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A complex balanced chromosomal rearrangement in repeated abortions

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Summary

A double balanced reciprocal translocation involving four chromosomes, t(1;19;6;14) (1p11; 19p11; 6q25; 14q21), was found in the phenotypically normal husband in a couple referred because of repeated abortions. Reciprocal translocations, t(6;14), had been transmitted by his mother, his father being apparently homozygous for a translocation comprising pairs 1 and 19-t(1;19)(1;19). The genetic consequences of this complex chromosomal rearrangement are analyzed.

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Authors and Affiliations

  1. Department of Medical Genetics, Faculty of Medicine, University of Porto, P-4200, Porto, Portugal

    Alberto Barros, M. Carmo Tavares, Sérgio Castedo, M. Salomé Pereira & M. Purificação Tavares

  2. Júlio Dinis Maternity Hospital, Oporto, Portugal

    M. Almeida e Costa

Authors
  1. Alberto Barros
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  2. M. Carmo Tavares
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  3. Sérgio Castedo
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  4. M. Salomé Pereira
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  5. M. Purificação Tavares
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  6. M. Almeida e Costa
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Barros, A., Carmo Tavares, M., Castedo, S. et al. A complex balanced chromosomal rearrangement in repeated abortions. Hum Genet 75, 388–390 (1987). https://doi.org/10.1007/BF00284115

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  • DOI: https://doi.org/10.1007/BF00284115

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