Summary
To elucidate the pathogenesis of early ventricular dilatation in hydrocephalus, we examined early morphological changes in ependymal layers at the lateral ventricles in suckling hamsters without aqueductal stenosis 5 days after the intracerebral inoculation of mumps virus. Mumps virus antigen was detectable in all ependymal cells. The ependymal cilia had almost disappeared and only the microvilli remained. A number of supra-ependymal cells were also observed on the surface of the lateral ventricles. Transmission electron microscopy revealed intracytoplasmic viral-like inclusions in the infected ependymal cells. These results suggest that functional and morphological disturbances in infected ependymal cells may cause early ventricular dilatation before aqueductal stenosis occurs.
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Supported by a Grant-in-Aid from the Japanese Ministry of Health and Welfare for scientific research into “intractable hydrocephalus,-and by a Grant-in-Aid for scientific research from the Ministry of Education, Japan (C.No. 02670435)
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Takano, T., Mekata, Y., Yamano, T. et al. Early ependymal changes in experimental hydrocephalus after mumps virus inoculation in hamsters. Acta Neuropathol 85, 521–525 (1993). https://doi.org/10.1007/BF00230492
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DOI: https://doi.org/10.1007/BF00230492