Abstract
Forensic neuropathology has established itself as an independent discipline within forensic science. More specific information can be found by referring to the relevant literature (e.g., Leestma 2009; Oehmichen et al. 2006; Itabashi et al. 2007; Chan and Lowe 2002; Oehmichen and König 1997; Bratzke and Krauland 1988; Bratzke et al. 1986; Krauland 1973, 1981, 1982).
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References
Abu AL, Ragheb SY, Koussous KJ, Amr SS (1986) Intracranial neoplasms associated with sudden death: a report of seven cases and a review of the literature. Med Sci Law 26:270–272
Althoff H (1982) Zur Ätiologie und Pathogenese des Waterhouse-Friderichsen-Syndroms. Z Rechtsmed 88:173–184
American Academy of Pediatrics (2001) Shaken baby syndrome: rotational cranial injuries – technical report. Pediatrics 108:206–210
Amine ARC (1997) Neurosurgical complications of heroin addiction: brain abscess and mycotic aneurysm. Surg Neurol 7:385–386
Andersen SN, Skullerud K (1999) Hypoxic/ischaemic brain damage, especially pallidal lesions, in heroin addicts. Forensic Sci Int 102:51–59
Andrade DM, Ackerley CA, Minett TS, Teive HA, Bohlega S, Scherer SW, Minassian BA (2003) Skin biopsy in Lafora disease: genotype-phenotype correlations and diagnostic pitfalls. Neurology 61:1611–1614
Arlotti SA, Forbes BJ, Dias MS, Bonsall DJ (2007) Unilateral retinal hemorrhages in shaken baby syndrome. J AAPOS 11:175–178
Balko MG, Schultz DL (1999) Sudden death due to a central neurocytoma. Am J Forensic Med Pathol 20:180–183
Bauer M, Lang C, Patzelt D (2001) Sudden death due to pituitary apoplexy. Leg Med 3:183–186
Baum JD, Bulpitt CJ (1970) Retinal and conjunctival haemorrhage in the newborn. Arch Dis Child 45:344–349
Betz P, Püschel K, Miltner E, Lignitz E, Eisenmenger W (1996) Morphometrical analysis of retinal hemorrhages in the shaken baby syndrome. Forensic Sci Int 78:71–80
Black M, Graham DI (2002) Sudden unexplained death in adults caused by intracranial pathology. J Clin Pathol 55:44–50
Böhm N (1982) Adrenal, cutaneous and myocardial lesions in fulminating endotoxinemia (Waterhouse-Friderichsen syndrome). Pathol Res Pract 174:92–105
Bowen DA (1984) Ruptured berry aneurysms: a clinical, pathological and forensic review. Forensic Sci Int 26:227–234
Bratzke H, Eisenmenger W (1989) Traumatische Ruptur der Arteria communicans anterior. Beitr Gerichtl Med XLVII:437–440
Bratzke H, Krauland W (1988) Zur Genese und Morphologie des traumatischen Mediainfarktes (Fallbericht). In: Bauer G (ed) Gerichtsmedizin – Festschrift für Wilhelm Holczabek. Deutike-Verlag, Wien
Bratzke H, Püschel K, Colmant HJ (1986) The phenomena and morphology for fatal aneurysms causing brain hemorrhage. Z Rechtsmed 96:245–273
Buschmann CT, Matejic D, Semm K, Tsokos M (2008) Lhermitte-Duclos syndrome as the cause of sudden death. Rechtsmedizin 19:34–36
Büttner A, Weis S (2004) Central nervous system alterations in drug abuse. In: Tsokos M (ed) Forensic pathology reviews, vol I. Humana Press, Totowa, pp 79–136
Büttner A, Winkler PA, Eisenmenger W, Weis S (1997) Colloid cysts of the third ventricle with fatal outcome: a report of two cases and review of the literature. Int J Legal Med 110:260–266
Büttner A, Gall C, Mall C, Weis S (1999) Unexpected death in persons with symptomatic epilepsy due to glial brain tumors: a report of two cases and review of the literature. Forensic Sci Int 100:127–136
Büttner A, Mall G, Penning R, Weis S (2000) The neuropathology of heroin abuse. Forensic Sci Int 113:435–442
Büttner A, Weis S, Mall G, Gall C, Eisenmenger W (2001) The diagnostic relevance of cerebral amyloid angiopathy in the setting of forensic pathology – a report of two cases and review of the literature. Leg Med 3:141–148
Büttner A, Rohrmoser K, Mall G, Penning R, Weis S (2006) Widespread axonal damage in the brain of drug abusers as evidenced by accumulation of beta-amyloid precursor protein (beta-APP): an immunohistochemical investigation. Addiction 101:1339–1346
Byard RW (2004) Neurologic conditions. In: Sudden death in infancy, childhood and adolescence, 2nd edn. Cambridge University Press, Cambridge, pp 366–372, Chapter 8
Byard RW, Bourne AJ, Hanieh A (1991) Sudden and unexpected death due to hemorrhage from occult central nervous system lesions. A pediatric autopsy study. Pediatr Neurosurg 17:88–94
Caffey J (1972) On the theory and practice of shaking infants. Its potential residual effects of permanent brain damage and mental retardation. Am J Dis Child 124:161–169
Caparros-Lefebvre D, Policard J, Sengler C, Benabdallah E, Colombani S, Rigal M (2005) Bipallidal haemorrhage after ethylene glycol intoxication. Neuroradiology 47:105–107
Centers for Disease Controal – CDC (1997) Control and prevention of meningococcal disease: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 46(No. RR-5):1–10
Cervós-Navarro J, Lafuente JV (1991) Traumatic brain injuries: structural changes. J Neurol Sci 103:3–14
Chan KK, Lowe J (2002) Techniques in neuropathology. In: Bancroft JD, Gamble M (eds) Theory and practice of histological techniques, 5th edn. Churchill Livingstone, London, Edinburgh, New York, pp 371–414
Cohen MA, Sprigg A, Whitby EH (2010) Subdural hemorrhage, intradural hemorrhage and hypoxia in the pediatric and perinatal post mortem: are they related? An observational study combining the use of post mortem pathology and magnetic resonance imaging. Forensic Sci Int 200:100–107
De Letter EA, Espeel MF, Craeymeersch ME et al (2003) Immunohistochemical demonstration of the amphetamine derivatives 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxyamphetamine (MDA) in human post-mortem brain tissues and the pituitary gland. Int J Legal Med 117:2–9
Detesky AS, Salit IE (1983) Complete heart block in meningococcemia. Ann Emerg Med 12:391–393
Dettmeyer R, Varchmin-Schultheiß K, Madea B (1998a) Intracranial plasma cell granuloma and homocystinuria. Pathol Res Pract 194:205–208
Dettmeyer R, Varchmin-Schultheiß K, Madea B (1998b) Sudden death of an 18-year-old man with homocystinuria and intracranial inflammatory pseudotumor (IPT). Forensic Sci Int 94:19–24
DiMaio VJM, Dana SE (2007) Handbook of forensic pathology, 2nd edn. Taylor & Francis, Boca Raton, London, New York
DiMaio SM, DiMaio VJ, Kirkpatrick JB (1980) Sudden unexpected death due to primary intracranial neoplasms. Am J Forensic Med Pathol 1:29–45
Dolinak D, Reichard R (2006) An overview of inflicted head injury in infants and young children, with a review of beta-amyloid precursor protein immunohistochemistry. Arch Pathol Lab Med 130:712–717
Dressler J, Hanisch U, Busuttil A (2005) Comments on Hausmann et al.: neuronal apoptosis following human brain injury. Int J Legal Med 119:177–178
Dressler J, Hanisch U, Kuhlisch E, Geiger KD (2007) Neuronal and glial apoptosis in human traumatic brain injury. Int J Legal Med 121:365–375
Duhaime AC, Alario AJ, Lewander WJ et al (1992) Head injury in very young children: mechanisms, injury types, and ophthalmologic findings in 100 hospitalized patients younger than 2 years of age. Pediatrics 90:179–185
Eberhart CG, Morrison A, Gyure KA, Frazier J, Smialek JE, Troncoso JC (2001) Decreasing incidence of sudden death due to undiagnosed primary intracranial tumors. Arch Pathol Lab Med 125:1024–1030
Eisenmenger W (1977) Zur histologischen und histochemischen Altersbestimmung gedeckter Hirnverletzungen. Med Habil, München
Emerson MV, Pieramici DJ, Stoessel KM, Berreen JP, Gariano RF (2001) Incidence and rate of disappearance of retinal hemorrhage in newborns. Ophthalmology 108:36–39
Förstl H, Haass C, Hemmer B, Meyer B, Halle M (2010) Boxing-acute complications and late sequelae: from concussion to dementia. Dtsch Arztebl Int 107:835–839
Fracasso T, Brinkmann B, Paulus W (2008) Sudden death due to subarachnoid bleeding from ecchordosis physaliphora. Int J Legal Med 122:225–227
Friderichsen C (1918) Nebennierenapoplexie bei kleinen Kindern. Jahrb Kinderheilk 87:109
Gago LC, Wegner RK, Capone A Jr, Williams GA (2003) Intraretinal hemorrhages and chronic subdural effusions: glutaric aciduria type 1 can be mistaken for shaken baby syndrome. Retina 23:724–726
Geddes JF, Whitwell HL, Graham DI (2000) Traumatic axonal injury: practical issues for diagnosis in medicolegal cases. Neuropathol Appl Neurobiol 26:105–116
Geddes JF, Tasker RC, Hackshaw AK, Nickols CD, Adams CGW, Whitwell HL, Scheimberg I (2003) Dural hemorrhage in non-traumatic infant deaths: does it explain the bleeding in “shaken baby syndrome”? Neuropathol Appl Neurobiol 29:14–22
Gentleman SM, Nash AJ, Sweeting CJ, Graham DI, Roberts GW (1993) ß-Amyloid precursor protein (ß-APP) as a marker of axonal injury in traumatic brain injury. Neurosci Lett 160:139–144
Gilliland MG, Luckenbach MW (1993) Are retinal hemorrhages found after resuscitation attempts? A study of the eyes of 169 children. Am J Forensic Med Pathol 14:187–192
Gilliland MG, Luthert P (2003) Why do histology on retinal haemorrhages in suspected non-accidental injury? Histopathology 43:592–602
Gilliland MG, Luckenbach MW, Chenier TC (1994) Systemic and ocular findings in 169 prospectively studied child deaths: retinal hemorrhages usually mean child abuse. Forensic Sci Int 68:117–132
Gilliland MG, Levin AV, Enzenauer RW et al (2007) Guidelines for postmortem protocol for ocular investigation of sudden unexplained infant death and suspected physical child abuse. Am J Forensic Med Pathol 28:323–329
Gleckman AM, Bell MD, Evans RJ, Smith TW (1999) Diffuse axonal injury in infants with nonaccidental craniocerebral trauma: enhanced detection by beta-amyloid precursor protein immunohistochemical staining. Arch Pathol Lab Med 123:146–151
Gleckman AM, Kessler SC, Smith TW (2000) Periadventitial extracranial vertebral artery hemorrhage in a case of shaken baby syndrome. J Forensic Sci 45:1151–1153
Goetting MG, Sowa B (1990) Retinal hemorrhage after cardiopulmonary resuscitation in children: an etiologic reevaluation. Pediatrics 85:585–588
Gumpert S, Maxeiner H (2008) Sturzbedingte tödliche Schädel-Hirn-Traumen. Rechtsmedizin 18:247–250
Halpern M, Citron BP (1971) Necrotizing angiitis associated with drug abuse. Am J Roentgenol 111:663–671
Hartman CA, Lindlar F (1987) Hirninfarkt nach traumatischer Karotisthrombose. Z Rechtsmed 99:219
Hauser R, Jankowski Z, Gos T, Krzyżanowski M (2001) Hemorrhages in head tissues during the asphyxiation process. Forensic Sci Int 124:235–236
Hausmann R (2002) Die Altersbestimmung von Hirnkontusionen bei gedecktem Schädel-Hirn-Trauma des Menschen, vol 25, Arbeitsmethoden der Medizinischen und Naturwissenschaftlichen Kriminalistik. Schmidt-Römhild, Lübeck
Hausmann R (2004) Timing of cortical contusions in human brain injury: morphological parameters for a forensic wound-age estimation. In: Tsokos M (ed) Forensic pathology reviews, vol 1. Humana Press Inc, Totowa, pp 53–75
Hausmann R, Betz P (2000) The time course of the vascular response to human brain injury – an immunohistochemical study. Int J Legal Med 113:288–292
Hausmann R, Betz P (2001) Course of glial immunoreactivity for vimentin, tenascin and alpha1-antichymotrypsin after traumatic injury to human brain. Int J Legal Med 114:338–342
Hausmann R, Betz P (2002) The course of MIB-1 expression by cerebral macrophages following human brain injury. Leg Med 4:79–83
Hausmann R, Kaiser A, Lang C, Bohnert M, Betz P (1999) A quantitative immunohistochemical study on the time-dependent course of acute inflammatory cellular response to human brain injury. Int J Legal Med 112:227–232
Hausmann R, Rieß R, Fieguth A, Betz P (2000) Immunohistochemical investigations on the course of astroglial GFAP expression following human brain injury. In J Legal Med 113:70–75
Hausmann R, Biermann T, Wiest I, Tübel J, Betz P (2004) Neuronal apoptosis following human brain injury. Int J Legal Med 118:32–36
Hausmann R, Vogel C, Seidl S, Betz P (2006) Value of morphological parameters for grading of brain swelling. Int J Legal Med 120:219–225
Hausmann R, Seidl S, Betz P (2007) Hypoxic changes in Purkinje cells of the human cerebellum. Int J Legal Med 121:175–183
Herczeg L, Gorombey S, Vaszily M (1995) Morphological damage to the central nervous system (CNS) following open heart surgery. Forensic Sci Int 79:103–111
Herr S, Pierce MC, Berger RP, Ford H, Pitetti RD (2004) Does Valsalva retinopathy occur in infants? An initial investigation in infants with vomiting caused by pyloric stenosis. Pediatrics 113:1658–1661
Horn M, Schote W (1992) Delayed neuronal death and delayed neuronal recovery in the human brain following global ischemia. Acta Neuropathol 85:79–87
Huntington RW, Cummings KL, Moe TI, O’Connell HV, Wybel R (1965) Discovery of fatal primary intracranial neoplasms at medicolegal autopsies. Cancer 18:117–127
Iino M, Nakatome M, Ogura Y, Fujimura H, Kuroki H, Inoue H et al (2003) Real-time PCR quantification of FE65 a ß-amyloid precursor protein-binding protein after traumatic brain injury in rats. Int J Legal Med 117:153–159
Ip M, Teo JG, Cheng AF (1995) Waterhouse-Friderichsen syndrome complicating primary biliary sepsis due to Pasteurella multocida in a patient with cirrhosis. J Clin Pathol 48:775–777
Ishigami A, Kubo S, Ikematsu K, Kitamura O, Tokunaga I, Gotohda T, Nakasono I (2004) An adult autopsy case of acute encephalopathy associated with influenza A virus. Leg Med 6:252–255
Ishikawa T, Zhu BL, Li DR, Zhao D, Michiue T, Maeda H (2006a) Postmortem stability of pituitary hormones in the human adenohypophysis. Leg Med 8:34–38
Ishikawa T, Zhu BL, Li DR, Michiue T, Maeda H (2006b) Age-dependent increase of clusterin in the human pituitary gland. Leg Med 8:28–33
Ishikawa T, Zhu BL, Miyaishi S, Ishizu H, Maeda H (2007) Increase of clusterin-containing follicles in the adenohypophysis of drug abusers. Int J Legal Med 121:395–402
Ishikawa T, Michiue T, Quan L, Zhao D, Komatsu A, Bessho Y, Maeda H (2009) Morphological and functional alterations in the adenohypophysis in cases of brain death. Leg Med 11:S234–S237
Itabashi HH, Andrews JM, Tomiyasu U et al (2007) Forensic neuropathology. A practical review of the fundamentals. Elsevier, Amsterdam
Iwasa M, Maeno Y, Inoue H, Koyama H, Matoba R (1996) Induction of apoptotic cell death in rat thymus and spleen after a bolus injection of methamphetamine. Int J Legal Med 109:23–28
Jacobs RF, His S, Wilson CB, Benjamin D, Smith AL, Morrow R (1983) Apparent meningococcemia: clinical features of disease due to Haemophilus influenzae and Neisseria meningitides. Pediatrics 7:469–472
Johnston DL, Braun D, Friendly D (1993) Accidental head trauma and retinal hemorrhage. Neurosurgery 33:231–234
Kanter RK (1986) Retinal hemorrhage after cardiopulmonary resuscitation or child abuse. J Pediatr 108:430–432
Kempe H, Silverman FN, Steele BF, Droegemueller W, Silver HK (1962) The battered child syndrome. JAMA 181:17–24
Kibayashi K, Shojo H (2002) Incipient Alzheimer’s disease as the underlying cause of a motor vehicle crash. Med Sci Law 42:233–236
Kind M (1991) Tödliche Basilaris-Thrombose nach Commotio cerebri. Verh Dtsch Ges Pathol 75:518
King J, Richards M, Tress B (1978) Cerebral arteritis associated with heroin abuse. Med J Aust 2:444–445
Kitamura O (1994) Immunohistochemical investigations of hypoxic/ischemic brain damage in forensic autopsy cases. Int J Legal Med 107:69–76
Kitamura O, Tokunaga I, Gotohda T, Kubo S (2007) Immunohistochemical investigation of dopaminergic terminal markers and caspaser-3 activation in the striatum of human methamphetamine users. Int J Legal Med 121:163–168
Klages U (1970) Spontaneous versus traumatic lethal subarachnoid hemorrhage. J Leg Med 67:67–86
Koda Y, Seto Y, Takeichi S, Kimura H (2003) Fatal subarachnoid hemorrhage complicating actinomycotic meningitis. Forensic Sci Int 134:169–171
Kominato Y, Matsui K, Hata Y, Matsui K, Kuwayama N, Ishizawa S, Takizawa H (2004) Acute subdural hematoma due to arteriovenous malformation primarily in dura mater: a case report. Leg Med 6:256–260
König P, Haller R (1985) Results of a study of a family with aggregated occurrence of bilateral symmetrical basal ganglia calcinosis. Eur Arch Psychiatry Neurol Sci 234:325–334
Krauland W (1961) Über die Quellen des akuten und chronischen subduralen Hämatoms. Thieme-Verlag, Stuttgart
Krauland W (1973) Über die Zeitbestimmung von Schädelhirnverletzungen. Beitr Gerichtl Med 30:226–251
Krauland W (1981) Die traumatische subarachnoidale Blutung. Z Rechtsmed 87:1–18
Krauland W (1982) Verletzungen der intrakraniellen Schlagadern. Springer, Berlin, Heidelberg, New York
Kreft F (1952) Über Todesfälle beim Boxen. Dtsch Gesundh 7:1559–1564
Lear-Kaul KC, Coughlin L, Dobersen MJ (2005) Sudden unexpected death in epilepsy: a retrospective study. Am J Forensic Med Pathol 26:11–17
Lee CH, Kim DW, Jeon GS, Roh EJ, Seo JH, Wang KCh, Cho SS (2001) Cerebellar alterations induced by chronic hypoxia: an immunohistochemical study using a chick embryonic model. Brain Res 901:271–276
Leestma JE (2009) Forensic neuropathology, 2nd edn. CRC Press/Taylor & Francis Group, Boca Raton
Li DR, Zhu BL, Ishikawa T, Zhao D, Michiue T, Maeda H (2006) Immunohistochemical distribution of S-100 protein in the cerebral cortex with regard to the cause of death in forensic autopsy. Leg Med 8:78–85
Lindboe CF, Svenes KB, Slordal L (1997) Sudden unexpected death in subjects with undiagnosed gliomas. Am J Forensic Med Pathol 18:271–275
Lindenberg R, Freytag E (1957) Morphology of cortical contusions. Arch Pathol 63:23–42
Mandani N, Repp AL, Seyoum B, Berhanu P (2007) Idiopathic hypoparathyroidism presenting with severe hypocalcemia and asymptomatic basal ganglia calcification followed by acute intracerebral bleed. Endocr Pract 13:487–492
Matsche J (2005) Primary cerebral neoplasms as a cause of sudden, unexpected death. In: Tsokos M (ed) Forensic pathology reviews, vol 2. Humana Press, Totowa, pp 45–58
Matschke J (2008) Historical overview of non-accidental head injury in toddlers and infants. Rechtsmedizin 18:7–8
Matschke J, Glatzel M (2008) Neuropathologische Begutachtung des nichtakzidentellen Schädel-Hirn-Traumas bei Säuglingen und Kleinkindern. Rechtsmedizin 18:29–35
Matschke J, Tsokos M (2001) Post-traumatic meningitis: histomorphological findings, post-mortem microbiology and forensic implications. Forensic Sci Int 115:199–205
Matschke J, Tsokos M (2005) Sudden unexpected death due to undiagnosed glioblastoma: report of three cases and review of the literature. Int J Legal Med 119:280–284
Matschke J, Tsokos M, Schulz F, Lockemann U (1999) Differential diagnostic aspects of forensically relevant findings in the brain stem. Arch Kriminol 203:108–116
Matschke J, Tsokos M, Püschel K (2000) Pilocytic astrocytoma of the brainstem as the cause of death in a 29-year-old man. Rechtsmedizin 10:221–225
Matschke J, Stavrou D, Püschel K (2002) Sudden unexpected death due to epidermoid cyst of the brain. Am J Forensic Med Pathol 23:368–370
Matschke J, Püschel K, Glatzel M (2009) Ocular pathology in shaken baby syndrome and other forms of infantile non-accidental head injury. Int J Legal Med 123:189–197
Matschke J, Glatzel M, Püschel K, Andresen H (2010) Fatalities in patients with epilepsy. Rechtsmedizin 20:437–446
Matsumoto H, Yamamoto K (1994) A case of sudden death by undiagnosed glioblastoma multiforme. Jpn J Legal Med 47:336–339
Maxeiner H, Finck GA (1989) Traumatischer Hirninfarkt bei mehrzeitig verlaufender Dissektion der extrakraniellen Arteria carotis interna. Unfallchirurg 92:321–327
McQuillen JB, McQuillen E, Morrow P (1988) Trauma, sport and malignant cerebral edema. Am J Forensic Med Pathol 9:12–15
Michiue T, Ishikawa T, Quan L, Li DR, Zhao D, Komatsu A, Zhu BL, Maeda H (2008) Single-stranded DNA as an immunohistochemical marker of neuronal damage in human brain: an analysis of autopsy material with regard to the cause of death. Forensic Sci Int 178:185–191
Mirza I, Wolk J, Toth L, Rostenberg P, Kranwinkel R, Sieber SC (2000) Waterhouse-Friderichsen syndrome secondary to Capnocytophaga canimorsus septicaemia and demonstration of bacteremia by peripheral blood smear. Arch Pathol Lab Med 124:859–863
Miyazaki T, Kojima T, Chikasue F, Yashiki M, Ito H (1990) Traumatic rupture of intracranial vertebral artery due to hyperextension of the head: reports on three cases. Forensic Sci Int 47:91–98
Mork SJ, Morild I, Giertsen JC (1986) Subependymoma and unexpected death. Forensic Sci Int 30:275–280
Munger CE, Peiffer RL, Bouldin TW, Kylstra JA, Thompson RL (1993) Ocular and associated neuropathologic observations in suspected whiplash shaken infant syndrome. A retrospective study of 12 cases. Am J Forensic Med Pathol 14:193–200
Nakatome M, Matoba R, Ogura Y et al (2002) Detection of cardiomyocyte apoptosis in forensic autopsy cases. Int J Legal Med 116:17–21
Nelson J, Frost JL, Schochet SS (1987) Sudden unexpected death in a 5-year-old boy with an unusual primary intracranial neoplasm. Am J Forensic Med Pathol 8:148–152
Ng I, Yeo TT, Tang WY, Soong R, Ng PY, Smith DR (2000) Apoptosis occurs after cerebral contusions in humans. Neurosurgery 46:949–956
Ng’walali PM, Yonemitsu K, Kibayashi K, Tsunenari S (2002) Neuropathological diagnosis of Alzheimer’s disease in forensic autopsy of elderly persons with fatal accident. Leg Med 4:223–231
Nogami M, Takatsu A, Endo N, Ishiyama I (1999a) IgG immunohistochemistry for the assessment of brain injuries in forensic autopsies. Leg Med 1:76–79
Nogami M, Takatsu A, Endo N, Ishiyama I (1999b) Immunohistochemical localization of heat shock protein 70 in the human medulla oblongata in forensic autopsies. Leg Med 1:198–203
Oehmichen M (2001) Brain hypoxia and ischemia. Schmidt-Römhild, Lübeck
Oehmichen M, König HG (eds) (1997) Neurotraumatology: biomechanic aspects, cytologic and molecular mechanisms. In: Research in legal medicine, Vol 17. Schmidt-Römhild, Lübeck, pp 239–259
Oehmichen M, Meissner C (2006) Cerebral hypoxia and ischemia: the forensic point of view: a review. J Forensic Sci 51:880–887
Oehmichen M, Raff G (1980) Timing of cortical contusion. Correlation between histomorphological alterations and post-traumatic interval. Z Rechtsmed 84:79–94
Oehmichen M, Eisenmenger W, Raff G, Berghaus G (1986) Brain macrophages in human cortical contusions as an indicator of survival period. Forensic Sci Int 30:281–301
Oehmichen M, Meißner C, Schmidt V, Pedal I, König HG, Saternus KS (1998) Axonal injury – a diagnostic tool in forensic neuropathology? A review. Forensic Sci Int 95:67–83
Oehmichen M, Meissner C, von Wurmb-Schwank N, Schwank T (2003) Methodological approach to brain hypoxia/ischemia as a fundamental problem in forensic neuropathology. Leg Med 5:190–201
Oehmichen M, Auer RN, König HG (2006) Forensic neuropathology and associated neuropathology. Springer, Berlin, Heidelberg, New York, Tokyo
Oehmichen M, Jakob S, Mann S, Saternus KS, Pedal I, Meissner C (2009) Macrophage subsets in mechanical brain injury (MBI) – a contribution to timing of MBI based on immunohistochemical methods: a pilot study. Leg Med 11:118–124
Ogata M, Tsuganezawa O (1999) Neuron-specific enolase as an effective immunohistochemical marker for injured axons after fatal brain injury. Int J Legal Med 113:19–25
Ommaya AK, Yarnell P (1969) Subdural hematoma after whiplash injury. Lancet 2:237–239
Orihara and Nakasono I (2002) Induction of apolipoprotein E after traumatic brain injury in forensic autopsy cases. Int J Legal Med 116:92–98
Orihara Y, Tsuda R, Ikematsu K, Nakasono I, Ogata M (2003) Immunohistochemical study on the induction of heme oxygenase-1 by traumatic brain injury. Leg Med 5:S278–S279
Padosch SH, Vogel P, Böttiger BW (2001) Neuronale Apoptose nach zerebraler Ischämie. Anaesthesist 50:905–920
Padosch SA, Dettmeyer RB, Schmidt PH, Musshoff F, Madea B (2006) Spinal epidural haematoma after blunt trauma to the neck and hyperflection of the cervical spine. Forensic Sci Int 159:230–234
Petito CK, Roberts B (1995) Evidence of apoptotic cell death in HIV encephalitis. Am J Pathol 146:1121–1130
Piette MHA, Pieters SEP, de Letter EA (2010) Evaluation of the agonal stress: can immunohistochemical detection of ubiquitin in the locus coeruleus be useful? Int J Leg Med 125(3):333–40, Epub 2010 Apr 16
Poon TP, Solis OG (1985) Sudden death due to massive intraventricular hemorrhage into an unsuspected ependymoma. Surg Neurol 24:63–66
Pounder DJ (1997) Shaken adult syndrome. Am J Forensic Med Pathol 18:321–324
Prahlow JA, Teot LA, Lantz PE, Stanton CA (1995) Sudden death in epilepsy due to an isolated subependymal giant cell astrocytoma of the septum pellucidum. Am J Forensic Med Pathol 16:30–37
Preusser M, Kitzwoegener M, Budka H, Brugger S (2007) Bilateral striopallidodentate calcification (Fahr’s syndrome) and multiple system atrophy in a patient with longstanding hypoparathyroidism. Neuropathology 27:453–456
Quan L, Zhu BL, Ishida K, Oritani S, Taniguchi M, Fujita MQ, Maeda H (2001) Intranuclear ubiquitin immunoreactivity of the pigmented neurons of the substantia nigra in fatal acute mechanical asphyxiation and drowning. Int J Legal Med 115:6–11
Quan L, Ishikawa T, Michique T et al (2005a) Ubiquitin-immunoreactive structures in the midbrain of methamphetamine abusers. Leg Med 7:144–150
Quan L, Ishikawa T, Michiue T, Li DR, Zhao D, Zhu BL, Maeda H (2005b) Quantitative analysis of ubiquitin-immunoreactivity in the midbrain periaqueductal gray matter with regard to the causes of death in forensic autopsy. Leg Med 7:151–156
Quan L, Ishikawa T, Michiue T, Li DR, Zhao D, Zhu BL, Maeda H (2005c) Ubiquitin immunoreactivity in the midbrain as a marker of stress to motor nervous systems in fatal injury. Leg Med 7:157–163
Racette S, Sauvageau A (2007) Brain arteriovenous malformation and its implication in forensic pathology. J Forensic Sci 52:189–191
Raul JS, Roth S, Ludes B, Willinger R (2008) Influence of the benign enlargement of the subarachnoid space on the bridging veins strain during a shaking event: a finite element study. Int J Legal Med 12:337–340
Reichard RR, White CL 3rd, Hladik CL, Dolinak D (2003) Beta-amyloid precursor protein staining in nonhomicidal pediatric medicolegal autopsies. J Neuropathol Exp Neurol 62:237–247
Riffenburgh RS, Sathyavagiswaran L (1991) The eyes of child abuse victims: autopsy findings. J Forensic Sci 36:741–747
Riordan FAI, Marzouk O, Thomson APJ, Sills JA, Hart CA (1995) The changing presentations of meningococcal disease. Eur J Pediatr 154:472–474
Riße M, Weiler G (1984) Heroinsucht als seltene Ursache einer symmetrischen Pallidumnekrose. Z Rechtsmed 93:227–235
Roth S, Raul JS, Ludes B, Willinger R (2007) Finite element analysis of impact and shaking inflicted to a child. Int J Legal Med 121:223–228
Ryan CA, Wenman W, Hennigsen C, Tse S (1993) Fatal childhood pneumococcal Waterhouse-Friderichsen syndrome. Pediatr Infect Dis J 12:250–251
Saito K, Takda A, Kuroda N, Hara M, Arai M, Ro A (2009) Traumatic dissection of extracranial vertebral artery with massive subtentorial cerebral infarction: report of an autopsy case. Leg Med 11:S520–S522
Sakai K, Takatsu A, Shigeta A, Abe S, Ikegami M, Takagi K (2007) Sudden death due to undiagnosed acute promyelocytic leukaemia: a case report. Int J Legal Med 121:311–314
Sato M, Hashimoto H, Kosaka F (1990) Histological changes of neuronal damage in vegetative dogs induced by 18 minutes of complete global brain ischemia: two phase damage of Purkinje cells and hippocampal CA1 pyramidal cells. Acta Neuropathol 80:527–534
Schwarz KO, Perper JA, Rozin I (1987) Sudden, unexpected death due to fourth ventricular subependymoma. Am J Forensic Med Pathol 8:153–157
Sezen F (1971) Retinal haemorrhages in newborn infants. Br J Ophthalmol 55:248–253
Sheriff FE, Bridges LR, Sivaloganatham S (1994) Early detection of axonal injury after human head trauma using immunocytochemistry for ß-amyloid protein. Acta Neuropathol 87:55–62
Sherriff FE, Bridges LR, Sivaloganathan S (1994) Early detection of axonal injury after human head trauma using immunocytochemistry for beta-amyloid precursor protein. Acta Neuropathol 87:55–62
Simonsen J (1963) Traumatic subarachnoid hemorrhage in alcohol intoxication. J Forensic Sci 8:97–116
Simonsen J (1984) Fatal subarachnoid haemorrhages in relation to minor injuries in Denmark from 1967 to 1981. Forensic Sci Int 24:57–63
Sperhake JP, Tsokos M (2004) Pathological features of Waterhouse-Friderichsen syndrome in infancy and childhood. In: Toskos M (ed) Forensic pathology reviews, vol 1. Humana Press Inc, Totowa, pp 219–231
Sperling MR (2001) Sudden unexplained death in epilepsy. Epilepsy Curr 1:21–23
Squier W, Mack J (2009) The neuropathology of infant subdural haemorrhage. Forensic Sci Int 187:6–13
Strassmann G (1949) Formation of hemosiderin after traumatic and spontaneous cerebral hemorrhages. Arch Pathol 47:205–210
Strassmann G, Helpern M (1968) Tödliche Hirnverletzungen im Boxkampf. Dtsch Zschr Gerichtl Med 63:70–83
Suárez-Peñanranda JM, Rodríguez-Calvo MS, Ortiz-REy JA et al (2002) Demonstration of apoptosis in human skin injuries as an indicator of vital reaction. Int J Legal Med 116:109–112
Suzuki A, Shiraki K (2001) Tumor cell “dead or alive”: caspase and surviving regulate cell death, cell cycle and cell survival. Histol Histopathol 16:583–593
Tao L, Chen X, Qin Z, Bian S (2006) Could NF-kB and caspase-3 be markers for estimation of post-interval of human traumatic brain injury? Forensic Sci Int 162:174–177
Tardieu A (1860) Étude medico-légale sur les sévices et mauvais traitements exercés sur des enfants. Annales d’Hygiène Publique et de Medicine Légale 13:361–398
Thornstedt H, Voigt GE (1960) Tödliche, basale Subarachnoidalblutung nach Trauma. Dtsch Zschr Gerichtl Med 50:254–277
Tsokos M (2003) Fatal Waterhouse-Friderichsen syndrome due to Ewingella americana infection. Am J Forensic Med Pathol 24:41–44
Tsokos M, Püschel K (2001) Postmortem bacteriology in forensic pathology: diagnostic value and interpretation. Leg Med 3:15–22
Tyagi AK, Willshaw HE, Ainsworth JR (1997) Unilateral retinal haemorrhages in non-accidental injury. Lancet 349:1224
Tyagi AK, Scotcher S, Kozeis N, Willshaw HE (1998) Can convulsions alone cause retinal haemorrhages in infants? Br J Ophthalmol 82:659–660
Uemura K, Harada K, Sadmitsu D, Tsuruta R, Takahashi M, Aki T, Yasuhara M, Maekawa T, Yoshida K (2001) Apoptotic and necrotic brain lesions in a fatal case of carbon monoxide poisoning. Forensic Sci Int 116:213–219
Unger PD, Song S, Taff ML, Schwarz IS (1984) Sudden death in a patient with von Recklinghausen’s neurofibromatosis. Am J Forensic Med Pathol 5:175–179
Unkrig S, Gulotta F, Madea B (2010) Morbus Fahr – considerations on a case of sudden death. Forensic Sci Int 204:e12–e15
Unterharnscheidt F (1970) About boxing: review of historical and medical aspects. Tex Rep Biol Med 28:421–495
Unterharnscheidt F (1975) Injuries due to boxing and other sports. In: Winken PJ, Bruyn GW (eds) Handbook of clinical neurology, vol 23., pp 527–593
Varchmin-Schultheiß K, Holtz J, Horn M (1990) Waterhouse-Friderichsen-Syndrom im Erwachsenenalter. Beitr Gerichtl Med 48:229–231
Viitanen M, Johansson K, Bogdanovic N et al (1998) Alzheimer changes are common in aged drivers killed in single car crashes and at intersections. Forensic Sci Int 96:115–127
Vowles GH, Cl S, Cameron JM (1987) Diffuse axonal injury in early infancy. J Clin Pathol 40:185–189
Waterhouse R (1911) A case of suprarenal apoplexy. Lancet 1:577
Weedn VW, Mansour AM, Nichols MM (1990) Retinal hemorrhage in an infant after cardiopulmonary resuscitation. Am J Forensic Med Pathol 11:79–82
Weiler G, Reinhardt V, Nau HE, Gerhard L (1980) Contribution to intracranial “traumatic aneurysm”. Z Rechtsmed 85:225–233
Wick R, Byard RW (2006) Mechanisms of unexpected and/or sudden death in Lafora disease. Forensic Sci Int 163:144–147
Wojahn H (1970) Klärung einer Abtreibung mit zentraler Luftembolie nach 4 Jahren. Beitr Gerichtl Med 27:97–100
Zappi E, Zappi M, Breithaupt M, Zugibe FT (1993) Cerebral intraventricular lipoma and sudden death. J Forensic Sci 38:489–492
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Dettmeyer, R.B. (2011). Forensic Neuropathology. In: Forensic Histopathology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-20659-7_20
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