Abstract
Quantitative hepatic scintiangiography was previously used for evaluating the relative contribution of hepatic arterial and portal venous blood flows to the hepatic circulation. The present study compares 3 different procedures (automatic and manual integration, and slope fitting methods) for analyzing the hepatic time activity curves obtained after bolus i.v. injection of 370 MBq 99mTc-diethylentriaminopentacetic acid. Twenty five subjects were studied: five controls, ten cirrhotics, and ten portal hypertensive patients previously submitted to side to side portacaval anastomosis. The correspondence between results given by the different methods was satisfactory only in shunted patients, and the reproducibility of computed parameters was quite poor for all procedures. Accordingly, none of the methods can be considered as supporting reliable quantitative pathophysiological evaluations. However, the hepatic arterial/portal venous flow ratio was found to be increased in liver cirrhosis and in shunted patients and therefore, in spite of the limitations underlined before and of the absence of data on the reproducibility of consecutive injections, hepatic scintiangiography may be of some clinical utility.
Similar content being viewed by others
References
Ackerman NB, Lien WM, Kondi ES, Silvermann NA (1969) The blood supply of experimental liver metastases. I. The distribution of hepatic artery and portal vein blood to “small” and “large” tumors. Surgery 66:1067–1073
Biersack HJ, Thelen M, Schultz R, Knop R, Dahlem R, Schmidt R, Winkler C (1977) Die sequentielle hepatospleno-szintigraphie zur quantitativen Beurteilung der Leberdurchblutung. Fortschr Rõngenstr 126:47–52
Biersack HJ, Torres J, Thelen M, Monzon O, Winkler C (1981) Determination of liver and spleen perfusion by quantitative sequential scintigraphy: results in normal subjects and in patients with portal hypertension. Clin Nucl Med 5:218–220
Boyd RO, Stadalnik RC, Barnett CA, Hines HH (1978) Quantitative hepatic scintiangiography. Clin Nucl Med 3:478–484
Breedis C, Young G (1954) The blood supply of neoplasm in the liver. Am J Pathol 30:696–701
Child III CG, Turcotte JG (1964) Surgery and portal hypertension. In: Child III CG (ed) The liver and portal hypertension. Saunders, Philadelphia, PA pp 1–85
Fleming JS, Ackery DM, Walmsley BH, Karran SJ (1983) Scintigraphic estimation of arterial and portal blood supplies to the liver. J Nucl Med 24:1108–1113
Richardson PDI, Withrington PC (1981) Liver blood flow. I. Intrinsic and nervous control of liver blood flow. Gastroenterology 81:159–173
Sachs L (1974) Angevandte Statistik (4th Ed). Springer, Berlin Heidelberg New York
Sarper R, Fajman WA, Rypins EB, Henderson JM, Tarkan YA, Galambos JT, Warren WD (1981) A noninvasive method for measuring portal venous total hepatic blood flow by hepatosplenic radionuclide angiography. Radiology 141:179–184
Siegel S (1956) Nonparametric statistics for the behavioural sciences. Mc Graw-Hill, New York
Stadalnik RC, De Nardo SJ, De Nardo CL, Raventos A (1975) Critical evaluation of hepatic scintangiography for neoplastic tumors of the liver. J Nucl Med 16:595–601
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gianpaolo, M., Massimo, B., Enzo, S. et al. Assessment of liver circulation by quantitative scintiangiography: evaluation of the relative contribution of the hepatic arterial and portal venous blood flows to liver perfusion. Eur J Nucl Med 15, 211–216 (1989). https://doi.org/10.1007/BF00253798
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00253798