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Approaches to Evaluating the Association of Vitamin D Receptor Gene Polymorphisms with Breast Cancer Risk

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Vitamin D Analogs in Cancer Prevention and Therapy

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 164))

Abstract

The steroid hormone 1,25 dihydroxyvitamin D3is thought to protect against breast cancer. Its actions are mediated via the vitamin D receptor (VDR) and a number of polymorphisms in the VDR gene have been identified, some of which may alter susceptibility to breast cancer. This study has investigated whether specific VDR gene polymorphisms are associated with breast cancer risk in a UK Caucasian population. Female breast cancer patients (n=313) and control women with a negative screening mammogram (n=410) were recruited and their VDR polymorphisms were determined. The 30 VDR polymorphism BsmI was significantly associated with breast cancer risk; odds ratio bb vs. BB genotype =1.79 (95% CI, 1.12–C2.86; P=0.0221). In addition, over 70% of seven commonly used breast cancer cell lines were found to have the at-risk genotype bb. The 50 FokI gene variant was not associated with breast cancer risk. Further investigations into how these different genotypes may affect the functional mechanisms of the VDR will provide a better strategy for identifying women at risk of breast cancer and for developing improved treatments.

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Authors and Affiliations

  1. Department of Cellular and Molecular Medicine, St. George’s Hospital Medical School, Cranmer Terrace, London, SW17 ORE, UK

    Michelle Guy, Lorraine C. Lowe, Deborah Bretherton-Watt, Janine L. Mansi & Kay W. Colston

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  1. Michelle Guy
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  2. Lorraine C. Lowe
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  3. Deborah Bretherton-Watt
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  4. Janine L. Mansi
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  5. Kay W. Colston
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Editors and Affiliations

  1. Hautklinik und Poliklinik der Universitätskliniken des Saarlandes, Kirrberger Str., 66421, Homburg/Saar

    Jörg Reichrath  & Wolfgang Tilgen  & 

  2. Frauenklinik des Universitätsklinikums der Eberhard-Karls-Universität, Calwerstr. 7, 71076, Tübingen

    Michael Friedrich

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© 2003 Springer-Verlag Berlin Heidelberg

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Guy, M., Lowe, L.C., Bretherton-Watt, D., Mansi, J.L., Colston, K.W. (2003). Approaches to Evaluating the Association of Vitamin D Receptor Gene Polymorphisms with Breast Cancer Risk. In: Reichrath, J., Tilgen, W., Friedrich, M. (eds) Vitamin D Analogs in Cancer Prevention and Therapy. Recent Results in Cancer Research, vol 164. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55580-0_3

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  • DOI: https://doi.org/10.1007/978-3-642-55580-0_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62435-3

  • Online ISBN: 978-3-642-55580-0

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