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Periostin and Integrin Signaling in Stem Cell Regulation

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Periostin

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1132))

Abstract

Stem cell function is regulated by a huge repertoire of external cues along with stem cell intrinsic genetic and epigenetic factors. These interactions come through a variety of cell adhesion receptors, of which integrins are one of the most important classes. They interact with extracellular matrix (ECM) components and various bound proteins. Apart from inside-out signaling through which integrins ensure that the cells are stably bound to the ECM, outside-in integrin signaling, through binding to a variety of ligands, play important roles in cell fate decisions. Periostin is one such ligand whose role in functional regulation of stem cells is emerging due to its wide expression profile. In this review, we discuss the recent advancements made in the field.

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Acknowledgements

This work was supported by the Wellcome Trust/DBT India Alliance Fellowship (IA/I/15/2/502061) awarded to SK and intramural funds from Indian Institute of Science Education and Research Thiruvananthapuram (IISER TVM). AS is supported by INSPIRE fellowship from Department of Science and Technology, Government of India Scientific and Industrial Research, India. AB is supported by IISER TVM.

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  1. Authors Athira Suresh, Atreyi Biswas and Saravana Perumal have been equally contributed for this chapter.

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  1. School of Biology, Indian Institute of Science Education and Research Thiruvananthapuram (IISER TVM), Thiruvananthapuram, Kerala, India

    Athira Suresh, Atreyi Biswas, Saravana Perumal & Satish Khurana

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  1. Athira Suresh
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  1. International Frontier, Tokyo Institute of Technology, Tokyo, Japan

    Akira Kudo

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Suresh, A., Biswas, A., Perumal, S., Khurana, S. (2019). Periostin and Integrin Signaling in Stem Cell Regulation. In: Kudo, A. (eds) Periostin. Advances in Experimental Medicine and Biology, vol 1132. Springer, Singapore. https://doi.org/10.1007/978-981-13-6657-4_16

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