cancer 38:1407–1413
Lowenthal RM, Goldman JM, Buskard NA, Murphy BC, Grossman L, Storring RA, Park DS, Spiers ASD, Galton DAG (1975) Granulocyte transfusions in treatment of infections in patients with acute leukaemia and aplastic anaemia. Lancet I:353–358
Marsh JC, Boggs DR, Cartwright GE, Wintrobe MM (1967) Neutrophil kinetics in acute infection. J Clin Invest 46:1943–1953
Maybee DA, Millan AP, Ruymann FB (1977) Granulocyte transfusion therapy in children. South Med J 70:320–324
Pflieger H, Arnold R, Dietrich M, Goldmann SF, Niethammer D (1977) High dose granulocyte substitution after bone marrow transplantation in a case of aplastic anaemia in childhood. Helv paediat Acta 32:241–249
Pflieger H, Dietrich M, Arnold R, Wildfeuer A (1978) High granulocyte yield with a simple method of filtration leukapheresis. Klin Wochenschr 56:409–414
Pflieger H, Arnold R, Bhaduri S, Bültmann B, Goldmann SF, Haghou F, Kubanek B, Kurrle E, Niethammer D (1979) Beneficial effect of granulocyte transfusions in patients with defects in granulocyte function and severe infections. Scand J Haematol 22:33–41
Pflieger H, Gaus W, Dietrich M (1979) Differential blood counts from cell concentrates: a comparison with routine differential blood counts. Acta haematol 61:150–154
Pflieger H, Arnold R, Bhaduri S, Haghou F, Heimpel H (1979) Parameters for determining the clinical efficacy of granulocyte transfusion therapy. In: Mandelli F (ed) Therapy of acute leukemias. Proceedings of the 2nd International Symposium. Lombardo Editore, Rom, pp 631–635
Pole JG, Davie M, Kershaw J, Barter DAC, Willoughby MLN (1976) Granulocyte transfusion in treatment of infected neutropenic children. Arch Dis Child 51:521–527
Rodriguez V, Bodey GP (1976) Antibacterial therapy—special considerations in neutropenic patients. Clin Haematol 5:347–360
Strauss RG (1978) Therapeutic neutrophil transfusions. Are controlled studies no longer appropriate? Am J Med 65:1001–1006
Terasaki PI, Park MS (1976) Microdroplet lymphocyte cytotoxicity test. In: Ray GB, Hare DB, Pedersen DB, Mullaly DJ (eds) NIAID manual of tissue typing techniques 1976–1977. NIH/USA
Vogler WR, Winton EF (1977) A controlled study of the efficacy of granulocyte transfusions in patients with neutropenia. Am J Med 63:548–555
Author information
Authors and Affiliations
Additional information
Supported by Deutsche Forschungsgemeinschaft, SFB 112
Rights and permissions
About this article
Cite this article
Pflieger, H., Wiesneth, M., Arnold, R. et al. Granulocyte transfusions in children. Eur J Pediatr 135, 261–266 (1981). https://doi.org/10.1007/BF00442100
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00442100