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Fluoride Agents and Dental Caries

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Pediatric Restorative Dentistry

Abstract

Among the strategies available for caries control, fluoride therapy remains the most widespread used around the World. The anticaries properties of fluoride, as well as the mechanisms of action of the fluoridated salts used in vehicles for community, professional, and self-application, have been well documented over several decades. This chapter will focus on methods for home and professional use of fluoride, highlighting the mechanisms of action involved, mode of application, safety measures, as well as their clinical efficacy considering the best scientific evidence available.

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References

  1. Sampaio FC, Levy SM. Systemic fluoride. Monogr Oral Sci. 2011;22:133–45.

    Article  Google Scholar 

  2. FDI (World Dental Federation). The challenge of oral disease—a call for global action. The Oral Health Atlas, 2nd ed. Geneva; 2015.

    Google Scholar 

  3. Buzalaf MA, Pessan JP, Honório HM, ten Cate JM. Mechanisms of action of fluoride for caries control. Monogr Oral Sci. 2011;22:97–114.

    Article  Google Scholar 

  4. Buzalaf MAR. Review of fluoride intake and appropriateness of current guidelines. Adv Dent Res. 2018;29(2):157–66.

    Article  Google Scholar 

  5. Bibby BG, Wilkins E, Witol E. A preliminary study of the effects of fluoride lozenges and pills on dental caries. Oral Surg Oral Med Oral Pathol. 1955;8(2):213–6.

    Article  Google Scholar 

  6. Ogaard B, Rölla G, Dijkman T, Ruben J, Arends J. Effect of fluoride mouthrinsing on caries lesion development in shark enamel: an in situ caries model study. Scand J Dent Res. 1991;99(5):372–7.

    PubMed  Google Scholar 

  7. Ogaard B, Rölla G, Ruben J, Dijkman T, Arends J. Microradiographic study of demineralization of shark enamel in a human caries model. Scand J Dent Res. 1988;96(3):209–11.

    PubMed  Google Scholar 

  8. Arends J, Christoffersen J. Nature and role of loosely bound fluoride in dental caries. J Dent Res. 1990;69(Spec Iss):601–5. discussion 634–6.

    Article  Google Scholar 

  9. ten Cate JM. Current concepts on the theories of the mechanism of action of fluoride. Acta Odontol Scand. 1999;57(6):325–9.

    Article  Google Scholar 

  10. Saxegaard E, Rolla G. Fluoride acquisition on and in human enamel during topical application in vitro. Scand J Dent Res. 1988;96(6):523–35.

    PubMed  Google Scholar 

  11. Featherstone JD. Prevention and reversal of dental caries: role of low level fluoride. Community Dent Oral Epidemiol. 1999;27:31–40.

    Article  Google Scholar 

  12. Bowden GHW. Effects of fluoride on the microbial ecology of dental plaque. J Dent Res. 1990;69(Spec Iss):653–9.

    Article  Google Scholar 

  13. Elwood RP, Fejerskov O, Cury JA, Clarkson B. Fluoride in caries control. In: Fejerskov O, Kidd EAM, editors. Dental caries: the disease and its clinical management. 2nd ed. Oxford: Blackwell & Munksgaard; 2008. p. 287–323.

    Google Scholar 

  14. Pessan JP, Toumba KJ, Buzalaf MA. Topical use of fluorides for caries control. Monogr Oral Sci. 2011;22:115–32.

    Article  Google Scholar 

  15. Chong LY, Clarkson JE, Dobbyn-Ross L, Bhakta S. Slow-release fluoride devices for the control of dental decay. Cochrane Database Syst Rev. 2018;3:CD005101.

    PubMed  Google Scholar 

  16. Marinho VC, Worthington HV, Walsh T, Chong LY. Fluoride gels for preventing dental caries in children and adolescents. Cochrane Database Syst Rev. 2015;15(6):CD002280.

    Google Scholar 

  17. Marinho VC, Chong LY, Worthington HV, Walsh T. Fluoride mouthrinses for preventing dental caries in children and adolescents. Cochrane Database Syst Rev. 2016;7:CD002284.

    PubMed  Google Scholar 

  18. Marinho VC, Worthington HV, Walsh T, Clarkson JE. Fluoride varnishes for preventing dental caries in children and adolescents. Cochrane Database Syst Rev. 2013;11(7):CD002279.

    Google Scholar 

  19. Marinho VC, Higgins JP, Sheiham A, Logan S. Fluoride toothpastes for preventing dental caries in children and adolescents. Cochrane Database Syst Rev. 2003;1:CD002278.

    Google Scholar 

  20. Delbem AC, Cury JA. Effect of application time of APF and NaF gels on microhardness and fluoride uptake of in vitro enamel caries. Am J Dent. 2002;15(3):169–72.

    PubMed  Google Scholar 

  21. Delbem AC, Carvalho LP, Morihisa RK, Cury JA. Effect of rinsing with water immediately after APF gel application on enamel demineralization in situ. Caries Res. 2005;39(3):258–60.

    Article  Google Scholar 

  22. Delbem AC, Danelon M, Sassaki KT, Vieira AE, Takeshita EM, Brighenti FL, Rodrigues E. Effect of rinsing with water immediately after neutral gel and foam fluoride topical application on enamel remineralization: an in situ study. Arch Oral Biol. 2010;55(11):913–8.

    Article  Google Scholar 

  23. Bijella MF, Bijella VT, Lopes ES, Bastos JR. Comparison of dental prophylaxis and toothbrushing prior to topical APF applications. Community Dent Oral Epidemiol. 1985;13(4):208–11.

    Article  Google Scholar 

  24. Weyant RJ, Tracy SL, Anselmo TT, Beltrán-Aguilar ED, Donly KJ, Frese WA, Dental Association Council on Scientific Affairs Expert Panel on Topical Fluoride Caries Preventive Agents, et al. American Topical fluoride for caries prevention: executive summary of the updated clinical recommendations and supporting systematic review. J Am Dent Assoc. 2013;144(11):1279–91.

    Article  Google Scholar 

  25. Jiang H, Bian Z, Tai BJ, Du MQ, Peng B. The effect of a bi-annual professional application of APF foam on dental caries increment in primary teeth: 24-month clinical trial. J Dent Res. 2005;84(3):265–8.

    Article  Google Scholar 

  26. Jiang H, Tai B, Du M, Peng B. Effect of professional application of APF foam on caries reduction in permanent first molars in 6-7-year-old children: 24-month clinical trial. J Dent. 2005;33(6):469–73.

    Article  Google Scholar 

  27. Jiang H, Hua F, Yao L, Tai B, Du M. Effect of 1.23% acidulated phosphate fluoride foam on white spot lesions in orthodontic patients: a randomized trial. Pediatr Dent. 2013;35(3):275–8.

    PubMed  Google Scholar 

  28. Twetman S, Keller MK. Fluoride rinses, gels and foams: an update of controlled clinical trials. Caries Res. 2016;50(Suppl 1):38–44.

    Article  Google Scholar 

  29. Pessan JP, Pin ML, Martinhon CC, de Silva SM, Granjeiro JM, Buzalaf MA. Analysis of fingernails and urine as biomarkers of fluoride exposure from dentifrice and varnish in 4- to 7-year-old children. Caries Res. 2005;39(5):363–70.

    Article  Google Scholar 

  30. American Dental Association Council on Scientific Affairs. Professionally applied topical fluoride: evidence-based clinical recommendations. J Am Dent Assoc. 2006;137(8):1151–9.

    Article  Google Scholar 

  31. Pessan JP, Sicca CM, de Souza TS, da Silva SM, Whitford GM, Buzalaf MA. Fluoride concentrations in dental plaque and saliva after the use of a fluoride dentifrice preceded by a calcium lactate rinse. Eur J Oral Sci. 2006;114(6):489–93.

    Article  Google Scholar 

  32. Walsh T, Worthington HV, Glenny AM, Appelbe P, Marinho VC, Shi X. Fluoride toothpastes of different concentrations for preventing dental caries in children and adolescents. Cochrane Database Syst Rev. 2010;20(1):CD007868.

    Google Scholar 

  33. Lima TJ, Ribeiro CC, Tenuta LM, Cury JA. Low-fluoride dentifrice and caries lesion control in children with different caries experience: a randomized clinical trial. Caries Res. 2008;42(1):46–50.

    Article  Google Scholar 

  34. Wong MC, Glenny AM, Tsang BW, Lo EC, Worthington HV, Marinho VC. Topical fluoride as a cause of dental fluorosis in children. Cochrane Database Syst Rev. 2010;20(1):CD007693.

    Google Scholar 

  35. Zero DT, Creeth JE, Bosma ML, Butler A, Guibert RG, Karwal R, Lynch RJ, Martinez-Mier EA, González-Cabezas C, Kelly SA. The effect of brushing time and dentifrice quantity on fluoride delivery in vivo and enamel surface microhardness in situ. Caries Res. 2010;44(2):90–100.

    Article  Google Scholar 

  36. Creeth J, Zero D, Mau M, Bosma ML, Butler A. The effect of dentifrice quantity and toothbrushing behaviour on oral delivery and retention of fluoride in vivo. Int Dent J. 2013;63(Suppl 2):14–24.

    Article  Google Scholar 

  37. Hall KB, Delbem AC, Nagata ME, Hosida TY, de Moraes FR, Danelon M, Cunha RF, Pessan JP. Influence of the amount of dentifrice and fluoride concentrations on salivary fluoride levels in children. Pediatr Dent. 2016;38(5):379–84.

    PubMed  Google Scholar 

  38. Paiva MF, Delbem ACB, Danelon M, Nagata ME, Moraes FRN, Coclete GEG, Cunha RF, Buzalaf MAR, Pessan JP. Fluoride concentration and amount of dentifrice influence enamel demineralization in situ. J Dent. 2017;66:18–22.

    Article  Google Scholar 

  39. Iheozor-Ejiofor Z, Worthington HV, Walsh T, O’Malley L, Clarkson JE, Macey R, Alam R, Tugwell P, Welch V, Glenny AM. Water fluoridation for the prevention of dental caries. Cochrane Database Syst Rev. 2015;6:CD010856.

    Google Scholar 

  40. Marthaler TM. Salt fluoridation and oral health. Acta Med Acad. 2013;42(2):140–55.

    Article  Google Scholar 

  41. Yeung CA, Chong LY, Glenny AM. Fluoridated milk for preventing dental caries. Cochrane Database Syst Rev. 2015;3(9):CD003876.

    Google Scholar 

  42. Marinho VC, Higgins JP, Sheiham A, Logan S. Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for preventing dental caries in children and adolescents. Cochrane Database Syst Rev. 2004;1:CD002781.

    Google Scholar 

  43. Marinho VC, Higgins JP, Sheiham A, Logan S. One topical fluoride (toothpastes, or mouthrinses, or gels, or varnishes) versus another for preventing dental caries in children and adolescents. Cochrane Database Syst Rev. 2004;1:CD002780.

    Google Scholar 

  44. Sheiham A, James WP. Diet and dental caries: the pivotal role of free sugars reemphasized. J Dent Res. 2015;94(10):1341–7.

    Article  Google Scholar 

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Correspondence to Alberto C. B. Delbem .

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Delbem, A.C.B., Pessan, J.P. (2019). Fluoride Agents and Dental Caries. In: Coelho Leal, S., Takeshita, E. (eds) Pediatric Restorative Dentistry. Springer, Cham. https://doi.org/10.1007/978-3-319-93426-6_5

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  • DOI: https://doi.org/10.1007/978-3-319-93426-6_5

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