Summary
The medial femoral cortices of 10 females with femoral neck fractures and 10 age-matched female autopsy cases were studied using computer-assisted videodensitometry. Radiographic mineral density was determined using the calibration method described by Martin et al. [20]. Measurements were made of porosity, osteon and haversian canal dimensions, and of interstitial and osteon mineral density across the cortical wall of the orthopedic calcar region. There were no differences between the fracture and nonfracture groups in the overall mean mineral density of the bone averaged over the microstructure, excluding pore space, or in the interstitial bone mineral density. The porosity in the fracture group was greater than in the autopsy group, especially in the periosteal region, where the porosity was 2.4 times greater and where there were also 27% fewer osteons per unit area than in the autopsy group (P<0.05). Mean osteon mineral density was 2.5% higher in the fracture group (P<0.05) compared with the autopsy group in the endosteal region, and 4% higher in the periosteal region. Osteon and haversian canal areas were also larger in the fracture group, especially in the middle region of the cortical wall (17% and 23%, respectively, P<0.05).
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References
Praemer A, Furner S, Rice DP (1992) Musculoskeletal conditions in the United States. American Academy of Orthopaedic Surgeons, Park Ridge, Illinois
Beck TJ, Ruff CB, Warden KE, Scott WW, Rao GU (1990) Predicting femoral neck strength from bone mineral data. A structural approach. Invest Radiol 25:6–25
Beck TJ, Ruff CB, Scott WW, Plato CC, Tobin JD, Quan CA (1992) Sex differences in geometry of the femoral neck with aging: a structural analysis of bone mineral data. Calcif Tissue Int 50:24–29
Dalen N, Hellstrom L-G, Jacobson B (1976) Bone mineral content and mechanical strength of the femoral neck. Acta Orthop Scand 47:503–508
Lotz JC, Hayes WC (1990) The use of quantitative computed tomography to estimate risk of fracture of the hip from falls. J Bone Joint Surg 72-A:689–700
Mizrahi J, Margulies JY, Leichter I, Deutsch D (1982) Role of porosity in fracture initiation of the femoral neck. In: Menczel J, Robin GC, Makin M, Steinberg R (eds) Osteoporosis. John Wiley & Sons New York, pp 181–188
Ruff CB, Hayes WC (1988) Sex differences in age-related remodelling of the femur and tibia. J Orthop Res 6:886–896
Brown TD, Ferguson AB (1980) Mechanical property distributions in the cancellous bone of the human proximal femur. Acta Orthop Scand 51:429–437
Lotz JC, Cheal EJ, Hayes WC (1992) Fracture prediction for the proximal femur using finite element models: part I. Linear analysis. J Biomech Eng 113:353–360
Mazess RB (1990) Fracture risk: a role for compact bone. Calcif Tissue Int 47:191–193
Dickenson RP, Hutton WC, Stott JRR (1981) The mechanical properties of bone in osteoporosis. J Bone Joint Surg 63B:233–238
Schaffler MB, Burr DB (1988) Stiffness of compact bone: effects of porosity and density. J Biomech 21:13–16
Wall JC, Chatterji SK, Jeffrey JW (1979) Age-related changes in the density and tensile strength of human femoral cortical bone. Calcif Tissue Int 27:105–108.
Albright F, Reifenstein EC (1948) The parathyroid glands and metabolic bone disease. Williams and Wilkins, Baltimore, MD, p 393
Fazzalari NL, Moore RJ, Manthey BA, Vernon-Roberts B (1989) Comparative study of iliac crest and proximal femur histomorphometry in normal patients. J Clin Pathol 42:745–748
Eventov I, Frisch B, Cohen Z, Hammel I (1991) Osteopenia, hematopoiesis, and bone remodelling in iliac crest and femoral biopsies: a prospective study of 102 cases of femoral neck fractures. Bone 12:1–6
Strid KG, Kalebo P (1988) Bone mass determination from microradiographs by computer-assisted videodensitometry: I. Methodology. Acta Radiol 29:465–472
Kalebo P, Strid KG (1988) Bone mass determination from microradiographs by computer-assisted videodensitometry: 2. Aluminum as a reference substance. Acta Radiol 29:611–617
Barth RW, Williams JL, Kaplan FS (1992) Osteon morphometry in patients with femoral neck fractures. Clin Orthop Rel Res 283:178–186
Martin RB, Papamichos T, Dannucci GA (1990) Linear calibration of radiographic mineral density using video-digitizing methods. Calcif Tissue Int 47:82–91
Kerley ER (1964) The microscopic determination of age in human bone. Am J Phys Anthrop 23:149–164
Simmons ED Jr, Pritzker KPH, Grynpas MD (1991) Age-related changes in the human femoral cortex. J Orthop Res 9:155–167
Zanelli JM, Bradbeer JN, Moyes S, Wand JS, Roux J-P, Green JR, Arlot ME, Meunier PJ, Reeve J (1992) Microstructural characteristics and remodelling of bone in the neck of femur at the time of fracture. Bone Miner 17 (suppl 1):145
Smith JW, Walmsley R (1959) Factors affecting the elasticity of bone. J Anat 93:503–523
Jowsey J (1964) Variations in bone mineralization in age and disease. In: Frost HM (ed) Bone biodynamics. Little, Brown, and Company, Boston, MA: pp 461–479
Vose GP (1962) Quantitative microradiography of osteoporotic compact bone. Clin Orthop Rel Res 85:206–212
Black J, Mattson R, Korostoff E (1974) Haversian osteons: size, distribution, internal structure, and orientation. J Biomed Mater Res 8:299–319
Laval-Jeantet A, Bergor C, Caroll R, Garcia-Schaefer F (1983) Cortical bone senescence and mineral bone density of the humerus. Calcif Tissue Int 35:268–272
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Squillante, R.G., Williams, J.L. Videodensitometry of osteons in females with femoral neck fractures. Calcif Tissue Int 52, 273–277 (1993). https://doi.org/10.1007/BF00296651
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DOI: https://doi.org/10.1007/BF00296651