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Effect of lonidamine on human malignant gliomas: Biochemical studies

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Summary

Lonidamine (LND) has been shown to inhibit tumor aerobic glycolysis. Its effect was evaluated on several human astrocytomas at different degrees of malignancy; a correlation was found between LDN effect on lactate production and tumor malignancy: in grade I and II astrocytomas LND stimulates lactate production, while in grade III, IV and glioblastoma multiforme lactate production is inhibited.

In an attempt to explain this different behaviour, hexokinase content and compartmentation was evaluated in astrocytomas from fresh operatory specimens and from cultured cells as well, observing a significative correlation between malignancy, hexokinase activity, percent of mitochondrially-bound hexokinase and LND effect.

The results justify from a biochemical point of view the role of LND as a ‘non-conventional’ agent in multimodality combined treatment for malignant gliomas.

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Authors and Affiliations

  1. ‘Regina Elena’ Institute for Cancer Research, Viale Regina Elena, 291, 00161, Roma, Italy

    Marco G. Paggi, Carmine M. Carapella, Maurizio Fanciulli, Carlo Del Carlo, Sergio Giorno, Gabriella Zupi, Antonio Caputo & Aristide Floridi

  2. Institute of Pharmacology and Pharmacognosy, University of Rome ‘La Sapienza’, Rome, Italy

    Bruno Silvestrini

Authors
  1. Marco G. Paggi
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  2. Carmine M. Carapella
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  3. Maurizio Fanciulli
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  4. Carlo Del Carlo
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  5. Sergio Giorno
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  6. Gabriella Zupi
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  7. Bruno Silvestrini
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  8. Antonio Caputo
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  9. Aristide Floridi
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Additional information

Work performed as part of CNR Research Project ‘Oncologia’, grant n. 86.00662.44 and partially supported by Associazione Italiana Ricerca sul Cancro, grant AIRC/86.

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Paggi, M.G., Carapella, C.M., Fanciulli, M. et al. Effect of lonidamine on human malignant gliomas: Biochemical studies. J Neuro-Oncol 6, 203–209 (1988). https://doi.org/10.1007/BF00163702

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