Synaptonemal complex aberrations can provide a sensitive measure of chemical-specific alterations to meiotic chromosomes. Mitomycin C, cyclophosphamide, amsacrine, ellipticine, colchicine, vinblastine sulfate, and cis platin exposures in mice have been shown to cause various patterns of synaptonemal complex structural damage and synaptic irregularity. These effects are suggestive of abnormal homologue pairinglsynapsis/recombination effects which, theoretically, could be implicated in mechanisms leading to aneuploidy and other potentially heritable chromosomal disorders.
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Abbreviations
- C:
-
colchicine
- cis-DDP:
-
cisplatin
- CP:
-
cyclophosphamide
- EL:
-
ellipticine
- i.p.:
-
intraperitoneal
- i.t.:
-
intratesticular
- m-AMSA:
-
amsacrine
- MC:
-
mitomycin C
- SC:
-
synaptonemal complex
- VS:
-
vinblastine sulfate
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This manuscript has been reviewed by the Health Effects Research Laboratory, U.S. Environmental Protection Agency, and approved for publication. Approval does not signify that the contents necessarily reflect the views and policies of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use.
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Allen, J.W., Poorman, P.A., Backer, L.C. et al. Synaptonemal complex damage as a measure of genotoxicity at meiosis. Cell Biol Toxicol 4, 487–493 (1988). https://doi.org/10.1007/BF00117776
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DOI: https://doi.org/10.1007/BF00117776