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Alveolar Epithelial Barrier: Acute Lung Injury

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Yearbook of Intensive Care and Emergency Medicine 2000

Part of the book series: Yearbook of Intensive Care and Emergency Medicine ((YEARBOOK,volume 2000))

Abstract

This chapter reviews new insights into the basic mechanisms that regulate vectorial transport of salt and water across the alveolar epithelium of the adult lung. The first section provides evidence that active ion (sodium) transport is the primary mechanism that regulates in vivo alveolar fluid clearance. This section includes a discussion of how catecholamine dependent and independent mechanisms can up-regulate alveolar fluid transport. The second section briefly discusses evidence that implicates transcellular water channels in alveolar epithelial fluid transport. The third section describes the transport function of the alveolar epithelial barrier under pathological conditions that are relevant to clinical pulmonary edema and the acute respiratory distress syndrome (ARDS). Some of this information has been reviewed recently [1].

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  1. M. A. Matthay
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  2. T. Nuckton
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  3. B. Daniel
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Editors and Affiliations

  1. Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Head Department of Intensive Care) (Head Department of Intensive Care)

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Matthay, M.A., Nuckton, T., Daniel, B. (2000). Alveolar Epithelial Barrier: Acute Lung Injury. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine 2000. Yearbook of Intensive Care and Emergency Medicine, vol 2000. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-13455-9_17

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