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Adipokines and Metabolism

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Metabolic Syndrome

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Abstract

Adipose tissue is the main site of energy storage in the form of triglycerides. Mature adipocytes also produce enzymes, growth factors, cytokines, chemokines, and hormones (adipokines) implicated in the modulation of feeding, energy homeostasis, lipid and glucose metabolism, inflammation, coagulation, and cardiovascular system. Obesity alters the expression, circulating levels, and signaling mechanisms of adipose-secreted factors, and these changes have been linked to the development of insulin resistance, type 2 diabetes, dyslipidemia, atherosclerosis, cancer, and other diseases.

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Acknowledgments

This work was supported by grant P01-DK-049210 from the National Institutes of Health, USA.

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  1. Division of Endocrinology, Diabetes and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA

    Rexford S. Ahima

  2. Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania, Philadelphia, PA, USA

    Rexford S. Ahima

  3. Department of Internal Medicine, Soonchunhyang University College of Medicine, Seoul, South Korea

    Hyeong-Kyu Park

  4. Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, and the Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Laura M. Scolaro

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    Rexford S. Ahima

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    Rexford S. Ahima

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Ahima, R.S., Scolaro, L.M., Park, HK. (2016). Adipokines and Metabolism. In: Ahima, R.S. (eds) Metabolic Syndrome. Springer, Cham. https://doi.org/10.1007/978-3-319-11251-0_24

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-11250-3

  • Online ISBN: 978-3-319-11251-0

  • eBook Packages: MedicineReference Module Medicine

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