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Gene-environment interactions in occupational asthma

  • Chapter
Occupational Asthma

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

This chapter reviews the existing knowledge regarding gene-environment interactions in occupational asthma. So far, studies have been conducted on relatively small samples, considering workers exposed to specific hazards such as isocyanates or red cedar. HLA class II, genes in the antioxidant defense, and more recently genes in the innate immunity pathway have been studied. As yet, few interactions have been demonstrated; however, the development of large-scale genetic studies of asthma will likely change the situation. Two types of approach can be developed based on testing hypotheses (candidate interactions) or in searching interactions with genes of yet-unknown function that may be evidenced through genome-wide associations. Current challenges concern the improvement of phenotypic and environmental characterization and setting up interdisciplinary research to understand the determinants of asthma. Building large international consortia on asthma with data on occupational exposure is warranted.

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Author information

Authors and Affiliations

  1. Inserm, U780 — Epidemiology and Biostatistics, Villejuif, France

    Francine Kauffmann, Lidwien A. M. Smit & Rachel Nadif

  2. Université Paris Sud, IFR69, Villejuif, France

    Francine Kauffmann, Lidwien A. M. Smit & Rachel Nadif

  3. Center for Research in Environmental Epidemiology (CREAL), Barcelona, Spain

    Francesc Castro-Giner & Manolis Kogevinas

  4. Municipal Institute of Medical Research, Barcelona, Spain

    Francesc Castro-Giner & Manolis Kogevinas

  5. CIBER Epidemiologia y Salud Publica (CIBERESP), Spain

    Francesc Castro-Giner & Manolis Kogevinas

  6. Medical School, University of Crete, Heraklion, Greece

    Manolis Kogevinas

Authors
  1. Francine Kauffmann
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  2. Francesc Castro-Giner
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  3. Lidwien A. M. Smit
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  4. Rachel Nadif
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  5. Manolis Kogevinas
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Editor information

Editors and Affiliations

  1. School of Public Health Dept. of Environmental and Occupational Medicine, Aarhus University, Bartholin Allé 2, 8000, Århus C, Denmark

    Torben Sigsgaard

  2. Institute for Risk Assessment Sciences Division of Environmental and Occupational Health, Utrecht University, Yalelaan 2, 3508 TD, Utrecht, Netherlands

    Dick Heederik

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Kauffmann, F., Castro-Giner, F., Smit, L.A.M., Nadif, R., Kogevinas, M. (2010). Gene-environment interactions in occupational asthma. In: Sigsgaard, T., Heederik, D. (eds) Occupational Asthma. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8556-9_12

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  • DOI: https://doi.org/10.1007/978-3-7643-8556-9_12

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-7643-8555-2

  • Online ISBN: 978-3-7643-8556-9

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