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Acquired protein S deficiency

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Summary

Hereditary deficiencies of coagulation inhibitors like antithrombin 111, protein C and protein S lead to an enhanced incidence of thromboembolic complications. Recently, acquired deficiencies of protein S were described in several disease states in which thromboembolic complications frequently occur. These acquired protein S deficiencies reach — in part — the extent realised by hereditary protein S deficiency. Thus, acquired protein S deficiencies seem to be one source of thromboembolic complications occurring in nephrotic syndrome, acute phase reactions, malignancy and pregnancy. In this presentation disease states accompanied by acquired protein S deficiency and the mechanisms leading to these alterations are discussed.

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Abbreviations

AT III:

antithrombin III

C4b-BP:

C4b-binding protein

DIC:

disseminated intravascular coagulation

SLE:

systemic lupus erythematosus

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  1. Zentrum für Innere Medizin der Justus Liebig Universität Gießen, Klinikstrasse 36, W-6300, Gießen

    B. Kemkes-Matthes

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Kemkes-Matthes, B. Acquired protein S deficiency. Clin Investig 70, 529–534 (1992). https://doi.org/10.1007/BF00210237

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