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Interactions between sympathomimetic amines and a new monoamine oxidase inhibitor

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Abstract

A relatively safe method is described for the screening of new monoamine oxidase inhibitors with respect to their potentiation of dietary and sympathomimetic amines. Studies of such a compound, Clorgyline, and its interactions with oral tyramine and phenylephrine given by mouth to three doctor-volunteers are described. Marked potentiation of the bradycardia-inducing properties of the amines was found.

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Author notes

  1. M. Tansella

    Present address: Psychiatric Clinic of Verona, University of Padua, Italy

Authors and Affiliations

  1. The Institute of Psychiatry, de Crespigny Park, Denmark Hill, London S.E. 5

    M. H. Lader, G. Sakalis & M. Tansella

Authors
  1. M. H. Lader
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  2. G. Sakalis
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  3. M. Tansella
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Lader, M.H., Sakalis, G. & Tansella, M. Interactions between sympathomimetic amines and a new monoamine oxidase inhibitor. Psychopharmacologia 18, 118–123 (1970). https://doi.org/10.1007/BF00402391

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  • DOI: https://doi.org/10.1007/BF00402391

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