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The disposition of cyclophosphamide in a group of myeloma patients

  • Original Articles
  • Disposition of Cyclophosphamide in Myeloma
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Summary

The disposition of cyclophosphamide and its alkylating metabolites was investigated in a group of myeloma patients with varying degrees of renal function impairment. No correlation between renal function and clearance of cyclophosphamide or its alkylating metabolites was found. No evidence of accumulation of cyclophosphamide or alkylating activity was found in four patients receiving radiolabelled cyclophosphamide. Renal function was found to be related to the reciprocal of the area under curve of alkylating activity, indicating that this area increased as renal function decreased. In view of the large nonrenal component of alkylating activity elimination and the large inter-subject variability, it is recommended that dose of cyclophosphamide is not altered in moderate impairment of renal function.

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Author notes

  1. G. Edwards

    Present address: Department of Pharmacology and Therapeutics, The University, Liverpool, England

Authors and Affiliations

  1. Department of Medical Oncology, Christie Hospital, Withington, Manchester, England

    Vivien Bramwell, H. Scarffe & D. Crowther

  2. Holt Radium Institute, Withington, Manchester, England

    Vivien Bramwell, H. Scarffe & D. Crowther

  3. Pharmacy Department, Leeds General Infirmary, Leeds, England

    R. T. Calvert

  4. Pharmacy Department, University of Manchester, M13 9PL, Manchester, England

    G. Edwards

Authors
  1. Vivien Bramwell
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  2. R. T. Calvert
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  3. G. Edwards
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  4. H. Scarffe
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  5. D. Crowther
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Bramwell, V., Calvert, R.T., Edwards, G. et al. The disposition of cyclophosphamide in a group of myeloma patients. Cancer Chemother. Pharmacol. 3, 253–259 (1979). https://doi.org/10.1007/BF00254741

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  • DOI: https://doi.org/10.1007/BF00254741

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