Synonyms
Definition
Adjuvant-induced arthritis is a model of chronic immune-mediated joint inflammation that is induced by injection, usually sub- or intradermally, of a suspension of heat killed Mycobacterium tuberculosis (Mycobacterium Species) in oil (Freund’s Complete Adjuvant or FCA).
Characteristics
The classical model of adjuvant-induced polyarthritis is induced in rats, using an intradermal injection of mycobacterium tuberculosis suspension in paraffin oil at the tail base. The reaction to adjuvant injection is generally one of systemic illness, with inflammation affecting tarsal, carpal, phalangeal, and spinal joints after 11–16 days (Pearson and Wood 1959). Arthritis is accompanied by lesions of the eyes, ears, nose, skin, and genitals, in addition to anorexia and profound weight loss. The disease follows a relapsing-remitting course after the initial 2 weeks and may persist for several months (Pearson and Wood 1959).
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References
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Chillingworth, N.L., Donaldson, L.F. (2013). Arthritis Model, Adjuvant-Induced Arthritis. In: Gebhart, G.F., Schmidt, R.F. (eds) Encyclopedia of Pain. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-28753-4_282
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