Summary
A comparative study has been carried out on the micro-localization of catalase in mouse tissues subsequent to treatment with a representative range of hypolipidemic drugs.
A commonality of effect was shown by clofibrate (ethyl-α-p-chlorophenoxyisobutyrate), Wy-14,643 (4-chloro-6-[2,3 xylidino)-2-pyrimidinylthio] acetic acid), RMI-15,414 (5-tetradecyloxy-2-furancarboxylic acid) and aspirin (acetyl salicylic acid), in that treatments with each of these drugs was associated with the release of peroxisomal catalase into the cytoplasmic compartment of liver and kidney. It was also noticeable that this increased cytosolic activity was characterized by the presence of an ‘aged’ form of the enzyme with different mobility and activity characteristics to that of the peroxisomal enzyme.
Possible molecular bases for these effects and their relationship to peroxisomal biogenesis are discussed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Masters CJ, Holmes RS: Physiol Rev 57:816–882, 1977.
De Duve C: Ann NY Acad Sci 386:1–4, 1982.
Holmes RS, Masters CJ: Int J Biochem 1:474–482, 1970.
Holmes RS, Masters CJ: Arch Biochem Biophys 148: 217–223, 1972.
Reels F: J Histochem Cytochem 24:713–724, 1976.
Reels R, Geerts A, De Coster W, Goldfischer S: Ann NY Acad Sci 386:534–539, 1982.
Krishnakantha TP, Moody DE, Reddy JK: Fed Proc 34:825, 1975.
Beers RF, Sizer IW: J Biol Chem 195:133–140, 1952.
Kalkar HM: J Biol Chem 167:429–443, 1947.
Reddy JK, Warren JR, Reddy MK, Lalwani ND: Ann NY Acad Sci 386:81–108, 1982.
Platt DS, Thorp JM: Biochem Pharmacol 15:915–925, 1966.
Böck P, Kramar R, Pavelka M: Peroxisomes and Related Particles. Springer-Verlag, Wien, New York, 1980.
Riede UN, Rohr HP: Beitr Pathol 151:111–133, 1974.
Leighton F, Colma L, Koenig C: J Cell Biol 67:281–309, 1975.
Hess R, Staubli W, Riess W: Nature 208:856–858, 1965.
Appelkvist EL, Brunk U, Dallner G: J Biochem Biophys Meth 5:203–217, 1981.
Svoboda DJ, Azarnoff DL: J Cell Biol 30:442–449, 1966.
Reddy JK, Bunyaratyej S, Svoboda DJ: J Cell Biol 42:587–594, 1969.
Legg PG, Wood RL: J Cell Biol 45:118–125, 1970.
Parthasarathy S, Kritchevsky D, Baumann WJ: Proc Natl Acad Sci USA 79:6890–6893, 1982.
Donaldson RP, Tolbert NE, Schnarrenberger C: Arch Biochem Biophys 152:199–215, 1972.
Crane D, Holmes R, Masters CJ: Biochim Biophys Acta 712:57–64, 1982.
Fujiki Y, Fowler S, Shio H, Hubbard AL, Lazarow PB: J Cell Biol 93:103–110, 1982.
Flatmark T, Christiansen EN, Kryui H: Eur J Cell Biol 24:62–69, 1981.
Masters CJ: Ann NY Acad Sci 386:301–313, 1982.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Klucis, E., Crane, D. & Masters, C. Sequential alterations in the micro-localization of catalase in mouse liver after treatment with hypolipidemic drugs. Mol Cell Biochem 65, 73–82 (1984). https://doi.org/10.1007/BF00226021
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00226021