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Proliferation in Pituitary Adenomas: Measurement by MAb KI 67

  • Conference paper
Processes of the Cranial Midline

Part of the book series: Acta Neurochirurgica Supplementum ((NEUROCHIRURGICA,volume 53))

Summary

The monoclonal antibody MAb KI 67 reacts with a nuclear antigen throughout the entire cell cycle and allows easy evaluation of proliferating tumour cells on routinely prepared smear and frozen sections. 120 pituitary adenomas were investigated by use of the monoclonal antibody KI 67 in a two-step avidin-biotin-peroxidase complex (ABC) technique. The KI 67 labelling index (LI) ranged in all adenomas from 0.2 to 4.6%. In 90 cases of transphenoidally operated adenomas the dura of the sella floor was investigated histologically. Adenomas with histologically proven dural infiltration showed a statistically significant higher KI 67 LI (p < 0.001) compared to non-invasive adenomas.

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Authors and Affiliations

  1. Department of Neurosurgery, Vienna Medical School, Währinger Gürtel 18-20, A-1090, Wien, Austria

    K. Kitz M.D., E. Knosp, W. Th. Koos & A. Korn

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  1. K. Kitz M.D.
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  2. E. Knosp
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  3. W. Th. Koos
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  4. A. Korn
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Editor information

Editors and Affiliations

  1. Department of Neurosurgery, University of Vienna Medical School, Vienna, Austria

    Wolfgang Koos  & Bernd Richling  & 

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© 1991 Springer-Verlag

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Kitz, K., Knosp, E., Koos, W.T., Korn, A. (1991). Proliferation in Pituitary Adenomas: Measurement by MAb KI 67. In: Koos, W., Richling, B. (eds) Processes of the Cranial Midline. Acta Neurochirurgica Supplementum, vol 53. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9183-5_11

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  • DOI: https://doi.org/10.1007/978-3-7091-9183-5_11

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-9185-9

  • Online ISBN: 978-3-7091-9183-5

  • eBook Packages: Springer Book Archive

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