Skip to main content
SpringerLink
Log in

Effects of dietary calcium, magnesium and phosphorus on the formation of struvite stones in the urinary tract of rats

  • Original Articles
  • Published:
Urological Research Aims and scope Submit manuscript

Summary

After feeding various diets we studied the effects of dietary calcium, magnesium and phosphorus on the formation of struvite stones in rats with urinary tract infections, and also studied the effects of the administration of vitamin D3 and aluminium gel on stone formation. A low-magnesium diet decreased urinary magnesium and prevented stone formation, but a medium-calcium diet did not significantly decrease stone weight. A high-calcium diet decreased urinary phosphorus and inhibited stone formation. A high-calcium and high-phosphorus diet decreased urinary excretion of magnesium and inhibited stone formation. Although the administration of vitamin D3 did not inhibit stone formation, aluminium gel decreased the urinary level of phosphorus and prevented stone formation. A marked decrease in urinary magnesium and/or phosphorus may prevent struvite stone formation in rats with urinary tract infections.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Brockis JG, Levitt AJ, Cruthers S (1982) The effects of vegetable and animal protein diets on calcium, urate and oxalate excretion. Br J Urol 54:509

    Google Scholar 

  2. Ebisuno S, Morimoto S, Fukatani T, Miyazaki Y, Yasukawa S, Sawada Y, Ohkawa T (1985) Studies of experimental calcium oxalate stone: 1. The affection of calcium and magnesium of renal deposition of calcium oxalate induced by ethylene glycol administration (in Japanese). Jpn J Urol 76:831

    Google Scholar 

  3. Fukuda K, Tanaka M, Tanase H, Muramatsu Y, Mizuhara V (1984) X-ray microanalysis of spontaneously formed urinary calculi in a jaundiced strain of rat. Exp Mol Pathol 40:21

    Google Scholar 

  4. Gershoff SN, Andrus SB (1961) Dietary magnesium, calcium and vitamin B6 and experimental nephropathies in rats: calcium oxalate calculi, apatite nephrocalcinosis. J Nutr 73:308

    Google Scholar 

  5. Gill WB, Finlayson B, Vermeulen CW (1959) Prevention of urinary calculi in rats by adding calcium to the diet: experimental urolithiasis 16. J Urol 82:256

    Google Scholar 

  6. Griffith DP, Musher DM (1973) Prevention of infected urinary stones by urease inhibition. Invest Urol 11:228

    Google Scholar 

  7. Johansson G, Backman U, Danielson BG, Fellstrom B, Ljunghall S, Wikstrom B (1980) Biochemical and clinical effects of the prophylactic treatment of renal calcium stones with magnesium hydroxide. J Urol 124:770

    Google Scholar 

  8. Lavengood RW Jr, Marshal VF (1972) The prevention of renal phosphatic calculi in the presence of infection by the shorr regimen. J Urol 108:368

    Google Scholar 

  9. Pak CYC, Smith LH, Resnick MI, Weinert JL (1984) Dietary management of idiopathic calcium urolithiasis. J Urol 131:850

    Google Scholar 

  10. Resnick MI (1981) Evaluation and management of infection stones. Urol Clin North Am 8:265

    Google Scholar 

  11. Robertson WG, Peacock M, Heyburn PJ, Hanes FA, Rutherford A, Clementson E, Swaminathan R, Clark PB (1979) Should recurrent calcium oxalate stone formers become vegetarians? Br J Urol 51:427

    Google Scholar 

  12. Satoh M, Munakata K, Kitoh K, Takeuchi H, Yoshida O (1984) A newly designed model for infection induced badder stone formation in the rat. J Urol 132:1247

    Google Scholar 

  13. Shorr E, Carter AC (1950) Aluminium gels in the management of renal phosphatic calculi. JAMA 144:1549

    Google Scholar 

  14. Soriano F, Ponte C, Santamaria M, Castilla C, Femandez Roblans R (1986) In vitro and in vivo study of stone formation by Corynebacterium group D2 (Corynebacterium urealyticum). J Clin Microbiol 23:691

    Google Scholar 

  15. Takeuchi H, Kobashi K, Yoshida O (1980) Prevention of infected urinary stones in rats by urease inhibitor. A new hydroxamic acid derivative. Invest Urol 18:102

    Google Scholar 

  16. Takeuchi H, Takayama H, Konishi T, Tomoyoshi T (1984) Scanning electron nmicroscopy detects bacteria within infection stones. J Urol 132:67

    Google Scholar 

  17. Vermeulen CW, Goetz R (1954) Experimental urolithiasis 8: fradantin in treatment of experimental Proteus infection with stone formation. J Urol 72:88

    Google Scholar 

  18. Vermeulen CW, Lyon ES, Gill WB, Chapman WH (1959) Prevention of phosphate stones by phytate, phosphate and hexametaphosphate: experimental urolithiasis 15. J Urol 82:249

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of urology, Faculty of Medicine, Kyoto University, Kyoto, Japan

    H. Takeuchi, M. Ueda & O. Yoshida

  2. Eisai Research Laboratories, Tokyo, Japan

    M. Satoh

Authors
  1. H. Takeuchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Ueda
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Satoh
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. O. Yoshida
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Takeuchi, H., Ueda, M., Satoh, M. et al. Effects of dietary calcium, magnesium and phosphorus on the formation of struvite stones in the urinary tract of rats. Urol. Res. 19, 305–308 (1991). https://doi.org/10.1007/BF00299065

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00299065

Key words

Search

Navigation