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Forensic Neuropathology

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Forensic Histopathology

Abstract

Forensic neuropathology has established itself as an independent discipline within forensic science. More specific information can be found by referring to the relevant literature (e.g., Leestma 2009; Oehmichen et al. 2006; Itabashi et al. 2007; Chan and Lowe 2002; Oehmichen and König 1997; Bratzke and Krauland 1988; Bratzke et al. 1986; Krauland 1973, 1981, 1982).

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References

  • Abu AL, Ragheb SY, Koussous KJ, Amr SS (1986) Intracranial neoplasms associated with sudden death: a report of seven cases and a review of the literature. Med Sci Law 26:270–272

    Google Scholar 

  • Althoff H (1982) Zur Ätiologie und Pathogenese des Waterhouse-Friderichsen-Syndroms. Z Rechtsmed 88:173–184

    PubMed  CAS  Google Scholar 

  • American Academy of Pediatrics (2001) Shaken baby syndrome: rotational cranial injuries – technical report. Pediatrics 108:206–210

    Google Scholar 

  • Amine ARC (1997) Neurosurgical complications of heroin addiction: brain abscess and mycotic aneurysm. Surg Neurol 7:385–386

    Google Scholar 

  • Andersen SN, Skullerud K (1999) Hypoxic/ischaemic brain damage, especially pallidal lesions, in heroin addicts. Forensic Sci Int 102:51–59

    PubMed  CAS  Google Scholar 

  • Andrade DM, Ackerley CA, Minett TS, Teive HA, Bohlega S, Scherer SW, Minassian BA (2003) Skin biopsy in Lafora disease: genotype-phenotype correlations and diagnostic pitfalls. Neurology 61:1611–1614

    PubMed  CAS  Google Scholar 

  • Arlotti SA, Forbes BJ, Dias MS, Bonsall DJ (2007) Unilateral retinal hemorrhages in shaken baby syndrome. J AAPOS 11:175–178

    PubMed  Google Scholar 

  • Balko MG, Schultz DL (1999) Sudden death due to a central neurocytoma. Am J Forensic Med Pathol 20:180–183

    PubMed  CAS  Google Scholar 

  • Bauer M, Lang C, Patzelt D (2001) Sudden death due to pituitary apoplexy. Leg Med 3:183–186

    CAS  Google Scholar 

  • Baum JD, Bulpitt CJ (1970) Retinal and conjunctival haemorrhage in the newborn. Arch Dis Child 45:344–349

    PubMed  CAS  Google Scholar 

  • Betz P, Püschel K, Miltner E, Lignitz E, Eisenmenger W (1996) Morphometrical analysis of retinal hemorrhages in the shaken baby syndrome. Forensic Sci Int 78:71–80

    PubMed  CAS  Google Scholar 

  • Black M, Graham DI (2002) Sudden unexplained death in adults caused by intracranial pathology. J Clin Pathol 55:44–50

    PubMed  CAS  Google Scholar 

  • Böhm N (1982) Adrenal, cutaneous and myocardial lesions in fulminating endotoxinemia (Waterhouse-Friderichsen syndrome). Pathol Res Pract 174:92–105

    PubMed  Google Scholar 

  • Bowen DA (1984) Ruptured berry aneurysms: a clinical, pathological and forensic review. Forensic Sci Int 26:227–234

    PubMed  CAS  Google Scholar 

  • Bratzke H, Eisenmenger W (1989) Traumatische Ruptur der Arteria communicans anterior. Beitr Gerichtl Med XLVII:437–440

    Google Scholar 

  • Bratzke H, Krauland W (1988) Zur Genese und Morphologie des traumatischen Mediainfarktes (Fallbericht). In: Bauer G (ed) Gerichtsmedizin – Festschrift für Wilhelm Holczabek. Deutike-Verlag, Wien

    Google Scholar 

  • Bratzke H, Püschel K, Colmant HJ (1986) The phenomena and morphology for fatal aneurysms causing brain hemorrhage. Z Rechtsmed 96:245–273

    PubMed  CAS  Google Scholar 

  • Buschmann CT, Matejic D, Semm K, Tsokos M (2008) Lhermitte-Duclos syndrome as the cause of sudden death. Rechtsmedizin 19:34–36

    Google Scholar 

  • Büttner A, Weis S (2004) Central nervous system alterations in drug abuse. In: Tsokos M (ed) Forensic pathology reviews, vol I. Humana Press, Totowa, pp 79–136

    Google Scholar 

  • Büttner A, Winkler PA, Eisenmenger W, Weis S (1997) Colloid cysts of the third ventricle with fatal outcome: a report of two cases and review of the literature. Int J Legal Med 110:260–266

    PubMed  Google Scholar 

  • Büttner A, Gall C, Mall C, Weis S (1999) Unexpected death in persons with symptomatic epilepsy due to glial brain tumors: a report of two cases and review of the literature. Forensic Sci Int 100:127–136

    PubMed  Google Scholar 

  • Büttner A, Mall G, Penning R, Weis S (2000) The neuropathology of heroin abuse. Forensic Sci Int 113:435–442

    PubMed  Google Scholar 

  • Büttner A, Weis S, Mall G, Gall C, Eisenmenger W (2001) The diagnostic relevance of cerebral amyloid angiopathy in the setting of forensic pathology – a report of two cases and review of the literature. Leg Med 3:141–148

    Google Scholar 

  • Büttner A, Rohrmoser K, Mall G, Penning R, Weis S (2006) Widespread axonal damage in the brain of drug abusers as evidenced by accumulation of beta-amyloid precursor protein (beta-APP): an immunohistochemical investigation. Addiction 101:1339–1346

    PubMed  Google Scholar 

  • Byard RW (2004) Neurologic conditions. In: Sudden death in infancy, childhood and adolescence, 2nd edn. Cambridge University Press, Cambridge, pp 366–372, Chapter 8

    Google Scholar 

  • Byard RW, Bourne AJ, Hanieh A (1991) Sudden and unexpected death due to hemorrhage from occult central nervous system lesions. A pediatric autopsy study. Pediatr Neurosurg 17:88–94

    PubMed  Google Scholar 

  • Caffey J (1972) On the theory and practice of shaking infants. Its potential residual effects of permanent brain damage and mental retardation. Am J Dis Child 124:161–169

    PubMed  CAS  Google Scholar 

  • Caparros-Lefebvre D, Policard J, Sengler C, Benabdallah E, Colombani S, Rigal M (2005) Bipallidal haemorrhage after ethylene glycol intoxication. Neuroradiology 47:105–107

    PubMed  CAS  Google Scholar 

  • Centers for Disease Controal – CDC (1997) Control and prevention of meningococcal disease: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 46(No. RR-5):1–10

    Google Scholar 

  • Cervós-Navarro J, Lafuente JV (1991) Traumatic brain injuries: structural changes. J Neurol Sci 103:3–14

    Google Scholar 

  • Chan KK, Lowe J (2002) Techniques in neuropathology. In: Bancroft JD, Gamble M (eds) Theory and practice of histological techniques, 5th edn. Churchill Livingstone, London, Edinburgh, New York, pp 371–414

    Google Scholar 

  • Cohen MA, Sprigg A, Whitby EH (2010) Subdural hemorrhage, intradural hemorrhage and hypoxia in the pediatric and perinatal post mortem: are they related? An observational study combining the use of post mortem pathology and magnetic resonance imaging. Forensic Sci Int 200:100–107

    PubMed  Google Scholar 

  • De Letter EA, Espeel MF, Craeymeersch ME et al (2003) Immunohistochemical demonstration of the amphetamine derivatives 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxyamphetamine (MDA) in human post-mortem brain tissues and the pituitary gland. Int J Legal Med 117:2–9

    PubMed  Google Scholar 

  • Detesky AS, Salit IE (1983) Complete heart block in meningococcemia. Ann Emerg Med 12:391–393

    Google Scholar 

  • Dettmeyer R, Varchmin-Schultheiß K, Madea B (1998a) Intracranial plasma cell granuloma and homocystinuria. Pathol Res Pract 194:205–208

    PubMed  CAS  Google Scholar 

  • Dettmeyer R, Varchmin-Schultheiß K, Madea B (1998b) Sudden death of an 18-year-old man with homocystinuria and intracranial inflammatory pseudotumor (IPT). Forensic Sci Int 94:19–24

    PubMed  CAS  Google Scholar 

  • DiMaio VJM, Dana SE (2007) Handbook of forensic pathology, 2nd edn. Taylor & Francis, Boca Raton, London, New York

    Google Scholar 

  • DiMaio SM, DiMaio VJ, Kirkpatrick JB (1980) Sudden unexpected death due to primary intracranial neoplasms. Am J Forensic Med Pathol 1:29–45

    PubMed  CAS  Google Scholar 

  • Dolinak D, Reichard R (2006) An overview of inflicted head injury in infants and young children, with a review of beta-amyloid precursor protein immunohistochemistry. Arch Pathol Lab Med 130:712–717

    PubMed  CAS  Google Scholar 

  • Dressler J, Hanisch U, Busuttil A (2005) Comments on Hausmann et al.: neuronal apoptosis following human brain injury. Int J Legal Med 119:177–178

    PubMed  CAS  Google Scholar 

  • Dressler J, Hanisch U, Kuhlisch E, Geiger KD (2007) Neuronal and glial apoptosis in human traumatic brain injury. Int J Legal Med 121:365–375

    PubMed  CAS  Google Scholar 

  • Duhaime AC, Alario AJ, Lewander WJ et al (1992) Head injury in very young children: mechanisms, injury types, and ophthalmologic findings in 100 hospitalized patients younger than 2 years of age. Pediatrics 90:179–185

    PubMed  CAS  Google Scholar 

  • Eberhart CG, Morrison A, Gyure KA, Frazier J, Smialek JE, Troncoso JC (2001) Decreasing incidence of sudden death due to undiagnosed primary intracranial tumors. Arch Pathol Lab Med 125:1024–1030

    PubMed  CAS  Google Scholar 

  • Eisenmenger W (1977) Zur histologischen und histochemischen Altersbestimmung gedeckter Hirnverletzungen. Med Habil, München

    Google Scholar 

  • Emerson MV, Pieramici DJ, Stoessel KM, Berreen JP, Gariano RF (2001) Incidence and rate of disappearance of retinal hemorrhage in newborns. Ophthalmology 108:36–39

    PubMed  CAS  Google Scholar 

  • Förstl H, Haass C, Hemmer B, Meyer B, Halle M (2010) Boxing-acute complications and late sequelae: from concussion to dementia. Dtsch Arztebl Int 107:835–839

    PubMed  Google Scholar 

  • Fracasso T, Brinkmann B, Paulus W (2008) Sudden death due to subarachnoid bleeding from ecchordosis physaliphora. Int J Legal Med 122:225–227

    PubMed  CAS  Google Scholar 

  • Friderichsen C (1918) Nebennierenapoplexie bei kleinen Kindern. Jahrb Kinderheilk 87:109

    Google Scholar 

  • Gago LC, Wegner RK, Capone A Jr, Williams GA (2003) Intraretinal hemorrhages and chronic subdural effusions: glutaric aciduria type 1 can be mistaken for shaken baby syndrome. Retina 23:724–726

    PubMed  Google Scholar 

  • Geddes JF, Whitwell HL, Graham DI (2000) Traumatic axonal injury: practical issues for diagnosis in medicolegal cases. Neuropathol Appl Neurobiol 26:105–116

    PubMed  CAS  Google Scholar 

  • Geddes JF, Tasker RC, Hackshaw AK, Nickols CD, Adams CGW, Whitwell HL, Scheimberg I (2003) Dural hemorrhage in non-traumatic infant deaths: does it explain the bleeding in “shaken baby syndrome”? Neuropathol Appl Neurobiol 29:14–22

    PubMed  CAS  Google Scholar 

  • Gentleman SM, Nash AJ, Sweeting CJ, Graham DI, Roberts GW (1993) ß-Amyloid precursor protein (ß-APP) as a marker of axonal injury in traumatic brain injury. Neurosci Lett 160:139–144

    PubMed  CAS  Google Scholar 

  • Gilliland MG, Luckenbach MW (1993) Are retinal hemorrhages found after resuscitation attempts? A study of the eyes of 169 children. Am J Forensic Med Pathol 14:187–192

    PubMed  CAS  Google Scholar 

  • Gilliland MG, Luthert P (2003) Why do histology on retinal haemorrhages in suspected non-accidental injury? Histopathology 43:592–602

    PubMed  CAS  Google Scholar 

  • Gilliland MG, Luckenbach MW, Chenier TC (1994) Systemic and ocular findings in 169 prospectively studied child deaths: retinal hemorrhages usually mean child abuse. Forensic Sci Int 68:117–132

    PubMed  CAS  Google Scholar 

  • Gilliland MG, Levin AV, Enzenauer RW et al (2007) Guidelines for postmortem protocol for ocular investigation of sudden unexplained infant death and suspected physical child abuse. Am J Forensic Med Pathol 28:323–329

    PubMed  CAS  Google Scholar 

  • Gleckman AM, Bell MD, Evans RJ, Smith TW (1999) Diffuse axonal injury in infants with nonaccidental craniocerebral trauma: enhanced detection by beta-amyloid precursor protein immunohistochemical staining. Arch Pathol Lab Med 123:146–151

    PubMed  CAS  Google Scholar 

  • Gleckman AM, Kessler SC, Smith TW (2000) Periadventitial extracranial vertebral artery hemorrhage in a case of shaken baby syndrome. J Forensic Sci 45:1151–1153

    PubMed  CAS  Google Scholar 

  • Goetting MG, Sowa B (1990) Retinal hemorrhage after cardiopulmonary resuscitation in children: an etiologic reevaluation. Pediatrics 85:585–588

    PubMed  CAS  Google Scholar 

  • Gumpert S, Maxeiner H (2008) Sturzbedingte tödliche Schädel-Hirn-Traumen. Rechtsmedizin 18:247–250

    Google Scholar 

  • Halpern M, Citron BP (1971) Necrotizing angiitis associated with drug abuse. Am J Roentgenol 111:663–671

    CAS  Google Scholar 

  • Hartman CA, Lindlar F (1987) Hirninfarkt nach traumatischer Karotisthrombose. Z Rechtsmed 99:219

    Google Scholar 

  • Hauser R, Jankowski Z, Gos T, Krzyżanowski M (2001) Hemorrhages in head tissues during the asphyxiation process. Forensic Sci Int 124:235–236

    PubMed  CAS  Google Scholar 

  • Hausmann R (2002) Die Altersbestimmung von Hirnkontusionen bei gedecktem Schädel-Hirn-Trauma des Menschen, vol 25, Arbeitsmethoden der Medizinischen und Naturwis­sens­chaftlichen Kriminalistik. Schmidt-Römhild, Lübeck

    Google Scholar 

  • Hausmann R (2004) Timing of cortical contusions in human brain injury: morphological parameters for a forensic wound-age estimation. In: Tsokos M (ed) Forensic pathology reviews, vol 1. Humana Press Inc, Totowa, pp 53–75

    Google Scholar 

  • Hausmann R, Betz P (2000) The time course of the vascular response to human brain injury – an immunohistochemical study. Int J Legal Med 113:288–292

    PubMed  CAS  Google Scholar 

  • Hausmann R, Betz P (2001) Course of glial immunoreactivity for vimentin, tenascin and alpha1-antichymotrypsin after traumatic injury to human brain. Int J Legal Med 114:338–342

    PubMed  CAS  Google Scholar 

  • Hausmann R, Betz P (2002) The course of MIB-1 expression by cerebral macrophages following human brain injury. Leg Med 4:79–83

    CAS  Google Scholar 

  • Hausmann R, Kaiser A, Lang C, Bohnert M, Betz P (1999) A quantitative immunohistochemical study on the time-dependent course of acute inflammatory cellular response to human brain injury. Int J Legal Med 112:227–232

    PubMed  CAS  Google Scholar 

  • Hausmann R, Rieß R, Fieguth A, Betz P (2000) Immuno­histochemical investigations on the course of astroglial GFAP expression following human brain injury. In J Legal Med 113:70–75

    CAS  Google Scholar 

  • Hausmann R, Biermann T, Wiest I, Tübel J, Betz P (2004) Neuronal apoptosis following human brain injury. Int J Legal Med 118:32–36

    PubMed  CAS  Google Scholar 

  • Hausmann R, Vogel C, Seidl S, Betz P (2006) Value of morphological parameters for grading of brain swelling. Int J Legal Med 120:219–225

    PubMed  CAS  Google Scholar 

  • Hausmann R, Seidl S, Betz P (2007) Hypoxic changes in Purkinje cells of the human cerebellum. Int J Legal Med 121:175–183

    PubMed  CAS  Google Scholar 

  • Herczeg L, Gorombey S, Vaszily M (1995) Morphological damage to the central nervous system (CNS) following open heart surgery. Forensic Sci Int 79:103–111

    Google Scholar 

  • Herr S, Pierce MC, Berger RP, Ford H, Pitetti RD (2004) Does Valsalva retinopathy occur in infants? An initial investigation in infants with vomiting caused by pyloric stenosis. Pediatrics 113:1658–1661

    PubMed  Google Scholar 

  • Horn M, Schote W (1992) Delayed neuronal death and delayed neuronal recovery in the human brain following global ischemia. Acta Neuropathol 85:79–87

    PubMed  CAS  Google Scholar 

  • Huntington RW, Cummings KL, Moe TI, O’Connell HV, Wybel R (1965) Discovery of fatal primary intracranial neoplasms at medicolegal autopsies. Cancer 18:117–127

    PubMed  Google Scholar 

  • Iino M, Nakatome M, Ogura Y, Fujimura H, Kuroki H, Inoue H et al (2003) Real-time PCR quantification of FE65 a ß-amyloid precursor protein-binding protein after traumatic brain injury in rats. Int J Legal Med 117:153–159

    PubMed  Google Scholar 

  • Ip M, Teo JG, Cheng AF (1995) Waterhouse-Friderichsen syndrome complicating primary biliary sepsis due to Pasteurella multocida in a patient with cirrhosis. J Clin Pathol 48:775–777

    PubMed  CAS  Google Scholar 

  • Ishigami A, Kubo S, Ikematsu K, Kitamura O, Tokunaga I, Gotohda T, Nakasono I (2004) An adult autopsy case of acute encephalopathy associated with influenza A virus. Leg Med 6:252–255

    Google Scholar 

  • Ishikawa T, Zhu BL, Li DR, Zhao D, Michiue T, Maeda H (2006a) Postmortem stability of pituitary hormones in the human adenohypophysis. Leg Med 8:34–38

    CAS  Google Scholar 

  • Ishikawa T, Zhu BL, Li DR, Michiue T, Maeda H (2006b) Age-dependent increase of clusterin in the human pituitary gland. Leg Med 8:28–33

    CAS  Google Scholar 

  • Ishikawa T, Zhu BL, Miyaishi S, Ishizu H, Maeda H (2007) Increase of clusterin-containing follicles in the adenohypophysis of drug abusers. Int J Legal Med 121:395–402

    PubMed  Google Scholar 

  • Ishikawa T, Michiue T, Quan L, Zhao D, Komatsu A, Bessho Y, Maeda H (2009) Morphological and functional alterations in the adenohypophysis in cases of brain death. Leg Med 11:S234–S237

    Google Scholar 

  • Itabashi HH, Andrews JM, Tomiyasu U et al (2007) Forensic neuropathology. A practical review of the fundamentals. Elsevier, Amsterdam

    Google Scholar 

  • Iwasa M, Maeno Y, Inoue H, Koyama H, Matoba R (1996) Induction of apoptotic cell death in rat thymus and spleen after a bolus injection of methamphetamine. Int J Legal Med 109:23–28

    PubMed  CAS  Google Scholar 

  • Jacobs RF, His S, Wilson CB, Benjamin D, Smith AL, Morrow R (1983) Apparent meningococcemia: clinical features of disease due to Haemophilus influenzae and Neisseria meningitides. Pediatrics 7:469–472

    Google Scholar 

  • Johnston DL, Braun D, Friendly D (1993) Accidental head trauma and retinal hemorrhage. Neurosurgery 33:231–234

    Google Scholar 

  • Kanter RK (1986) Retinal hemorrhage after cardiopulmonary resuscitation or child abuse. J Pediatr 108:430–432

    PubMed  CAS  Google Scholar 

  • Kempe H, Silverman FN, Steele BF, Droegemueller W, Silver HK (1962) The battered child syndrome. JAMA 181:17–24

    PubMed  CAS  Google Scholar 

  • Kibayashi K, Shojo H (2002) Incipient Alzheimer’s disease as the underlying cause of a motor vehicle crash. Med Sci Law 42:233–236

    PubMed  Google Scholar 

  • Kind M (1991) Tödliche Basilaris-Thrombose nach Commotio cerebri. Verh Dtsch Ges Pathol 75:518

    Google Scholar 

  • King J, Richards M, Tress B (1978) Cerebral arteritis associated with heroin abuse. Med J Aust 2:444–445

    PubMed  CAS  Google Scholar 

  • Kitamura O (1994) Immunohistochemical investigations of hypoxic/ischemic brain damage in forensic autopsy cases. Int J Legal Med 107:69–76

    PubMed  CAS  Google Scholar 

  • Kitamura O, Tokunaga I, Gotohda T, Kubo S (2007) Immuno­histochemical investigation of dopaminergic terminal markers and caspaser-3 activation in the striatum of human methamphetamine users. Int J Legal Med 121:163–168

    PubMed  Google Scholar 

  • Klages U (1970) Spontaneous versus traumatic lethal subarachnoid hemorrhage. J Leg Med 67:67–86

    CAS  Google Scholar 

  • Koda Y, Seto Y, Takeichi S, Kimura H (2003) Fatal subarachnoid hemorrhage complicating actinomycotic meningitis. Forensic Sci Int 134:169–171

    PubMed  Google Scholar 

  • Kominato Y, Matsui K, Hata Y, Matsui K, Kuwayama N, Ishizawa S, Takizawa H (2004) Acute subdural hematoma due to arteriovenous malformation primarily in dura mater: a case report. Leg Med 6:256–260

    Google Scholar 

  • König P, Haller R (1985) Results of a study of a family with aggregated occurrence of bilateral symmetrical basal ganglia calcinosis. Eur Arch Psychiatry Neurol Sci 234:325–334

    PubMed  Google Scholar 

  • Krauland W (1961) Über die Quellen des akuten und chronischen subduralen Hämatoms. Thieme-Verlag, Stuttgart

    Google Scholar 

  • Krauland W (1973) Über die Zeitbestimmung von Schädelhirn­verletzungen. Beitr Gerichtl Med 30:226–251

    PubMed  CAS  Google Scholar 

  • Krauland W (1981) Die traumatische subarachnoidale Blutung. Z Rechtsmed 87:1–18

    PubMed  CAS  Google Scholar 

  • Krauland W (1982) Verletzungen der intrakraniellen Schlagadern. Springer, Berlin, Heidelberg, New York

    Google Scholar 

  • Kreft F (1952) Über Todesfälle beim Boxen. Dtsch Gesundh 7:1559–1564

    Google Scholar 

  • Lear-Kaul KC, Coughlin L, Dobersen MJ (2005) Sudden unexpected death in epilepsy: a retrospective study. Am J Forensic Med Pathol 26:11–17

    PubMed  Google Scholar 

  • Lee CH, Kim DW, Jeon GS, Roh EJ, Seo JH, Wang KCh, Cho SS (2001) Cerebellar alterations induced by chronic hypoxia: an immunohistochemical study using a chick embryonic model. Brain Res 901:271–276

    PubMed  CAS  Google Scholar 

  • Leestma JE (2009) Forensic neuropathology, 2nd edn. CRC Press/Taylor & Francis Group, Boca Raton

    Google Scholar 

  • Li DR, Zhu BL, Ishikawa T, Zhao D, Michiue T, Maeda H (2006) Immunohistochemical distribution of S-100 protein in the cerebral cortex with regard to the cause of death in forensic autopsy. Leg Med 8:78–85

    CAS  Google Scholar 

  • Lindboe CF, Svenes KB, Slordal L (1997) Sudden unexpected death in subjects with undiagnosed gliomas. Am J Forensic Med Pathol 18:271–275

    PubMed  CAS  Google Scholar 

  • Lindenberg R, Freytag E (1957) Morphology of cortical contusions. Arch Pathol 63:23–42

    Google Scholar 

  • Mandani N, Repp AL, Seyoum B, Berhanu P (2007) Idiopathic hypoparathyroidism presenting with severe hypocalcemia and asymptomatic basal ganglia calcification followed by acute intracerebral bleed. Endocr Pract 13:487–492

    Google Scholar 

  • Matsche J (2005) Primary cerebral neoplasms as a cause of sudden, unexpected death. In: Tsokos M (ed) Forensic pathology reviews, vol 2. Humana Press, Totowa, pp 45–58

    Google Scholar 

  • Matschke J (2008) Historical overview of non-accidental head injury in toddlers and infants. Rechtsmedizin 18:7–8

    Google Scholar 

  • Matschke J, Glatzel M (2008) Neuropathologische Begutachtung des nichtakzidentellen Schädel-Hirn-Traumas bei Säuglingen und Kleinkindern. Rechtsmedizin 18:29–35

    Google Scholar 

  • Matschke J, Tsokos M (2001) Post-traumatic meningitis: histomorphological findings, post-mortem microbiology and forensic implications. Forensic Sci Int 115:199–205

    PubMed  CAS  Google Scholar 

  • Matschke J, Tsokos M (2005) Sudden unexpected death due to undiagnosed glioblastoma: report of three cases and review of the literature. Int J Legal Med 119:280–284

    PubMed  Google Scholar 

  • Matschke J, Tsokos M, Schulz F, Lockemann U (1999) Differential diagnostic aspects of forensically relevant findings in the brain stem. Arch Kriminol 203:108–116

    PubMed  CAS  Google Scholar 

  • Matschke J, Tsokos M, Püschel K (2000) Pilocytic astrocytoma of the brainstem as the cause of death in a 29-year-old man. Rechtsmedizin 10:221–225

    Google Scholar 

  • Matschke J, Stavrou D, Püschel K (2002) Sudden unexpected death due to epidermoid cyst of the brain. Am J Forensic Med Pathol 23:368–370

    PubMed  Google Scholar 

  • Matschke J, Püschel K, Glatzel M (2009) Ocular pathology in shaken baby syndrome and other forms of infantile non-­accidental head injury. Int J Legal Med 123:189–197

    PubMed  Google Scholar 

  • Matschke J, Glatzel M, Püschel K, Andresen H (2010) Fatalities in patients with epilepsy. Rechtsmedizin 20:437–446

    Google Scholar 

  • Matsumoto H, Yamamoto K (1994) A case of sudden death by undiagnosed glioblastoma multiforme. Jpn J Legal Med 47:336–339

    Google Scholar 

  • Maxeiner H, Finck GA (1989) Traumatischer Hirninfarkt bei mehrzeitig verlaufender Dissektion der extrakraniellen Arteria carotis interna. Unfallchirurg 92:321–327

    PubMed  CAS  Google Scholar 

  • McQuillen JB, McQuillen E, Morrow P (1988) Trauma, sport and malignant cerebral edema. Am J Forensic Med Pathol 9:12–15

    PubMed  CAS  Google Scholar 

  • Michiue T, Ishikawa T, Quan L, Li DR, Zhao D, Komatsu A, Zhu BL, Maeda H (2008) Single-stranded DNA as an immunohistochemical marker of neuronal damage in human brain: an analysis of autopsy material with regard to the cause of death. Forensic Sci Int 178:185–191

    PubMed  CAS  Google Scholar 

  • Mirza I, Wolk J, Toth L, Rostenberg P, Kranwinkel R, Sieber SC (2000) Waterhouse-Friderichsen syndrome secondary to Capnocytophaga canimorsus septicaemia and demonstration of bacteremia by peripheral blood smear. Arch Pathol Lab Med 124:859–863

    PubMed  CAS  Google Scholar 

  • Miyazaki T, Kojima T, Chikasue F, Yashiki M, Ito H (1990) Traumatic rupture of intracranial vertebral artery due to hyperextension of the head: reports on three cases. Forensic Sci Int 47:91–98

    PubMed  CAS  Google Scholar 

  • Mork SJ, Morild I, Giertsen JC (1986) Subependymoma and unexpected death. Forensic Sci Int 30:275–280

    PubMed  CAS  Google Scholar 

  • Munger CE, Peiffer RL, Bouldin TW, Kylstra JA, Thompson RL (1993) Ocular and associated neuropathologic observations in suspected whiplash shaken infant syndrome. A retrospective study of 12 cases. Am J Forensic Med Pathol 14:193–200

    PubMed  CAS  Google Scholar 

  • Nakatome M, Matoba R, Ogura Y et al (2002) Detection of cardiomyocyte apoptosis in forensic autopsy cases. Int J Legal Med 116:17–21

    PubMed  CAS  Google Scholar 

  • Nelson J, Frost JL, Schochet SS (1987) Sudden unexpected death in a 5-year-old boy with an unusual primary intracranial neoplasm. Am J Forensic Med Pathol 8:148–152

    PubMed  CAS  Google Scholar 

  • Ng I, Yeo TT, Tang WY, Soong R, Ng PY, Smith DR (2000) Apoptosis occurs after cerebral contusions in humans. Neurosurgery 46:949–956

    PubMed  CAS  Google Scholar 

  • Ng’walali PM, Yonemitsu K, Kibayashi K, Tsunenari S (2002) Neuropathological diagnosis of Alzheimer’s disease in forensic autopsy of elderly persons with fatal accident. Leg Med 4:223–231

    Google Scholar 

  • Nogami M, Takatsu A, Endo N, Ishiyama I (1999a) IgG immunohistochemistry for the assessment of brain injuries in forensic autopsies. Leg Med 1:76–79

    CAS  Google Scholar 

  • Nogami M, Takatsu A, Endo N, Ishiyama I (1999b) Immunohistochemical localization of heat shock protein 70 in the human medulla oblongata in forensic autopsies. Leg Med 1:198–203

    CAS  Google Scholar 

  • Oehmichen M (2001) Brain hypoxia and ischemia. Schmidt-Römhild, Lübeck

    Google Scholar 

  • Oehmichen M, König HG (eds) (1997) Neurotraumatology: biomechanic aspects, cytologic and molecular mechanisms. In: Research in legal medicine, Vol 17. Schmidt-Römhild, Lübeck, pp 239–259

    Google Scholar 

  • Oehmichen M, Meissner C (2006) Cerebral hypoxia and ischemia: the forensic point of view: a review. J Forensic Sci 51:880–887

    Google Scholar 

  • Oehmichen M, Raff G (1980) Timing of cortical contusion. Correlation between histomorphological alterations and post-traumatic interval. Z Rechtsmed 84:79–94

    PubMed  CAS  Google Scholar 

  • Oehmichen M, Eisenmenger W, Raff G, Berghaus G (1986) Brain macrophages in human cortical contusions as an indicator of survival period. Forensic Sci Int 30:281–301

    PubMed  CAS  Google Scholar 

  • Oehmichen M, Meißner C, Schmidt V, Pedal I, König HG, Saternus KS (1998) Axonal injury – a diagnostic tool in forensic neuropathology? A review. Forensic Sci Int 95:67–83

    PubMed  CAS  Google Scholar 

  • Oehmichen M, Meissner C, von Wurmb-Schwank N, Schwank T (2003) Methodological approach to brain hypoxia/ischemia as a fundamental problem in forensic neuropathology. Leg Med 5:190–201

    CAS  Google Scholar 

  • Oehmichen M, Auer RN, König HG (2006) Forensic neuropathology and associated neuropathology. Springer, Berlin, Heidelberg, New York, Tokyo

    Google Scholar 

  • Oehmichen M, Jakob S, Mann S, Saternus KS, Pedal I, Meissner C (2009) Macrophage subsets in mechanical brain injury (MBI) – a contribution to timing of MBI based on immunohistochemical methods: a pilot study. Leg Med 11:118–124

    CAS  Google Scholar 

  • Ogata M, Tsuganezawa O (1999) Neuron-specific enolase as an effective immunohistochemical marker for injured axons after fatal brain injury. Int J Legal Med 113:19–25

    PubMed  CAS  Google Scholar 

  • Ommaya AK, Yarnell P (1969) Subdural hematoma after whiplash injury. Lancet 2:237–239

    PubMed  CAS  Google Scholar 

  • Orihara and Nakasono I (2002) Induction of apolipoprotein E after traumatic brain injury in forensic autopsy cases. Int J Legal Med 116:92–98

    PubMed  Google Scholar 

  • Orihara Y, Tsuda R, Ikematsu K, Nakasono I, Ogata M (2003) Immunohistochemical study on the induction of heme oxygenase-1 by traumatic brain injury. Leg Med 5:S278–S279

    CAS  Google Scholar 

  • Padosch SH, Vogel P, Böttiger BW (2001) Neuronale Apoptose nach zerebraler Ischämie. Anaesthesist 50:905–920

    PubMed  CAS  Google Scholar 

  • Padosch SA, Dettmeyer RB, Schmidt PH, Musshoff F, Madea B (2006) Spinal epidural haematoma after blunt trauma to the neck and hyperflection of the cervical spine. Forensic Sci Int 159:230–234

    PubMed  CAS  Google Scholar 

  • Petito CK, Roberts B (1995) Evidence of apoptotic cell death in HIV encephalitis. Am J Pathol 146:1121–1130

    PubMed  CAS  Google Scholar 

  • Piette MHA, Pieters SEP, de Letter EA (2010) Evaluation of the agonal stress: can immunohistochemical detection of ubiquitin in the locus coeruleus be useful? Int J Leg Med 125(3):333–40, Epub 2010 Apr 16

    Google Scholar 

  • Poon TP, Solis OG (1985) Sudden death due to massive intraventricular hemorrhage into an unsuspected ependymoma. Surg Neurol 24:63–66

    PubMed  CAS  Google Scholar 

  • Pounder DJ (1997) Shaken adult syndrome. Am J Forensic Med Pathol 18:321–324

    PubMed  CAS  Google Scholar 

  • Prahlow JA, Teot LA, Lantz PE, Stanton CA (1995) Sudden death in epilepsy due to an isolated subependymal giant cell astrocytoma of the septum pellucidum. Am J Forensic Med Pathol 16:30–37

    PubMed  CAS  Google Scholar 

  • Preusser M, Kitzwoegener M, Budka H, Brugger S (2007) Bilateral striopallidodentate calcification (Fahr’s syndrome) and multiple system atrophy in a patient with longstanding hypoparathyroidism. Neuropathology 27:453–456

    PubMed  Google Scholar 

  • Quan L, Zhu BL, Ishida K, Oritani S, Taniguchi M, Fujita MQ, Maeda H (2001) Intranuclear ubiquitin immunoreactivity of the pigmented neurons of the substantia nigra in fatal acute mechanical asphyxiation and drowning. Int J Legal Med 115:6–11

    PubMed  CAS  Google Scholar 

  • Quan L, Ishikawa T, Michique T et al (2005a) Ubiquitin-immunoreactive structures in the midbrain of methamphetamine abusers. Leg Med 7:144–150

    CAS  Google Scholar 

  • Quan L, Ishikawa T, Michiue T, Li DR, Zhao D, Zhu BL, Maeda H (2005b) Quantitative analysis of ubiquitin-immunoreactivity in the midbrain periaqueductal gray matter with regard to the causes of death in forensic autopsy. Leg Med 7:151–156

    CAS  Google Scholar 

  • Quan L, Ishikawa T, Michiue T, Li DR, Zhao D, Zhu BL, Maeda H (2005c) Ubiquitin immunoreactivity in the midbrain as a marker of stress to motor nervous systems in fatal injury. Leg Med 7:157–163

    CAS  Google Scholar 

  • Racette S, Sauvageau A (2007) Brain arteriovenous malformation and its implication in forensic pathology. J Forensic Sci 52:189–191

    PubMed  Google Scholar 

  • Raul JS, Roth S, Ludes B, Willinger R (2008) Influence of the benign enlargement of the subarachnoid space on the bridging veins strain during a shaking event: a finite element study. Int J Legal Med 12:337–340

    Google Scholar 

  • Reichard RR, White CL 3rd, Hladik CL, Dolinak D (2003) Beta-amyloid precursor protein staining in nonhomicidal pediatric medicolegal autopsies. J Neuropathol Exp Neurol 62:237–247

    PubMed  Google Scholar 

  • Riffenburgh RS, Sathyavagiswaran L (1991) The eyes of child abuse victims: autopsy findings. J Forensic Sci 36:741–747

    PubMed  CAS  Google Scholar 

  • Riordan FAI, Marzouk O, Thomson APJ, Sills JA, Hart CA (1995) The changing presentations of meningococcal disease. Eur J Pediatr 154:472–474

    PubMed  CAS  Google Scholar 

  • Riße M, Weiler G (1984) Heroinsucht als seltene Ursache einer symmetrischen Pallidumnekrose. Z Rechtsmed 93:227–235

    PubMed  Google Scholar 

  • Roth S, Raul JS, Ludes B, Willinger R (2007) Finite element analysis of impact and shaking inflicted to a child. Int J Legal Med 121:223–228

    PubMed  Google Scholar 

  • Ryan CA, Wenman W, Hennigsen C, Tse S (1993) Fatal childhood pneumococcal Waterhouse-Friderichsen syndrome. Pediatr Infect Dis J 12:250–251

    PubMed  CAS  Google Scholar 

  • Saito K, Takda A, Kuroda N, Hara M, Arai M, Ro A (2009) Traumatic dissection of extracranial vertebral artery with massive subtentorial cerebral infarction: report of an autopsy case. Leg Med 11:S520–S522

    Google Scholar 

  • Sakai K, Takatsu A, Shigeta A, Abe S, Ikegami M, Takagi K (2007) Sudden death due to undiagnosed acute promyelocytic leukaemia: a case report. Int J Legal Med 121:311–314

    PubMed  Google Scholar 

  • Sato M, Hashimoto H, Kosaka F (1990) Histological changes of neuronal damage in vegetative dogs induced by 18 minutes of complete global brain ischemia: two phase damage of Purkinje cells and hippocampal CA1 pyramidal cells. Acta Neuropathol 80:527–534

    PubMed  CAS  Google Scholar 

  • Schwarz KO, Perper JA, Rozin I (1987) Sudden, unexpected death due to fourth ventricular subependymoma. Am J Forensic Med Pathol 8:153–157

    PubMed  CAS  Google Scholar 

  • Sezen F (1971) Retinal haemorrhages in newborn infants. Br J Ophthalmol 55:248–253

    PubMed  CAS  Google Scholar 

  • Sheriff FE, Bridges LR, Sivaloganatham S (1994) Early detection of axonal injury after human head trauma using immunocytochemistry for ß-amyloid protein. Acta Neuropathol 87:55–62

    Google Scholar 

  • Sherriff FE, Bridges LR, Sivaloganathan S (1994) Early detection of axonal injury after human head trauma using immunocytochemistry for beta-amyloid precursor protein. Acta Neuropathol 87:55–62

    PubMed  CAS  Google Scholar 

  • Simonsen J (1963) Traumatic subarachnoid hemorrhage in alcohol intoxication. J Forensic Sci 8:97–116

    PubMed  CAS  Google Scholar 

  • Simonsen J (1984) Fatal subarachnoid haemorrhages in relation to minor injuries in Denmark from 1967 to 1981. Forensic Sci Int 24:57–63

    PubMed  CAS  Google Scholar 

  • Sperhake JP, Tsokos M (2004) Pathological features of Waterhouse-Friderichsen syndrome in infancy and childhood. In: Toskos M (ed) Forensic pathology reviews, vol 1. Humana Press Inc, Totowa, pp 219–231

    Google Scholar 

  • Sperling MR (2001) Sudden unexplained death in epilepsy. Epilepsy Curr 1:21–23

    PubMed  Google Scholar 

  • Squier W, Mack J (2009) The neuropathology of infant subdural haemorrhage. Forensic Sci Int 187:6–13

    PubMed  Google Scholar 

  • Strassmann G (1949) Formation of hemosiderin after traumatic and spontaneous cerebral hemorrhages. Arch Pathol 47:205–210

    CAS  Google Scholar 

  • Strassmann G, Helpern M (1968) Tödliche Hirnverletzungen im Boxkampf. Dtsch Zschr Gerichtl Med 63:70–83

    CAS  Google Scholar 

  • Suárez-Peñanranda JM, Rodríguez-Calvo MS, Ortiz-REy JA et al (2002) Demonstration of apoptosis in human skin injuries as an indicator of vital reaction. Int J Legal Med 116:109–112

    Google Scholar 

  • Suzuki A, Shiraki K (2001) Tumor cell “dead or alive”: caspase and surviving regulate cell death, cell cycle and cell survival. Histol Histopathol 16:583–593

    PubMed  CAS  Google Scholar 

  • Tao L, Chen X, Qin Z, Bian S (2006) Could NF-kB and caspase-3 be markers for estimation of post-interval of human traumatic brain injury? Forensic Sci Int 162:174–177

    PubMed  CAS  Google Scholar 

  • Tardieu A (1860) Étude medico-légale sur les sévices et mauvais traitements exercés sur des enfants. Annales d’Hygiène Publique et de Medicine Légale 13:361–398

    Google Scholar 

  • Thornstedt H, Voigt GE (1960) Tödliche, basale Subarachnoi­dalblutung nach Trauma. Dtsch Zschr Gerichtl Med 50:254–277

    CAS  Google Scholar 

  • Tsokos M (2003) Fatal Waterhouse-Friderichsen syndrome due to Ewingella americana infection. Am J Forensic Med Pathol 24:41–44

    PubMed  Google Scholar 

  • Tsokos M, Püschel K (2001) Postmortem bacteriology in forensic pathology: diagnostic value and interpretation. Leg Med 3:15–22

    CAS  Google Scholar 

  • Tyagi AK, Willshaw HE, Ainsworth JR (1997) Unilateral retinal haemorrhages in non-accidental injury. Lancet 349:1224

    PubMed  CAS  Google Scholar 

  • Tyagi AK, Scotcher S, Kozeis N, Willshaw HE (1998) Can convulsions alone cause retinal haemorrhages in infants? Br J Ophthalmol 82:659–660

    PubMed  CAS  Google Scholar 

  • Uemura K, Harada K, Sadmitsu D, Tsuruta R, Takahashi M, Aki T, Yasuhara M, Maekawa T, Yoshida K (2001) Apoptotic and necrotic brain lesions in a fatal case of carbon monoxide poisoning. Forensic Sci Int 116:213–219

    PubMed  CAS  Google Scholar 

  • Unger PD, Song S, Taff ML, Schwarz IS (1984) Sudden death in a patient with von Recklinghausen’s neurofibromatosis. Am J Forensic Med Pathol 5:175–179

    PubMed  CAS  Google Scholar 

  • Unkrig S, Gulotta F, Madea B (2010) Morbus Fahr – considerations on a case of sudden death. Forensic Sci Int 204:e12–e15

    PubMed  Google Scholar 

  • Unterharnscheidt F (1970) About boxing: review of historical and medical aspects. Tex Rep Biol Med 28:421–495

    PubMed  CAS  Google Scholar 

  • Unterharnscheidt F (1975) Injuries due to boxing and other sports. In: Winken PJ, Bruyn GW (eds) Handbook of clinical neurology, vol 23., pp 527–593

    Google Scholar 

  • Varchmin-Schultheiß K, Holtz J, Horn M (1990) Waterhouse-Friderichsen-Syndrom im Erwachsenenalter. Beitr Gerichtl Med 48:229–231

    PubMed  Google Scholar 

  • Viitanen M, Johansson K, Bogdanovic N et al (1998) Alzheimer changes are common in aged drivers killed in single car crashes and at intersections. Forensic Sci Int 96:115–127

    PubMed  CAS  Google Scholar 

  • Vowles GH, Cl S, Cameron JM (1987) Diffuse axonal injury in early infancy. J Clin Pathol 40:185–189

    PubMed  CAS  Google Scholar 

  • Waterhouse R (1911) A case of suprarenal apoplexy. Lancet 1:577

    Google Scholar 

  • Weedn VW, Mansour AM, Nichols MM (1990) Retinal hemorrhage in an infant after cardiopulmonary resuscitation. Am J Forensic Med Pathol 11:79–82

    PubMed  CAS  Google Scholar 

  • Weiler G, Reinhardt V, Nau HE, Gerhard L (1980) Contribution to intracranial “traumatic aneurysm”. Z Rechtsmed 85:225–233

    PubMed  CAS  Google Scholar 

  • Wick R, Byard RW (2006) Mechanisms of unexpected and/or sudden death in Lafora disease. Forensic Sci Int 163:144–147

    PubMed  Google Scholar 

  • Wojahn H (1970) Klärung einer Abtreibung mit zentraler Luftembolie nach 4 Jahren. Beitr Gerichtl Med 27:97–100

    PubMed  CAS  Google Scholar 

  • Zappi E, Zappi M, Breithaupt M, Zugibe FT (1993) Cerebral intraventricular lipoma and sudden death. J Forensic Sci 38:489–492

    PubMed  CAS  Google Scholar 

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Dettmeyer, R.B. (2011). Forensic Neuropathology. In: Forensic Histopathology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-20659-7_20

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