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Myotonic dystrophy is closely linked to the gene for muscle-type creatine kinase (CKMM)

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Summary

We have studied genetic linkage between the gene for creatine kinase muscle type (CKMM) and the gene for myotonic dystrophy (DM). In a panel of 65 myotonic dystrophy families from Canada and the Netherlands, a maximum lod score (Zmax) of 22.8 at a recombination frequency (Θ) of 0.03 was obtained. Tight linkage was also demonstrated for CKMM and the gene for apolipoprotein C2 (ApoC2). This establishes CKMM as a useful marker for myotonic dystrophy.

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Authors and Affiliations

  1. Department of Human Genetics, University of Nijmegen, Radboud Hospital M318, P.O. Box 9101, NL-6500 HB, Nijmegen, The Netherlands

    H. G. Brunner, M. Coerwinkel-Driessen, H. Smeets, H. M. M. Lambermon, B. A. van Oost, B. Wieringa & H. -H. Ropers

  2. Genetics Division, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada

    R. G. Korneluk & A. MacKenzie

Authors
  1. H. G. Brunner
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  2. R. G. Korneluk
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  3. M. Coerwinkel-Driessen
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  4. A. MacKenzie
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  5. H. Smeets
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  6. H. M. M. Lambermon
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  7. B. A. van Oost
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  8. B. Wieringa
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  9. H. -H. Ropers
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Brunner, H.G., Korneluk, R.G., Coerwinkel-Driessen, M. et al. Myotonic dystrophy is closely linked to the gene for muscle-type creatine kinase (CKMM). Hum Genet 81, 308–310 (1989). https://doi.org/10.1007/BF00283680

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  • DOI: https://doi.org/10.1007/BF00283680

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