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Paecilotoxin production in clinical or terrestrial isolates of Paecilomyces lilacinus strains

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Abstract

The production of paecilotoxin from various isolates of Paecilomyces lilacinus was studied using three different media and high performance liquid chromatography (HPLC). Alkaline medium was found to be suitable for the production of the toxins. Among 20 strains tested, 19 including four clinical isolates were found to produce the toxins. Production patterns of paecilotoxins were very similar in each strain and the main toxins were A and B.

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References

  1. Rockhill RC, Klein MD. Paecilomyces lilacinus as the cause of chronic maxillary sinusitis. J Clin Microbiol 1980; 11: 737–739.

    Google Scholar 

  2. Maslen M, Whitehead J, Forsyth WM, McCracken H, Hocking AD. Systemic mycotic disease of captive crocodile hatching (Crocodylus porosus caused by Paecilomyces lilacinus. J Med Vet Mycol 1988; 26: 219–225.

    Google Scholar 

  3. Arai M, Mikami Y, Fukushima K, Utsumi T, Yazawa K. A new antibiotic, leucinostatin, derived from Penicillium lilacinum. J Antibiot 1973; 26: 157–161.

    Google Scholar 

  4. Mikami Y, Fukushima K, Arai T, Abe F, Shibuya H, Ommunra Y. Leucinostatins, peptide mycotoxins produced by Paecilomyces lilacinus and their possible roles in fungal infections. Zbl Bakt Hyg 1984; 257: 275–283.

    Google Scholar 

  5. Stroh JG, Rinehart KL, Cook JC, Kihara T, Suzuki M, Arai T. Identification and structure assignment of components of leucinostatin and CC-1014 by directly coupled liquid chromatography/fast atom bombardment mass spectrometry. J Amer Cheni Soc 1986; 108: 858–859.

    Google Scholar 

  6. Mori Y, Suzuki M, Fukushima K, Arai T. Structure of leucinostatin B, an uncoupler on mitochondria. J Antibiot 1983; 36: 1084–1086.

    Google Scholar 

  7. Radics L, Kajatar-Peredy M, Gasinovi CG, Rossi C, Ricc M, Tuttobello L. Leucinostatins H and K, two novel peptide antibiotics with tertiary amine-oxide terminal group from Paecilomyces marquandii. Isolation, structure and biological activity. J Antibiot 1987; 40: 714–716.

    Google Scholar 

  8. Mikami Y, Fukushima K, Samson RA, Udagawa S, Arai T. Paecilotoxins, etiological agents of fungal infection. Proc. Xth ISHAM Congress, Barcelona. 1988; 128–132.

  9. Samson RA. Paecilomyces and some allied hyphomycetes. Studies in Mycology No. 6: 1–119 (Centraalbureau voor Schimmelcultures, Baarn), 1974.

    Google Scholar 

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Authors and Affiliations

  1. Department of Experimental Chemotherapy, Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, 1-8-1, Inohana, 280, Chiba, Japan

    Yuzuru Mikami, Katsukiyo Yazawa, Kazutaka Fukushima & Tadashi Arai

  2. Division of Microbiology, National Institute of Hygienic Sciences, 1-18-1, Kamiyoga, Setagaya-ku, 158, Tokyo, Japan

    Shun-ichi Udagawa

  3. Centraalbureau voor Schimmelcultures, 3740, AG Baarn, The Netherlands

    Robert A. Samson

Authors
  1. Yuzuru Mikami
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  2. Katsukiyo Yazawa
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  3. Kazutaka Fukushima
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  4. Tadashi Arai
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  5. Shun-ichi Udagawa
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  6. Robert A. Samson
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Mikami, Y., Yazawa, K., Fukushima, K. et al. Paecilotoxin production in clinical or terrestrial isolates of Paecilomyces lilacinus strains. Mycopathologia 108, 195–199 (1989). https://doi.org/10.1007/BF00436225

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  • DOI: https://doi.org/10.1007/BF00436225

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