Summary
Toxoplasmosis may cause serious problems after organ transplantation. For treatment of active infection, pyrimethamine combined with a sulfonamide is recommended. During oral sulfadiazine therapy, a significant decrease in cyclosporine concentrations was observed in three heart transplant recipients. This interaction has not been reported previously.
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Spes, C.H., Angermann, C.E., Stempfle, H.U. et al. Sulfadiazine therapy for toxoplasmosis in heart transplant recipients decreases cyclosporine concentration. Clin Investig 70, 752–754 (1992). https://doi.org/10.1007/BF00180742
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DOI: https://doi.org/10.1007/BF00180742