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A Software App for Radiotherapy with In-situ Dose-painting using high Z nanoparticles

  • Conference paper
World Congress on Medical Physics and Biomedical Engineering, June 7-12, 2015, Toronto, Canada

Part of the book series: IFMBE Proceedings ((IFMBE,volume 51))

Abstract

The purpose of this work is to develop a user friendly and free-to-download application software that can be employed for modeling Radiotherapy with In-situ Dosepainting (RAID) using high-Z nanoparticles (HZNPs). The RAID APP is software program written in Matlab (Mathworks, Natick, MA, USA) based on deterministic code developed to simulate the space-time intra-tumor HZNPs biodistribution within the tumor, and the corresponding dose enhancement in response to low dose rate (LDR) brachytherapy of I-125, Pd-102, Cs-131 and kilovoltage x-rays such as 50 keV and 100 keV. Through the graphical user interface (GUI) of the RAID APP, the user will be directed to different features to compute various parameters related to the dose enhancement and the biodistribution of NPs within high risk tumor sub-volumes. The software was developed as a tool for research purposes with potential for subsequent development to guide dose-painting treatment planning using radiosensitizers such as gold (Au) and platinum (Pt).

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Authors and Affiliations

  1. Department of Physics and Applied Physics, Medical Physics Program, University of Massachusetts, Lowell, MA, USA

    M Jermoumi, A Yucel, Y Hao, G Cifter, E Sajo & W Ngwa

  2. Department of Radiation Oncology, Brigham and Women’s Hospital, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA

    M Jermoumi, G Cifter & W Ngwa

Authors
  1. M Jermoumi
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  2. A Yucel
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  3. Y Hao
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  4. G Cifter
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  5. E Sajo
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  6. W Ngwa
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Editors and Affiliations

  1. Techna Institute, University Health Network, Toronto, Ontario, Canada

    David A. Jaffray

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© 2015 Springer International Publishing Switzerland

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Jermoumi, M., Yucel, A., Hao, Y., Cifter, G., Sajo, E., Ngwa, W. (2015). A Software App for Radiotherapy with In-situ Dose-painting using high Z nanoparticles. In: Jaffray, D. (eds) World Congress on Medical Physics and Biomedical Engineering, June 7-12, 2015, Toronto, Canada. IFMBE Proceedings, vol 51. Springer, Cham. https://doi.org/10.1007/978-3-319-19387-8_151

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  • DOI: https://doi.org/10.1007/978-3-319-19387-8_151

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-19386-1

  • Online ISBN: 978-3-319-19387-8

  • eBook Packages: EngineeringEngineering (R0)

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