Abstract
Hippocampal atrophy and developmental positional variants may co-occur in various neurological disorders. We propose a surface-based framework to analyze independently volume and positioning. After extracting the spherical harmonics combined with point distribution models (SPHARM-PDM) from manual labels, we computed displacement vectors between individual surfaces and the template. Then, we computed surface-based Jacobian determinants (SJD) from these vectors to localize volume changes. To analyze positional variants, we constructed a mean meridian axis (MEMAX), inheriting the shape-constrained point correspondences of SPHARM, on which we compute local curvatures and position vectors. We validated our method on synthetic shapes, and a large database of healthy subjects and patients with temporal lobe epilepsy. Our comprehensive analysis showed that in patients atrophy and positional changes co-occurred at the level of the posterior hippocampus. Indeed, in this region, while SPHARM-PDM showed mirrored deformations, SJD detected atrophy, and shape analysis of MEMAX unveiled medial positioning due to bending.
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Kim, H., Mansi, T., Bernasconi, A., Bernasconi, N. (2011). Vertex-Wise Shape Analysis of the Hippocampus: Disentangling Positional Differences from Volume Changes. In: Fichtinger, G., Martel, A., Peters, T. (eds) Medical Image Computing and Computer-Assisted Intervention – MICCAI 2011. MICCAI 2011. Lecture Notes in Computer Science, vol 6892. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-23629-7_43
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DOI: https://doi.org/10.1007/978-3-642-23629-7_43
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