Abstract
Three patients developed cerebral gliomas decades after exposure to low-dose x-ray irradiation in childhood for the treatment of tinea capitis. One of the patients had a glioblastoma multiforme concomitant with multiple intracranial meningiomas, a condition highly correlated with previous irradiation. The other tumors were malignant cerebellar astrocytoma and a diffuse cerebral astrocytoma. We review the evidence suggesting that low-dose irradiation is involved in the pathogenesis of gliomas.
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Adamson HG: A simplified method of x-ray application for the cure of ringworm of the scalp: Kienbock's method. Lancet 1: 1378–1380, 1909
Cipollaro AC, Kallos A, Ruppe Jr JP: Measurement of gonadal radiations during treatment for tinea capitis. NY State J Med 59: 3033–3040, 1959
Modan B, Baidatz D, Mart H, Steinitz R, Levin SG: Radiation-induced head and neck tumours. Lancet 1: 277–279, 1974
Schulz RJ, Albert RE: Follow-up study of patients treated by x-ray epilation for tinea capitis. III. Dose to organs of the head from the x-ray treatment of tinea capitis. Arch Environ Health 17: 935–950, 1968
Werner E, Modan B, Davidoff D: Doses to the brain, skull and thyroid following x-ray treatment of tinea capitis. Phys Med Biol 13: 247–258, 1968
Munk J, Peyser E, Gruszkiewicz J: Radiation induced intracranial meningiomas. Clin Radiol 120: 90–94, 1969
Beller AJ, Feinsod M, Sahar A: The possible relationship between small dose irradiation to the scalp and intracranial meningiomas. Neurochir (Stutt.) 15: 135–143, 1972
Soffer D, Pittaluga S, Feiner M, Beller AJ: Intracranial meningiomas following low-dose irradiation to the head. J Neurosurg 59: 1048–1053, 1983
Rubinstein AB, Shalit MN, Cohen ML, Zandbank U: Radiation-induced cerebral meningioma: a recognizable entity. J Neurosurg 61: 966–971, 1984
Shore RE, Albert RE, Pasternack BS: Follow-up study of patients treated by x-ray epilation for tinea capitis. Arch Environ Health 31: 17–24, 1976
Ron E, Modan B, Boice Jr JD, Alfandary E, Stovall M, Chetrit A, Katz L: Tumors of the brain and nervous system after radiotherapy in childhood. N Eng J Med 319: 1033–1039, 1988
Saenger EL, Silverman IN, Sterling TD, Turner ME: Neoplasia following therapeutic irradiation for benign conditions in childhood. Radiology 74: 889–904, 1960
Mole RH: Late effects of radiation: carcinogenesis. Br Med Bull 29: 78–83, 1973
Clifton MD, Amromin GD, Perry MC, Abadir R, Watts C, Levy N: Spinal cord glioma following irradiation for Hodgkin's disease. Cancer 45: 2051–2055, 1980
Soffer D, Gomori JM, Siegal T, Shalit MN: Intracranial meningiomas following high-dose irradiation. Report of 3 cases and review of the literature. Cancer (In press)
Iacono RP, Apuzzo MLJ, Davis RL, Tsai FY: Multiple meningiomas following radiation therapy for medulloblastoma. Case report. J Neurosurg 55: 282–286, 1981
Liwnicz BH, Berger TS, Liwnicz BS, Aron BS: Radiation-associated glioblastomas: a report of four cases and analysis of postradiation tumors of the central nervous system. Neurosurgery 17: 436–445, 1985
Marus G, Levin V, Rutherfoord GS: Malignant glioma following radiotherapy for unrelated primary tumors. Cancer 58: 886–894, 1986
Russell DS, Rubinstein LJ: Astrocytomas of the cerebellum. In: Pathology of Tumours of the Nervous System. 4th edition, E. Arnold, London pp. 183–190, 1977
Kopelson G: Cerebellar glioblastoma. Cancer 50: 308–311, 1982
Zulch KJ: Astrocytic tumors. In: Brain Tumors. Their Biology and Pathology. 3rd Edition, Springer-Verlag, Berlin, pp. 210–240, 1986
Rimm IJ, Li FC, Tarbell NJ et al.: Brain tumors after cranial irradiation for childhood acute lymphoblastic leukemia. Cancer 59: 1506–1508, 1987
Zochodne DW, Cairncross JG, Arce FP, MacDonald JCF, Blume WT, Girvin JP, Kaufmann JCE: Astrocytoma following scalp radiotherapy in infancy. Can J Neurol Sci 11: 475, 1984
Albo V, Miller D, Leiken S, Sather H, Hammond D: Nine brain tumors as a late effect in children ‘cured’ of acute lymphoblastic leukemia (Abstr). Proc Am Soc Clin Oncol 4: 172, 1985
Kent SP, Pickering JE: Neoplasms in monkeys (Macaca mullata): spontaneous and irradiation induced. Cancer 11: 138–147, 1985
Haymaker W, Rubinstein LJ, Miguel J: Brain tumors in irradiated monkeys. Acta Neuropathol 20: 267–277, 1972
Krupp JH: Nine year mortality experience in proton-exposed Macaca mulatta. Radiat Res 67: 244–257, 1976
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Soffer, D., Moshe Gomori, J., Pomeranz, S. et al. Gliomas following low-dose irradiation to the head report of three cases. J Neuro-Oncol 8, 67–72 (1990). https://doi.org/10.1007/BF00182089
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DOI: https://doi.org/10.1007/BF00182089