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The Ah Locus: Aromatic Hydrocarbon Responsiveness... of Mice and Men

1. The P-450-Mediated Monooxygenases

  • Conference paper
Human Genetic Variation in Response to Medical and Environmental Agents: Pharmacogenetics and Ecogenetics

Part of the book series: Human Genetics, Supplement ((HUMAN GENETICS,volume 1))

Abstract

The membrane-bound cytochrome P-450-mediated monooxygenases are known to metabolize numerous drugs, environmental pollutants, chemical carcinogens, other foreign compounds, and numerous endogenous substrates (Thorgeirsson and Nebert, 1977; Ullrich et al. , 1977). The monooxygenase system-depicted in the upper left of Figure 1 as the rectangle of flavoprotein reductases, phospholipid, and hemoproteins-is deeply embedded in the endoplasmic reticulum membrane and perhaps in other membranes of the cell. The various monooxygenase ‘activities’ rely on the integrity of electron transport between the flavoproteins and the hemoproteins.

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Authors and Affiliations

  1. National Institute of Child Health and Human Development, National Institutes of Health, Developmental Pharmacology Branch, Bethesda, Maryland, 20014, USA

    Daniel W. Nebert & Steven A. Atlas

Authors
  1. Daniel W. Nebert
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  2. Steven A. Atlas
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Editor information

Editors and Affiliations

  1. Institut für Anthropologie und Humangenetik, Universität Heidelberg, Im Neuenheimer Feld 328, D-6900, Heidelberg, Germany

    Friedrich Vogel , Werner Buselmaier  & Walter Reichert ,  & 

  2. Department of Human Oncology, University of Wisconsin, Madison, 53706, WI, USA

    Gottfried Kellermann

  3. Chirurgische Klinik, Im Neuenheimer Feld 110, D-6900, Heidelberg, Germany

    Peter Berg

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© 1978 Springer-Verlag Berlin Heidelberg

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Nebert, D.W., Atlas, S.A. (1978). The Ah Locus: Aromatic Hydrocarbon Responsiveness... of Mice and Men. In: Vogel, F., Buselmaier, W., Reichert, W., Kellermann, G., Berg, P. (eds) Human Genetic Variation in Response to Medical and Environmental Agents: Pharmacogenetics and Ecogenetics. Human Genetics, Supplement, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67179-1_20

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  • DOI: https://doi.org/10.1007/978-3-642-67179-1_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-09175-2

  • Online ISBN: 978-3-642-67179-1

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