Abstract
Improved techniques in esophageal manometry have made this test an attractive option for investigating pharyngeal or esophageal disorders in patients with dysphagia. We studied esophageal as well as upper esophageal sphincter/pharyngeal (UES/P) pressure dynamics in 11 patients with an established diagnosis of oculopharyngeal muscular dystrophy with modern solidstate manometric techniques and then compared manometric and clinical findings. Esophageal manometric abnormalities were found in 10/11 patients, with the most common being simultaneous contractions and incomplete lower esophageal relaxation. 9/11 patients showed abnormal UES/P manometrics, with the most common abnormalities found in the pharynx. The presence of manometric abnormalities closely paralleled clinical assessment of degree of disease severity. Modern manometric techniques offer an opportunity for a quantitative assessment of swallow abnormalities.
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References
Taylor EW: Progressive vagus-glossopharyngeal paralysis with ptosis: a contribution to the group of family diseases. J Nerv Ment Dis 42:129, 1915
Victor M, Hayes R, Adams RD: Oculopharyngeal muscular dystrophy. A familial disease of late life characterized by dysphagia and progressive ptosis of the eyelids. N Engl J Med 267:1267, 1962
Myrianthopoulos NC, Brown IA: A genetic study of progressive spinal muscular atrophy. Am J Hum Genet 6:387, 1954
Weitzner S: Changes in the pharyngeal and esophageal musculature in oculopharyngeal muscular dystrophy. Am J Dig Dis 14:805, 1969
Duranceau AC, Beauchamp G, Jamieson GG, Barbeau A: Oropharyngeal dysphagia and oculopharyngeal muscular dystrophy. Surg Clin N Am 63:825, 1983
Hurwitz AL, Nelson JA, Haddad JK: Oropharyngeal dysphagia: manometric and cine esophagographic findings. Dig Dis 20:313–324, 1975
Binder MD: Esophageal manometry in oculopharyngeal dystrophy. Am J Gastroenterol 65:215–221, 1976
Fredet G, Pouliot D, Lavoie S, St-Pierre S: Inferior constrictor myotomy in oculopharyngeal muscular dystrophy: clinical and manometric evaluation. J Otolaryngol 17:68–73, 1988
Castell JA, Dalton CB, Castell DO: Pharyngeal and upper esophageal sphincter manometry in humans. Am J Physiol 258:G173-G178, 1990
Kharilas PJ, Dodds WJ, Dent J, Logemann J, Shaker R: Upper esophageal sphincter function during deglutition. Gastroenterology 95:52–62, 1988
Castell JA, Dalton CB, Castell DO: Effects of body position and bolus consistency on the manometric parameters and coordination of the upper esophageal sphincter and pharynx. Dysphagia 5:179–186, 1990
Sears VW, Castell JA, Castell DO: Radial and longitudinal asymmetry of the human pharynx. Gastroenterology 101: 1559–1563, 1991
Dudnick RS, Castell JA, Castell DO: Abnormal upper esophageal sphincter function in achalasia. Am J Gastroenterol 87:1712–1715, 1992
Benjamin SB, Elsold J, Gerhardt DC, Castell DO: Central nervous system lymphoma presenting as dysphagia. Dig Dis Sci 27:155–160, 1982
Taillefer R, Duranceau AC: Manometric and radionuclide assessment of pharyngeal emptying before and after cricopharyngeal myotomy in patients with oculopharyngeal muscular dystrophy. J Thorac Cardiovasc Surg 95:868–875, 1988
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Castell, J.A., Castell, D.O., Duranceau, C.A. et al. Manometric characteristics of the pharynx, upper esophageal sphincter, esophagus, and lower esophageal sphincter in patients with oculopharyngeal muscular dystrophy. Dysphagia 10, 22–26 (1995). https://doi.org/10.1007/BF00261275
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DOI: https://doi.org/10.1007/BF00261275