Abstract
The effects of the 5-hydroxytryptamine (5-HT) uptake inhibitor clomipramine on the prolactin (PRL) and growth hormone (GH) responses to l-tryptophan (LTP) were assessed in six normal subjects. Oral administration of 20 mg clomipramine 2 h prior to LTP infusion (50 mg/kg) significantly enhanced both endocrine responses, suggesting that the increases in plasma PRL and GH produced by LTP are mediated by 5-HT pathways. These findings, taken together with previous observations that 5-HT2 receptor antagonists do not attenuate the PRL response to LTP, suggest that the 5-HT-induced release of PRL in man may be mediated by 5-HT1 receptors.
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References
Charney DS, Heninger GR, Renhard JF, Sternberg DE, Hafstead KM (1982) Effect of intravenous l-tryptophan on prolactin and growth hormone and mood in healthy subjects. Psychopharmacology 77:217–222
Charney DS, Heninger GR, Sternberg DE (1984) Serotonin function and mechanism of action of antidepressant treatment: effect of amitriptyline and desipramine. Arch Gen Psychiatry 41:359–365
Checkley SA (1980) Neuroendocrine tests of monoamine function in man: a review of basic theory and its application to the study of depressive illness. Psychol Med 10:35–53
Cowen PJ, Gadhvi H, Gosden B, Kolakowska T (1985) Responses of prolactin and growth hormone to l-tryptophan infusion: effects in normal subjects and schizophrenic patients receiving neuroleptics. Psychopharmacology 86:164–169
Cowen PJ, Anderson IM (1986) 5-HT neuroendocrinology: changes during depressive illness and antidepressant drug treatment. In: Deakin JFW, Freeman H (eds) Recent advances in the biology of depression. Royal College of Psychiatrists, special publication
Hall H, Ogren SO (1981) Effects of antidepressant drugs on different receptors in the brain. Eur J Pharmacol 70:393–407
Jones RL, Luscombe DK (1976) Plasma levels of clomipramine and its N-desmethyl metabolite following oral clomipramine in man. Br J Pharmacol 57:430P
Knopf RF, Lunn JW, Fagans SS, Floyd JL, Guntsche EM, Rull JA (1965) Plasma growth hormone response to intravenous administration of amino acids. J Clin Endocrinol Metab 25:1140–1144
Laakman G, Schumacher G, Benkert O, v Wender K (1977) Stimulation of growth hormone secretion by desimipramine and chlorimipramine in man. J Clin Endocrinol Metab 44:1010–1013
Laakman G, Gugath M, Kuss H-J, Zygan K (1984) Comparison of growth hormone and prolactin stimulation induced by chlorimipramine and desimipramine in man in connection with chlorimipramine metabolism. Psychopharmacology 82:62–67
Leysen JE, Awouters F, Kennis L, Laduron PM, Vanderberk J, Janssen PAJ (1981) Receptor binding profile of R 41468, a novel antagonist at 5-HT2 receptors. Life Sci 28:1115–1122
Meltzer HY, Simonovic RD, Sturgeon RD, Fang US (1981) Effect of antidepressants, lithium and electroconvulsive shock on rat serum prolactin levels. Acta Psychiatr Scand 63 (Suppl 290):100–121
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Anderson, I.M., Cowen, P.J. Clomipramine enhances prolactin and growth hormone responses to l-tryptophan. Psychopharmacology 89, 131–133 (1986). https://doi.org/10.1007/BF00175205
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DOI: https://doi.org/10.1007/BF00175205