Skip to main content
SpringerLink
Log in

Gene therapy of malignant glioma via inhibition of tumor angiogenesis

  • Tumor Angiogenesis
  • Published:
Cancer and Metastasis Reviews Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Folkman J: What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 82: 4–6, 1990

    Google Scholar 

  2. Folkman J, Hanahan D: Expression of the angiogenic phenotype during development of murine and human cancer. In: Origins of human cancer: A comprehensive review, Cold Spring Harbor Laboratory Press, 1991, pp 803–814

  3. Leung DW, Cachianes G, Kuang W-J, Goeddel DV, Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246: 1306–1309, 1989

    Google Scholar 

  4. Conolly DT, Heuvelman DM, Nelson R, Olander JV, Eppley BL, Delfino JJ, Siegel NR, Leimgruber RM, Feder J: Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis. J Clin Invest 84: 1470–1478, 1989

    Google Scholar 

  5. Keck PJ, Hauser S, Krivi G, Sanzo K, Warren T, Feder J, Conolly DT: Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 246: 1309–1312, 1989

    Google Scholar 

  6. Alon T, Hemo I, Itin A, Peér J, Stone J, Keshet E: Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nature Medicine 1: 1024–1028, 1995

    Google Scholar 

  7. Plate KH, Breier G, Weich HA, Risau W: Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature 359: 845–848, 1992

    Google Scholar 

  8. Plate KH, Risau W: Angiogenesis in malignant gliomas. Glia 15: 339–347, 1995

    Google Scholar 

  9. Shweiki D, Itin A, Soffer D, Keshet E: Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359: 843–845, 1992

    Google Scholar 

  10. Ikeda E, Achen MG, Breier G, Risau W: Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells. J Biol Chem 270: 19761–19766, 1995

    Google Scholar 

  11. De Vries C, Escobedo JA, Ueno H, Houck K, Ferrara N, Williams LT: The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 255: 989–991 1992

    Google Scholar 

  12. Terman BC, Dougher-Vermazen M, Carrion ME, Dimitrov D, Armellino DC, Gospodarowicz D, Böhlen P: Identification of the KDR tyrosine kinase as a receptor for vascular endothelial growth factor. Biochem Biophys Res Commun 187: 1579–1586, 1992

    Google Scholar 

  13. Millauer B, Wizigmann-Voos S, Schnürch H, Martinez R, Moller NPH, Risau W, Ullrich A: High affinity VEGF binding and developmental expression suggests flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 72: 835–846, 1993

    Google Scholar 

  14. Plate KH, Breier G, Weich HA, Mennel HD, Risau W: Vascular endothelial growth factor and glioma angiogenesis: coordinate induction of VEGF receptors, distribution of VEGF protein and possible in vivo regulatory mechanisms. Int J Cancer 59: 520–529, 1994

    Google Scholar 

  15. Plate KH, Breier G, Millauer B, Ullrich A, Risau W: Upregulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogenesis. Cancer Res 53: 5822–5827, 1993

    Google Scholar 

  16. Kim JB, Li B, Winer J, Armanini M, Gillett N, Phillips HS, Ferrara N: Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 362: 841–844, 1993

    Google Scholar 

  17. Millauer B, Shawver L, Plate KH, Risau W, Ullrich A: Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant. Nature 367: 576–578, 1994

    Google Scholar 

  18. Peters KG, de Vries C, Williams LT: Vascular endothelial growth factor receptor expression during embryogenesis and tissue repair suggests a role in endothelial cell differentiation and blood vessel growth. Proc Natl Acad Sci USA 90: 8915–8919, 1993

    Google Scholar 

  19. Fong G-H, Rossant J, Gertsenstein M, Breitman ML: Role of the flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 376: 66–70, 1995

    Google Scholar 

  20. Shalaby F, Rossant J, Yamaguchi TP, Gertsenstein M, Wu X-F, Breitman ML, Schuh AC: Failure of blood-island formation and vasculogenesis in flk-1 deficient mice. Nature 376: 62–66, 1995

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Neurocenter, Department of Neuropathology, University of Freiburg Medical School, Freiburg, Germany

    Karl H. Plate

Authors
  1. Karl H. Plate
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Plate, K.H. Gene therapy of malignant glioma via inhibition of tumor angiogenesis. Cancer Metast Rev 15, 237–240 (1996). https://doi.org/10.1007/BF00437477

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00437477

Key words

Search

Navigation